公开(公告)号：US20070140860A1

公开(公告)日：2007-06-21

申请号：US11312060

申请日：2005-12-20

Applicant: Stephen Mitchell

Inventor： Stephen Mitchell

IPC: F01D5/14

CPC classification number: F01D25/02 ,  F01D5/00 ,  F02C7/047 ,  Y02T50/672 ,  Y02T50/673

Abstract: A method for manufacturing a turbine engine component includes forming a component to include a first side and an opposite second side, positioning at least one capillary adjacent to an external surface of at least one of the first and second sides, and securing the at least one capillary to the component with at least one composite layer.

Abstract translation: 一种用于制造涡轮发动机部件的方法包括形成包括第一侧和相对的第二侧的部件，将邻近第一和第二侧中的至少一个的外表面定位至少一个毛细管，并且将至少一个 毛细管与具有至少一个复合层的部件。

公开(公告)号：US20060275304A1

公开(公告)日：2006-12-07

申请号：US11200973

申请日：2005-08-09

Applicant: Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: A61K39/395 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C07K14/82 ,  C07K16/46

CPC classification number: C07K16/40 ,  A61K38/00 ,  C12N9/6421

Abstract: Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell surface serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provides are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. Several monoclonal antibodies specifically reactive with 20P1F12/TMPRSS2 are also described herein.

Abstract translation: 描述了源自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞表面丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 组合物中提供的是与20P1F12 / TMPRSS2蛋白及其多肽片段结合的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本文还描述了与20P1F12 / TMPRSS2特异性反应的几种单克隆抗体。

公开(公告)号：US20050202454A1

公开(公告)日：2005-09-15

申请号：US10858887

申请日：2004-06-01

Applicant: Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: G01N33/574 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12P21/08 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30

CPC classification number: C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.

Abstract translation: 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达，也是在前列腺癌中，因此这个家族的成员被称为“前列腺的蛇纹石逆转膜抗原”。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STRAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20070261310A1

公开(公告)日：2007-11-15

申请号：US11657713

申请日：2007-01-25

Applicant: Alex Porat ,  Salvatore Vitale ,  Stephen Mitchell ,  Eduard Vasilescu ,  Peter Oxley ,  Gordon Paton ,  Jason Niskanen ,  Andrew Daniels ,  Dragan Mrkovic

Inventor： Alex Porat ,  Salvatore Vitale ,  Stephen Mitchell ,  Eduard Vasilescu ,  Peter Oxley ,  Gordon Paton ,  Jason Niskanen ,  Andrew Daniels ,  Dragan Mrkovic

IPC: E05F15/12

CPC classification number: E05F1/1091 ,  E05F15/622 ,  E05Y2201/11 ,  E05Y2600/40 ,  E05Y2800/29 ,  E05Y2900/548

Abstract: An actuating device is provided for moving a closure panel between an open position spaced apart from a vehicle body and a closed position abutting the vehicle body to close an access opening thereof. The actuating device includes a telescopic arm having a first member coupled to one of the closure panel and the vehicle body and a second member coupled to the other of the closure panel and the vehicle body. The first and second members are slidable relative to one another to move the actuating device between a retracted position corresponding with the closed position and an extended position corresponding with the open position. A screw is rotatable relative to the first member. The screw includes a cavity formed therewithin. A nut is secured to the second member and threadingly engages the screw such that rotation of the screw moves the second member towards and away from the first member to move the actuating device between the respective retracted and extended positions. A gas spring is at least partially disposed within the cavity of the screw for urging the actuating device into the extended position to move the closure panel into the open position.

Abstract translation: 提供一种致动装置，用于在与车身间隔开的打开位置和邻近车体的关闭位置之间移动闭合面板以关闭其进入开口。 所述致动装置包括伸缩臂，所述伸缩臂具有联接到所述闭合面板和所述车体中的一个的第一构件和联接到所述闭合面板和所述车体中的另一个的第二构件。 第一和第二构件可相对于彼此滑动以使致动装置在对应于关闭位置的缩回位置与对应于打开位置的延伸位置之间移动。 螺杆可相对于第一构件旋转。 螺杆包括在其中形成的空腔。 螺母固定到第二构件并螺纹地接合螺钉，使得螺钉的旋转使第二构件朝向和远离第一构件移动，以使致动装置在相应的缩回位置和延伸位置之间移动。 气体弹簧至少部分地设置在螺钉的空腔内，用于将致动装置推进伸出位置，以将封闭板移动到打开位置。

公开(公告)号：US20060147951A1

公开(公告)日：2006-07-06

申请号：US11225661

申请日：2005-09-12

Applicant: Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC classification number: C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and Intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed In certain other human cancers.

Abstract translation: 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达，以及在前列腺癌中，因此该家族的成员被称为前列腺的“STRAP”蛇纹石TRANmembrane抗原。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STRAP-1在某些其他人类癌症中高度过度表达。

公开(公告)号：US20050155983A1

公开(公告)日：2005-07-21

申请号：US10504614

申请日：2003-02-14

Applicant: David Robinson ,  Stephen Mitchell

Inventor： David Robinson ,  Stephen Mitchell

IPC: B67D3/00 ,  B67D5/60

CPC classification number: B67D3/0029

Abstract: Dispensing apparatus is provided which includes a reservoir for containing a liquid therein which is supported by support means in use. The reservoir has an opening into which valve means are located. The valve means are movable between an open condition, wherein a user can dispense the liquid from the reservoir, and a closed condition, wherein the opening is closed. The valve means are a spaced distance from and separate to the support means. In addition, the reservoir is provided with means to allow releasable engagement with the support means, thereby allowing the reservoir to be located with and removed from the support means as and when required.

Abstract translation: 提供分配装置，其包括用于容纳其中的液体的储存器，其在使用中由支撑装置支撑。 储存器具有阀装置所在的开口。 阀装置可以在打开状态之间移动，在打开状态下，使用者可以从储存器中分配液体和关闭状态，其中开口被关闭。 阀装置与支撑装置隔开距离并分离。 此外，储存器设置有允许与支撑装置可释放地接合的装置，从而允许储存器在需要时与支撑装置一起定位并从支撑装置移除。

公开(公告)号：US09205329B2

公开(公告)日：2015-12-08

申请号：US11828019

申请日：2007-07-25

Applicant: Stephen Mitchell

Inventor： Susan McBride ,  Stephen Mitchell

IPC: A63F13/00 ,  A63F13/30

CPC classification number: A63F13/31 ,  A63F9/24 ,  A63F13/12 ,  A63F13/235 ,  A63F13/335 ,  A63F13/35 ,  A63F13/825 ,  A63F13/92 ,  A63F2009/2457 ,  A63F2300/204 ,  A63F2300/405 ,  A63F2300/407 ,  A63F2300/5533 ,  A63F2300/5553

Abstract: An electronic game for playing on a portable handheld game unit and on-line includes a dynamic animated virtual character that can be customized and updated both visually and functionally through game play and that can translate from a two dimensional visual presentation on a game unit to a higher order visual presentation in an interactive multi-player virtual world on-line and back while retaining any customization or upgrades is provided. Different versions of the electronic game produce different virtual characters that can interact on-line or through wireless linkage between game units.

Abstract translation: 一种用于在便携式手持游戏单元上播放的电子游戏，包括动态的动画虚拟角色，其可以在视觉上和功能上通过游戏进行定制和更新，并且可以从游戏单元上的二维视觉呈现转换为 提供了在互动式多玩家虚拟世界中的在线和背面的高阶视觉呈现，同时保留任何定制或升级。 电子游戏的不同版本产生不同的虚拟角色，可以在线或通过游戏单元之间的无线连接互动。

公开(公告)号：US20060201135A1

公开(公告)日：2006-09-14

申请号：US11274972

申请日：2005-11-16

Applicant: Ming Xie ,  Stephen Mitchell ,  Donald LaChapelle ,  Michael Braley ,  Gary Roberts ,  Dale Hopkins

Inventor： Ming Xie ,  Stephen Mitchell ,  Donald LaChapelle ,  Michael Braley ,  Gary Roberts ,  Dale Hopkins

IPC: F02K3/04

CPC classification number: F01D21/045 ,  D04C1/02 ,  D10B2505/02 ,  F01D25/24 ,  F05D2300/44 ,  F05D2300/603 ,  F05D2300/702 ,  Y02T50/672

Abstract: A composite fan casing for a gas turbine engine includes, in an exemplary embodiment, a core having a plurality of core layers of reinforcing fiber bonded together with a thermosetting polymeric resin. Each core layer includes a plurality of braided reinforcing fiber tows. The braids of reinforcing fiber tows are aligned in a circumferential direction with each fiber tow including a plurality of reinforcing fibers. The core also includes at least one additional fiber tow braided into at least one predetermined axial location to form at least one concentrated stiffening ring.

Abstract translation: 在示例性实施例中，用于燃气涡轮发动机的复合风扇壳体包括具有多个与热固性聚合物树脂结合在一起的增强纤维芯层的芯体。 每个芯层包括多个编织的增强纤维束。 增强纤维丝束的编织物在圆周方向上排列，每条纤维束包括多根增强纤维。 芯还包括至少一个额外的纤维束，其编织成至少一个预定的轴向位置以形成至少一个集中的加强环。

公开(公告)号：US20060082188A1

公开(公告)日：2006-04-20

申请号：US11199470

申请日：2005-08-08

Applicant: Stephen Mitchell

Inventor： Stephen Mitchell

IPC: B60J5/10

CPC classification number: E05F1/1008 ,  E05F1/1041 ,  E05F15/622 ,  E05Y2201/216 ,  E05Y2201/246 ,  E05Y2201/434 ,  E05Y2201/462 ,  E05Y2201/72 ,  E05Y2800/242 ,  E05Y2900/546

Abstract: An electromechanical strut using an inline motor coupled to an inline planetary gear that are both mounted in the lower housing. The motor-gear assembly drives a worm gear and nut screw in the upper housing, extending or retracting an extensible shaft. Additionally, a power spring mounted coaxially around the worm gear provides a mechanical counterbalance to the weight of a lift gate on the shaft. As the shaft extends, the power spring uncoils, assisting the motor-gear assembly in raising the lift gate. Retracting the shaft recoils the spring, storing potential energy. Thus, a lower torque motor-gear assembly can be used, reducing the diameter of the lower housing. Preferably, the power spring can also drive the power screw to extend the strut even when the motor-gear assembly is not engaged.

Abstract translation: 使用连接在行星齿轮上的内联马达的机电支柱，两者均安装在下壳体中。 电机齿轮组件驱动上壳体中的蜗轮和螺母螺钉，延伸或缩回可延伸轴。 另外，同轴地安装在蜗轮上的动力弹簧为轴上的提升门的重量提供了机械平衡。 当轴延伸时，动力弹簧展开，辅助马达齿轮组件升高升降门。 回缩轴回弹弹簧，储存潜在的能量。 因此，可以使用较低扭矩的电机 - 齿轮组件，减小下部壳体的直径。 优选地，即使当电动机 - 齿轮组件未接合时，动力弹簧也可以驱​​动动力螺钉来延伸支柱。

公开(公告)号：US20050064445A1

公开(公告)日：2005-03-24

申请号：US10750262

申请日：2003-12-31

Applicant: Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

Inventor： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

IPC: G01N33/574 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12P21/08 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that It folds In a “serpentine” manner Into three extracellular and two Intracellular loops. STRAP-1 protein expression Is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.

Abstract translation: 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达，也是在前列腺癌中，因此这个家族的成员被称为“前列腺的蛇纹石逆转膜抗原”。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个细胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STRAP-1在某些其他人类癌症中高度过度表达。