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![Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases](/abs-image/US/2011/12/01/US20110294776A1/abs.jpg.150x150.jpg)
1.发明申请Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases 失效吡咯并[2,1-F] [1,2,4]三嗪-4-基胺IGF-1R激酶抑制剂治疗癌症和其他过度增生性疾病公开(公告)号：US20110294776A1
公开(公告)日：2011-12-01
申请号：US12084411
申请日：2006-11-02
申请人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号： A61K31/53 , C07D498/04 , A61P35/00 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译： 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
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![Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases](/abs-image/US/2013/04/30/US08431695B2/abs.jpg.150x150.jpg)
2.发明授权Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号：US08431695B2
公开(公告)日：2013-04-30
申请号：US12084411
申请日：2006-11-02
申请人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人： Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号： C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译： 本发明涉及新的式（I）化合物。 式（I）其中可变基团如说明书和权利要求中所定义，含有它们的药物组合物，以及使用它们治疗癌症的方法。
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3.发明申请Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的取代的4-氨基 - 吡咯并嗪衍生物公开(公告)号：US20100063038A1
公开(公告)日：2010-03-11
申请号：US12085880
申请日：2006-12-01
申请人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
发明人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
IPC分类号： A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , C12N5/00 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及用作治疗高增殖和/或血管生成障碍的那些化合物或组合物作为唯一试剂或与其它活性成分组合的用途。
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4.发明申请SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权取代的4-氨基吡咯烷酮衍生物有助于治疗与增殖性疾病有关的高血压病和疾病公开(公告)号：US20120165314A1
公开(公告)日：2012-06-28
申请号：US13414392
申请日：2012-03-07
申请人： Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
发明人： Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
IPC分类号： A61K31/53 , A61P35/00 , A61K31/541 , A61K31/553 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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5.发明申请Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的替代的4-氨基 - 吡咯并嗪衍生物公开(公告)号：US20090281079A1
公开(公告)日：2009-11-12
申请号：US12085879
申请日：2006-11-30
申请人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
发明人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
IPC分类号： A61K31/553 , C07D487/04 , A61K31/53 , A61K31/5377 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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6.发明授权Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物公开(公告)号：US08133995B2
公开(公告)日：2012-03-13
申请号：US12085879
申请日：2006-11-30
申请人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
发明人： Julie Dixon , Steven Magnuson , Barton Phillips , Yamin Wang , Tandy Li , Kyle Parcella , Jason Newcom , Harold Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Kristen Allegue , Zheng Liu
IPC分类号： C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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7.发明申请Pyrrolotriazine Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的吡咯嗪衍生物公开(公告)号：US20070208013A1
公开(公告)日：2007-09-06
申请号：US11596913
申请日：2005-06-03
申请人： Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
发明人： Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/53 , C07D487/04
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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8.发明授权Pyrrolotriazine derivatives useful for treating cancer through inhibition of aurora kinase 有权用于通过抑制极光激酶治疗癌症的吡咯嗪衍生物公开(公告)号：US08338594B2
公开(公告)日：2012-12-25
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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9.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 有权用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物公开(公告)号：US20110021518A1
公开(公告)日：2011-01-27
申请号：US12085850
申请日：2006-12-01
申请人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
发明人： Steven Magnuson , Julie Dixon , Barton Phillips , Uday Khire , Lei Wang , Zhonghua Zhang , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Philip Wickens , Alan Olague
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/53 , C07D413/14 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US20050277640A1
公开(公告)日：2005-12-15
申请号：US11078681
申请日：2005-03-10
申请人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
发明人： Julie Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号： A61K31/506 , A61K31/5377 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D453/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要： Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译： 式（I）的嘧啶衍生物，其中J和Y代表芳族或杂芳族环; R 2，G，G'和G“表示取代基，R 2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物，以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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