公开(公告)号：US5773615A

公开(公告)日：1998-06-30

申请号：US600856

申请日：1996-02-13

申请人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

发明人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

IPC分类号： G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965 ,  Y10T436/25125

摘要： Method and apparatus for ion chromatography including passage of sample through a chromatographic separation column, through a suppressor column containing a resin with exchangeable ions, and then through a detector. The suppressor column is equipped with an electrical potential supplying device to electrolyze water and regenerate the suppressor column.

摘要翻译： 用于离子色谱法的方法和装置，包括样品通过色谱分离柱，通过含有可交换离子的树脂的抑制柱，然后通过检测器。 抑制柱配备有电解水并且再生抑制柱的电位供给装置。

公开(公告)号：US5633171A

公开(公告)日：1997-05-27

申请号：US397998

申请日：1995-03-03

申请人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

发明人： Hamish Small ,  John M. Riviello ,  Steven B. Rabin

IPC分类号： G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965 ,  Y10T436/25125

摘要： A method and apparatus for ion analysis by ion chromatography uses periodic electrolytic regeneration of a packed bed suppressor. First and second sets of columns, suppressors and detectors connected in series are linked by appropriate valving so that the effluent from the second suppressor can be passed to the first suppressor to be used in the electrolytic regeneration of the first suppressor after detection of analyte in the second detector.

摘要翻译： 通过离子色谱法进行离子分析的方法和装置使用填充床抑制剂的周期性电解再生。 串联连接的第一和第二组柱，抑制器和检测器通过适当的阀门连接，使得来自第二抑制器的流出物可以被传递到第一抑制器以用于在检测到第一抑制器的分析物的电解再生中 第二检测器。

公开(公告)号：US5569365A

公开(公告)日：1996-10-29

申请号：US398147

申请日：1995-03-03

申请人： Steven B. Rabin ,  Hamish Small ,  John M. Riviello

发明人： Steven B. Rabin ,  Hamish Small ,  John M. Riviello

IPC分类号： G01N30/02 ,  G01N30/60 ,  G01N30/96 ,  B01D15/08 ,  B01D61/48

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： A method and apparatus using suppression of eluents for the analysis of anions or cations in ion chromatography. The invention relates to the intermittent use of the electric field during electrochemical suppression to minimize background noise during detection of the ionic species caused by the application of an electric field using an electrolytic membrane suppressor. Using this intermittent electrochemical suppression system allows the detection of the analyte in the absence of the electric field. The system finds particular benefit in reducing background noise created during electrochemical suppression, and in reducing the baseline interference when analyzing organic solvent-containing samples.

摘要翻译： 在离子色谱法中使用抑制洗脱液进行阴离子或阳离子分析的方法和装置。 本发明涉及在电化学抑制期间间歇地使用电场，以使由使用电解膜抑制器的电场施加引起的离子物质检测期间的背景噪声最小化。 使用这种间歇电化学抑制系统允许在没有电场的情况下检测分析物。 该系统在减少电化学抑制期间产生的背景噪声以及在分析含有机溶剂的样品时降低基线干扰方面具有特别的益处。

公开(公告)号：US06495371B2

公开(公告)日：2002-12-17

申请号：US09877667

申请日：2001-06-08

申请人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

发明人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

IPC分类号： G11N3002

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： For anion analysis, the method includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through a separator bed, (b) flowing the aqueous effluent from the separator bed through a flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by a first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

摘要翻译： 对于阴离子分析，该方法包括：（a）将含有待检测的阴离子和阳离子氢氧化物的水性液体样品流通过分离床，（b）使来自分离器床的水性流出物流过流过抑制剂，（c 将来自抑制器的流出液体流过检测器，（d）将来自检测器的所述液体流出物再循环通过靠近抑制床的阴极室并被第一屏障隔开，并且（e）在阴极和 阳极。 在阳极处电解水以使阳离子交换树脂上的阳离子电致化学势垒，并将阴极室内的水转移至阴极，同时电解阴极室内的水，以产生氢氧化物离子，与运送的阳离子结合形成阳离子 氢氧化物在阴极室中。

公开(公告)号：US06610546B1

公开(公告)日：2003-08-26

申请号：US09648377

申请日：2000-08-25

申请人： Yan Liu ,  Kannan Srinivasan ,  Nebojsa Avdalovic ,  Hamish Small ,  John M. Riviello

发明人： Yan Liu ,  Kannan Srinivasan ,  Nebojsa Avdalovic ,  Hamish Small ,  John M. Riviello

IPC分类号： G01N3002

CPC分类号： G01N30/96 ,  G01N2030/965 ,  G01N30/6069

摘要： An electrolytic suppressor including (a) packing (a suppressor bed of ion exchange resin or a flow-through monolith), (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the packing from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the packing, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. Charged transverse partitions with openings may be included to create a serpentine liquid path. For anion analysis, the method of using the apparatus includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through the separator bed, (b) flowing the aqueous effluent from the separator bed through the flow-through packing, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the packing and separated by the first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange packing to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

摘要翻译： 一种电解抑制器，其包括（a）填充（离子交换树脂或流通式整料的抑制床），（b）与抑制器相邻的电极室，（c）电极室中的第一电极，（d） 将填料从第一电极室分离以防止显着的液体流动，但允许仅与填料相同的电荷输送离子，（e）与树脂床电连通的第二电极，和（f）抑制器之间的再循环导管 出口和所述电极室。 可以包括具有开口的带电的横向隔板以产生蛇形液体路径。 对于阴离子分析，使用该装置的方法包括：（a）使含有待检测的阴离子和阳离子氢氧化物的含水液体样品流通过分离床，（b）使来自分离器床的水性流出物流过流过 包装，（c）使来自抑制器的流出液体流过检测器，（d）将来自检测器的所述液体流出物循环通过邻近填料的阴极室并由第一屏障分离，以及（e） 阴极和阳极。 在阳极处电解阳极以使阳离子交换填料上的阳离子电迁移到屏障上，并将阴极室内的水转移到阴极，同时电解阴极室中的水以产生氢氧化物离子，这些氢离子与运送的阳离子结合形成阳离子 氢氧化物在阴极室中。

公开(公告)号：US06508985B2

公开(公告)日：2003-01-21

申请号：US09877666

申请日：2001-06-08

申请人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

发明人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

IPC分类号： G01N3002

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： An electrolyitic suppressor including (a) a suppressor bed of ion exchange resin, (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the suppressor bed from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the suppressor bed resin, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. The second electrode may be in contact with the ion exchange resin in the suppressor or located in second electrode chamber. For anion analysis, the method of using the apparatus includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through the separator bed, (b) flowing the aqueous effluent from the separator bed through the flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by the first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

摘要翻译： 一种电解抑制器，包括（a）离子交换树脂的抑制床，（b）与抑制器相邻的电极室，（c）电极室中的第一电极，（d）将抑制床与第一电极室 防止显着的液体流动，但允许仅与抑制床树脂相同的电荷的离子的输送，（e）与树脂床电连通的第二电极，和（f）在抑制器出口和电极室之间的再循环管道 。 第二电极可以与抑制器中的离子交换树脂接触或位于第二电极室中。 对于阴离子分析，使用该装置的方法包括：（a）使含有待检测的阴离子和阳离子氢氧化物的含水液体样品流通过分离床，（b）使来自分离器床的水性流出物流过流过 （c）将来自抑制器的流出液体流过检测器，（d）将来自检测器的所述液体流出物再循环通过靠近抑制床的阴极室并被第一屏障分离，以及（e）施加电势 在阴极和阳极之间。 在阳极处电解水以使阳离子交换树脂上的阳离子电致化学势垒，并将阴极室内的水转移至阴极，同时电解阴极室内的水，以产生氢氧化物离子，与运送的阳离子结合形成阳离子 氢氧化物在阴极室中。

公开(公告)号：US06325976B1

公开(公告)日：2001-12-04

申请号：US09031221

申请日：1998-02-26

申请人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

发明人： Hamish Small ,  Yan Liu ,  John M. Riviello ,  Nebojsa Avdalovic ,  Kannan Srinivasan

IPC分类号： G01N3002

摘要： An electrolyitic suppressor including (a) a suppressor bed of ion exchange resin, (b) an electrode chamber adjacent the suppressor, (c) a first electrode in the electrode chamber, (d) a barrier separating the suppressor bed from the first electrode chamber preventing significant liquid flow but permitting transport of ions only of the same charge as the suppressor bed resin, (e) a second electrode in electrical communication with the resin bed, and (f) a recycle conduit between the suppressor outlet port and said electrode chamber. The second electrode may be in contact with the ion exchange resin in the suppressor or located in second electrode chamber. For anion analysis, the method of using the apparatus includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through the separator bed, (b) flowing the aqueous effluent from the separator bed through the flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by the first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

摘要翻译： 一种电解抑制器，包括（a）离子交换树脂的抑制床，（b）与抑制器相邻的电极室，（c）电极室中的第一电极，（d）将抑制床与第一电极室 防止显着的液体流动，但允许仅与抑制床树脂相同的电荷的离子的输送，（e）与树脂床电连通的第二电极，和（f）在抑制器出口和电极室之间的再循环管道 。 第二电极可以与抑制器中的离子交换树脂接触或位于第二电极室中。 对于阴离子分析，使用该装置的方法包括：（a）使含有待检测的阴离子和阳离子氢氧化物的含水液体样品流通过分离床，（b）使来自分离器床的水性流出物流过流过 （c）将来自抑制器的流出液体流过检测器，（d）将来自检测器的所述液体流出物再循环通过靠近抑制床的阴极室并被第一屏障分离，以及（e）施加电势 在阴极和阳极之间。 在阳极处电解水以使阳离子交换树脂上的阳离子电致化学势垒，并将阴极室内的水转移至阴极，同时电解阴极室内的水，以产生氢氧化物离子，与运送的阳离子结合形成阳离子 氢氧化物在阴极室中。

公开(公告)号：US6027643A

公开(公告)日：2000-02-22

申请号：US145120

申请日：1998-09-02

申请人： Hamish Small ,  John M. Riviello ,  Yan Liu ,  Nebojsa Avdalovic

发明人： Hamish Small ,  John M. Riviello ,  Yan Liu ,  Nebojsa Avdalovic

IPC分类号： G01N30/02 ,  B01D15/08 ,  B01J39/26 ,  B01J41/20 ,  G01N30/34 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N30/34 ,  G01N2030/965

摘要： Disclosed is a method and apparatus for electrolytically generating an acid or base eluent in an aqueous solution and for simultaneously suppressing conductivity of the eluent in an ion exchange bed after chromatographic separation in an ion chromatography system.

摘要翻译： 公开了一种用于在离子色谱系统中色谱分离后在水溶液中电解产生酸或碱洗脱液并同时抑制离子交换床中的洗脱液的电导率的方法和装置。

公开(公告)号：US06316271B1

公开(公告)日：2001-11-13

申请号：US09470833

申请日：1999-12-23

申请人： Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

发明人： Hamish Small ,  Nebojsa Avdalovic ,  Yan Liu

IPC分类号： G01N3116

CPC分类号： B01J39/26 ,  B01J47/08 ,  G01N30/02 ,  G01N30/34 ,  G01N2030/407 ,  G01N2030/965 ,  Y10T436/117497 ,  B01D15/362

摘要： A method for generating high purity acid or base in an aqueous stream for use in analysis. For generating a base for anion chromatography, the aqueous stream is directed through a cation exchange bed having strongly acid first and weakly acidic second portions. An electrical potential is applied to the bed. Cations on the bed electromigrate into the aqueous stream while hydroxide ions are electrolytically generated to form a base-containing eluent. Analytes to be detected and the generated eluent flow through a detector.

摘要翻译： 一种在含水流中产生高纯度酸或碱的方法，用于分析。 为了产生用于阴离子色谱法的碱，水流通过具有强酸性第一和弱酸性第二部分的阳离子交换床。 电位施加到床上。 床上的阳离子电迁移到水流中，同时电解产生氢氧根离子以形成含碱的洗脱液。 待检测的分析物和产生的洗脱液流过检测器。

公开(公告)号：US5597734A

公开(公告)日：1997-01-28

申请号：US503999

申请日：1995-07-19

申请人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

发明人： Hamish Small ,  John Riviello ,  Christopher A. Pohl

IPC分类号： A61B17/60 ,  A61B17/64 ,  G01N30/02 ,  G01N30/60 ,  G01N30/96

CPC分类号： G01N30/96 ,  G01N2030/965

摘要： An ion chromatography method for analysis of a plurality of analyte ions in a sequence of samples in which ion chromatography is performed on a sample, which is passed to a non-precipitating suppressor ion exchange resin and analyzed, the suppressor being regenerated in one step prior to processing of a subsequent sample.

摘要翻译： 一种用于分析样品序列中的多个分析物离子的离子色谱法，其中对样品进行离子色谱，所述样品被传递到非沉淀抑制离子交换树脂，并分析了在一个步骤中再生的抑制剂 以处理随后的样品。