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1.Probes and assays for calcium channel .alpha..sub.2 subunit-encoding nucleic acids 失效
标题翻译: 钙通道α2亚基编码核酸的探针和测定公开(公告)号:US5686241A
公开(公告)日:1997-11-11
申请号:US314083
申请日:1994-09-28
申请人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Arnold Schwartz , Robert Brenner
发明人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Arnold Schwartz , Robert Brenner
IPC分类号: C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/566 , G01N33/68
CPC分类号: G01N33/566 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , G01N2333/435 , G01N2333/705
摘要: Calcium channel (alpha).sub.1 -subunit and (alpha).sub.2 -subunit-encoding DNA, and related compositions and methods, are provided.
摘要翻译: 提供了钙通道(α)1-亚基和(α)2-亚基编码DNA,以及相关组合物和方法。
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公开(公告)号:US6013474A
公开(公告)日:2000-01-11
申请号:US884599
申请日:1997-06-27
申请人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Arnold Schwartz , Robert Brenner
发明人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Arnold Schwartz , Robert Brenner
IPC分类号: C12N1/19 , C07K14/00 , C07K14/47 , C07K14/705 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/645 , G01N33/564 , G01N33/68
CPC分类号: C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/564 , G01N33/68 , G01N33/6872 , G01N33/6893 , C12Q2600/158
摘要: Calcium channel (alpha).sub.1 -subunit and (alpha).sub.2 -subunit-encoding DNA, and related compositions and methods, are provided.
摘要翻译: 提供了钙通道(α)1-亚基和(α)2-亚基编码DNA,以及相关组合物和方法。
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公开(公告)号:US5710250A
公开(公告)日:1998-01-20
申请号:US435675
申请日:1995-05-05
申请人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Jean Sartor , Robert Brenner
发明人: Steven Bradley Ellis , Mark E. Williams , Michael Miller Harpold , Jean Sartor , Robert Brenner
IPC分类号: C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/566 , G01N33/68 , C07K14/435 , C12N15/85
CPC分类号: G01N33/566 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , G01N2333/435 , G01N2333/705
摘要: .alpha..sub.1 - and .alpha..sub.2 - protein subunits of voltage-dependent calcium channels are provided.
摘要翻译: 提供电压依赖性钙通道的α1-和α2-蛋白质亚基。
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4.Cells expressing calcium channel .alpha.2 subunit-encoding DNA, optionally with a reporter gene for screening assays 失效
标题翻译: 表达钙通道α2亚基编码DNA的细胞,任选与报告基因进行筛选测定公开(公告)号:US5618720A
公开(公告)日:1997-04-08
申请号:US404354
申请日:1995-02-15
申请人: Steven B. Ellis , Mark E. Williams , Michael M. Harpold , Arnold Schwartz , Jean Sartor , Robert Brenner
发明人: Steven B. Ellis , Mark E. Williams , Michael M. Harpold , Arnold Schwartz , Jean Sartor , Robert Brenner
IPC分类号: C12N1/19 , C07K14/00 , C07K14/47 , C07K14/705 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/645 , G01N33/564 , G01N33/68 , G01N33/50
CPC分类号: C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/564 , G01N33/68 , G01N33/6872 , G01N33/6893 , C12Q2600/158
摘要: [DNAs] DNA molecules encoding mammalian calcium channel a.sub.1 and a.sub.2 subunits are provided. The [DNAs] DNA molecules are used to transform host cells which may also contain a reporter gene, the transcription of which is responsive to an ion or molecule capable of entering the cell through a calcium channel.
摘要翻译: [DNAs]提供编码哺乳动物钙通道a1和a2亚基的DNA分子。 [DNAs] DNA分子用于转化也可含有报告基因的宿主细胞,该基因的转录对能通过钙通道进入细胞的离子或分子起反应。
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5.
公开(公告)号:US5407820A
公开(公告)日:1995-04-18
申请号:US914231
申请日:1992-07-13
IPC分类号: C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/566 , G01N33/68 , C12N5/10 , C12N15/89
CPC分类号: G01N33/566 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , G01N2333/435 , G01N2333/705
摘要: Calcium channel .alpha..sub.1 -subunit and .alpha..sub.2 -subunit-encoding cDNAs, and related compositions and methods, are provided.
摘要翻译: 提供钙通道α1亚基和α2亚基编码cDNA,以及相关组合物和方法。
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公开(公告)号:US5792846A
公开(公告)日:1998-08-11
申请号:US455543
申请日:1995-05-31
申请人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号: A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C07H21/04
CPC分类号: G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
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7.Human calcium channel .alpha.-1C/.alpha.-1D, .alpha.-2, .beta.-1, and .gamma.subunits and cells expressing the DNA 失效
标题翻译: 人钙通道α-1 /α-1D,α-2,β-1和γ亚基以及表达DNA的细胞公开(公告)号:US5851824A
公开(公告)日:1998-12-22
申请号:US223305
申请日:1994-04-04
申请人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号: A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C07K14/435
CPC分类号: G01N33/6893 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , A61K38/00 , C12Q2600/158
摘要: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
摘要翻译: 提供了编码人钙通道α1-,α2-,β-和γ-亚基的每一个的分离的DNA,包括作为初级转录物的剪接变体产生的亚单位。 还提供了含有DNA的细胞和载体以及用于鉴定调节人钙通道活性的化合物的方法。
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8.Human calcium channel .alpha..sub.1, .alpha..sub.2, and .beta. subunits and assays using them 失效
标题翻译: 人钙通道α1,α2和β亚基和使用它们的测定公开(公告)号:US5846757A
公开(公告)日:1998-12-08
申请号:US193078
申请日:1994-02-07
申请人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号: A61K38/00 , C07K14/705 , C12Q1/68 , G01N33/564 , G01N33/68 , C12Q1/02
CPC分类号: C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/136 , C12Q2600/158
摘要: Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
摘要翻译: PCT No.PCT / US92 / 06903 Sec。 371日期1994年2月7日 102(e)1994年2月7日PCT PCT 1992年8月14日PCT公布。 出版物WO93 / 04083 日期1993年3月4日提供了编码人钙通道α1-,α2-,β-和γ-亚基的各自的DNA,包括作为初级转录物的剪接变体产生的亚单位。 还提供了含有DNA的细胞和载体以及用于鉴定调节人钙通道活性的化合物的方法。
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9.Assays of cells expressing human calcium channels containing .alpha..sub.1 .beta. subunits 失效
标题翻译: 表达含有α1b亚基的人钙通道的细胞的测定公开(公告)号:US5876958A
公开(公告)日:1999-03-02
申请号:US311363
申请日:1994-09-23
申请人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号: A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C12Q1/02
CPC分类号: G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要: Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
摘要翻译: 提供人钙通道α1-,α2-,β-和γ-亚基编码cDNA,以及相关组合物和方法。
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公开(公告)号:US07414110B2
公开(公告)日:2008-08-19
申请号:US11702388
申请日:2007-02-05
申请人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Ann F. McCue , Alison Gillespie , Daniel H. Feldman , Robert Brenner
发明人: Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Ann F. McCue , Alison Gillespie , Daniel H. Feldman , Robert Brenner
IPC分类号: C07K14/435 , C07K14/705 , C12P21/02 , A61K38/17
CPC分类号: C07K14/705 , C12Q1/6876 , C12Q2600/158 , G01N33/564 , G01N33/68
摘要: Isolated DNA encoding each of human calcium channel α1-, α2-, β- and γ-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
摘要翻译: 提供了编码人钙通道α1 - ,α2 - ,β-和γ-亚单位的分离的DNA,包括作为初级转录物的剪接变体产生的亚基 。 还提供了含有DNA的细胞和载体以及用于鉴定调节人钙通道活性的化合物的方法。
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