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    High throughput screening of potential displacer molecules
    1.
    发明申请
    High throughput screening of potential displacer molecules 审中-公开
    潜在置换剂分子的高通量筛选

    公开(公告)号：US20050176937A1

    公开(公告)日：2005-08-11

    申请号：US11103293

    申请日：2005-04-11

    申请人： Steven Cramer ,  Kaushal Rege ,  Jonathan Dordick ,  Nihal Tugcu

    发明人： Steven Cramer ,  Kaushal Rege ,  Jonathan Dordick ,  Nihal Tugcu

    IPC分类号： B01D15/42 ,  C07K1/22 ,  C07H21/04 ,  C07K1/10

    CPC分类号： B01D15/422 ,  C07K1/22

    摘要： A bioproduct may be selectively separated from one or more impurities by means of a displacement chromatography system that includes a solvent, a chromatographic resin and a chemically selective displacer. The method includes: dissolving the bioproduct and the one or more impurities in a solvent; loading the bioproduct and the one or more impurities, in the solvent, on a chromatographic resin; displacing the bioproduct from the chromatographic resin with chemically selective displacer; and retaining the one or more impurities on the chromatographic resin. For this method, the bioproduct and the impurities have similar binding affinity for the chromatographic resin in the absence of the displacer.

    摘要翻译： 生物产物可以通过置换色谱系统选择性地与一种或多种杂质分离，所述置换色谱系统包括溶剂，色谱树脂和化学选择性置换器。 该方法包括：将生物产物和一种或多种杂质溶解在溶剂中; 在溶剂中将生物产物和一种或多种杂质装载在色谱树脂上; 用化学选择性置换器置换色谱树脂的生物产物; 并将一种或多种杂质保留在色谱树脂上。 对于该方法，生物产物和杂质在没有置换剂的情况下对色谱树脂具有相似的结合亲和力。