公开(公告)号：US07189324B1

公开(公告)日：2007-03-13

申请号：US11148887

申请日：2005-06-08

申请人： Steven M. Cramer ,  James A. Moore ,  Sun Kyu Park ,  Nihal Tugcu

发明人： Steven M. Cramer ,  James A. Moore ,  Sun Kyu Park ,  Nihal Tugcu

IPC分类号： B01D15/08

CPC分类号： B01D15/361 ,  B01D15/422 ,  C07K1/18

摘要： A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a second solution including a displacer having a structure selected from formula I and formula II:

摘要翻译： 通过以位移模式操作的离子交换色谱系统分离生物分子混合物的一种或多种组分的方法包括用包括生物分子混合物的第一溶液依次灌注该系统，以及第二溶液，其包括具有选择的结构的置换器 由式I和式II得出：

公开(公告)号：US06929747B2

公开(公告)日：2005-08-16

申请号：US10377080

申请日：2003-02-28

申请人： Steven M. Cramer ,  James A. Moore ,  Sun Kyu Park ,  Nihal Tugcu

发明人： Steven M. Cramer ,  James A. Moore ,  Sun Kyu Park ,  Nihal Tugcu

IPC分类号： B01D15/36 ,  B01D15/42 ,  B01D15/08

CPC分类号： B01D15/361 ,  B01D15/422 ,  C07K1/18

摘要： A method for separating one or more components of a biomolecule mixture by means of an ion exchange chromatographic system operated in the displacement mode includes sequentially perfusing the system with a first solution including the biomolecule mixture, and a second solution including a displacer having a structure selected from formula I and formula II:

摘要翻译： 通过以位移模式操作的离子交换色谱系统分离生物分子混合物的一种或多种组分的方法包括用包括生物分子混合物的第一溶液依次灌注该系统，以及第二溶液，其包括具有选择的结构的置换器 由式I和式II得出：

公开(公告)号：US06828436B2

公开(公告)日：2004-12-07

申请号：US10146266

申请日：2002-05-15

申请人： Abhinav A. Shukla ,  Ranjit R. Deshmukh ,  Steven M. Cramer ,  James A. Moore

发明人： Abhinav A. Shukla ,  Ranjit R. Deshmukh ,  Steven M. Cramer ,  James A. Moore

IPC分类号： C07H2100

CPC分类号： C12N15/101 ,  B01D15/422

摘要： A method for purifying oligonucleotides by displacement chromatography on anion-exchange media, using high affinity, low molecular weight (less than about 10000 Da) displacers, is disclosed. Several examples of high affinity, low molecular weight anionic displacers are provided, including polycyclic aromatic compounds having sulfonic acid moieties attached thereon. The efficacy of the technique for high resolution separation of oligonucleotides is demonstrated for an industrial mixture.

摘要翻译： 公开了使用高亲和力，低分子量（小于约10000Da）置换剂在阴离子交换介质上通过置换色谱法纯化寡核苷酸的方法。 提供了高亲和性，低分子量阴离子置换剂的几个实例，包括其上连接有磺酸基团的多环芳族化合物。 该技术用于高分辨率分离寡核苷酸的功效证明了工业混合物。

公开(公告)号：US5478924A

公开(公告)日：1995-12-26

申请号：US197146

申请日：1994-02-16

申请人： Steven M. Cramer ,  James A. Moore ,  Amitava Kundu ,  Yufei Li ,  Guhan Jayaraman

发明人： Steven M. Cramer ,  James A. Moore ,  Amitava Kundu ,  Yufei Li ,  Guhan Jayaraman

IPC分类号： C07C217/08 ,  B01D15/42 ,  C07C215/40 ,  C07K1/18 ,  G01N30/02 ,  C07K1/14 ,  C07C211/62 ,  C07K1/16

CPC分类号： B01D15/422 ,  C07C215/40 ,  C07K1/18 ,  G01N30/02

摘要： A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight, charged species are exemplified, including aminoacids, peptides, antibiotics and dendrimeric polymers. Novel compounds useful as displacers are dendrimers of formula ##STR1## wherein R.sup.1 is lower alkyl, n is 2 to 6, and X is a common counter anion and similar dendritic polymers based thereon.

摘要翻译： 公开了一种使用低分子量置换器在离子交换介质上通过置换色谱法纯化蛋白质的方法。 例举了几类低分子量带电物质，包括氨基酸，肽，抗生素和树枝状聚合物。 可用作置换剂的新型化合物是式“IMAGE”的树枝状大分子，其中R 1是低级烷基，n是2-6，X是常见的抗衡阴离子和类似的树枝状聚合物。

公开(公告)号：US06573373B1

公开(公告)日：2003-06-03

申请号：US09343006

申请日：1999-06-29

申请人： Abhinav A. Shukla ,  Ranjit R. Deshmukh ,  Steven M. Cramer ,  James A. Moore

发明人： Abhinav A. Shukla ,  Ranjit R. Deshmukh ,  Steven M. Cramer ,  James A. Moore

IPC分类号： C07H2100

CPC分类号： C12N15/101 ,  B01D15/422

摘要： A method for purifying oligonucleotides by displacement chromatography on anion-exchange media, using high affinity, low molecular weight (less than about 10000 Da) displacers, is disclosed. Several examples of high affinity, low molecular weight anionic displacers are provided, including polycyclic aromatic compounds having sulfonic acid moieties attached thereon. The efficacy of the technique for high resolution separation of oligonucleotides is demonstrated for an industrial mixture.

公开(公告)号：US5606033A

公开(公告)日：1997-02-25

申请号：US545457

申请日：1995-10-19

申请人： Steven M. Cramer ,  James A. Moore ,  Amitava Kundu ,  Yufei Li ,  Guhan Jayaraman

发明人： Steven M. Cramer ,  James A. Moore ,  Amitava Kundu ,  Yufei Li ,  Guhan Jayaraman

IPC分类号： C07C217/08 ,  B01D15/42 ,  C07C215/40 ,  C07K1/18 ,  G01N30/02 ,  C07K1/14 ,  C07K1/16

CPC分类号： B01D15/422 ,  C07C215/40 ,  C07K1/18 ,  G01N30/02

摘要： A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight anionic species are exemplified, including aromatic rings having sulfonic acid or carboxylic acid moieties attached thereon, sulfated sugar derivatives, anionic antibiotics, and dendrimeric polymers. Novel compounds useful as displacers are dendrimers of formula ##STR1## wherein R.sup.1 is lower alkyl, n is 2 to 6 and similar dendritic polymers based thereon.

摘要翻译： 公开了一种使用低分子量置换器在离子交换介质上通过置换色谱法纯化蛋白质的方法。 例举了几类低分子量阴离子物质，包括其上连接有磺酸或羧酸部分的芳香环，硫酸化糖衍生物，阴离子抗生素和树枝状聚合物。 用作置换剂的新型化合物是基于其的式和类似树枝状聚合物的树枝状大分子。

公开(公告)号：US07859464B2

公开(公告)日：2010-12-28

申请号：US12609856

申请日：2009-10-30

申请人： Stephen F. Smith ,  James A. Moore

发明人： Stephen F. Smith ,  James A. Moore

IPC分类号： G01S3/02

CPC分类号： G01C21/165 ,  G01C21/206 ,  G01S1/042 ,  G01S1/24 ,  G01S5/0263 ,  G01S5/10 ,  G01S19/10 ,  G01S19/18 ,  G01S19/47

摘要： Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference.

摘要翻译： 为导航系统描述了方法和装置。 一种过程包括提供分布在整个所需覆盖区域内的多个发射机; 将所述多个发射机锁定到公共定时参考; 从所述多个发射机中的每一个发送信号。 一种装置包括分布在期望覆盖区域内的多个发射机; 其中所述多个发射机中的每一个包括分组发生器; 并且其中所述多个发射器被锁定到公共定时参考。

公开(公告)号：US20100103046A1

公开(公告)日：2010-04-29

申请号：US12609883

申请日：2009-10-30

申请人： Stephen F. Smith ,  James A. Moore

发明人： Stephen F. Smith ,  James A. Moore

IPC分类号： G01S1/08

CPC分类号： G01C21/165 ,  G01C21/206 ,  G01S1/042 ,  G01S1/24 ,  G01S5/0263 ,  G01S5/10 ,  G01S19/10 ,  G01S19/18 ,  G01S19/47

摘要： Methods and apparatus are described for a navigation system. A process includes providing a plurality of transmitters distributed throughout a desired coverage area; locking the plurality of transmitters to a common timing reference; transmitting a signal from each of the plurality of transmitters. An apparatus includes a plurality of transmitters distributed throughout a desired coverage area; wherein each of the plurality of transmitters comprises a packet generator; and wherein the plurality of transmitters are locked to a common timing reference.

公开(公告)号：US4877718A

公开(公告)日：1989-10-31

申请号：US249393

申请日：1988-09-26

申请人： James A. Moore ,  Andrew N. Dasheff ,  Frank B. Kaufman

发明人： James A. Moore ,  Andrew N. Dasheff ,  Frank B. Kaufman

IPC分类号： C09D179/08 ,  G03F7/038 ,  G03F7/039 ,  H01L21/027

CPC分类号： G03F7/039 ,  Y10S430/107

摘要： An insoluble photosensitive polyimide having the formula ##STR1## can be exposed by a pattern of light to render the exposed areas soluble. The exposed areas can then be dissolved using a solvent to leave the pattern which can be used directly as an insulator layer in a semiconductor device. A process for preparing the photosensitive soluble polyimide utilizes maleic anhydride which is irradiated by ultraviolet light to form a cyclobutane unit which is reacted with oxydianiline to form polymic acid. The polymic acid is cured using heat into the photosensitive soluble polyimide.

公开(公告)号：US4213937A

公开(公告)日：1980-07-22

申请号：US726018

申请日：1976-09-22

申请人： Francois A. Padovani ,  Michael B. Miller ,  James A. Moore ,  James H. Fowler ,  Malcom N. June ,  James D. Matthews ,  T. R. Morton ,  Norbert A. Stotko ,  Lewis B. Palmer

发明人： Francois A. Padovani ,  Michael B. Miller ,  James A. Moore ,  James H. Fowler ,  Malcom N. June ,  James D. Matthews ,  T. R. Morton ,  Norbert A. Stotko ,  Lewis B. Palmer

IPC分类号： B01J8/18 ,  C01B33/02 ,  C01B33/00

CPC分类号： B01J8/1836 ,  C01B33/02 ,  B01J2208/00132 ,  B01J2208/00194 ,  B01J2208/00274 ,  B01J2208/00371 ,  B01J2208/00407 ,  B01J2208/00415 ,  B01J2208/0053

摘要： A balanced, closed cycle silicon refinery system has been developed for producing electronic grade silicon from industrial grade silicon. Impurities comprising approximately 1% of the industrial grade silicon are removed in the refinery system to produce the purified silicon, while only a relatively small percentage of make-up chemicals are added to the system. In the refinery, hydrogen chloride is reacted with the impure silicon in a halide reactor to provide trichlorosilane and silicon tetrachloride and hydrogen. The trichlorosilane and/or silicon tetrachloride are passed through purification means, and then reacted with the hydrogen from the halide reactor in a fluidized bed reactor to produce the purified silicon and an effluent comprised of unreacted trichlorosilane, silicon tetrachloride, hydrogen, and the by-product hydrogen chloride. These materials are passed through a separator and the trichlorosilane and silicon tetrachloride and hydrogen are returned to the silicon reactor while the hydrogen chloride is returned to the halide reactor to be reacted with additional industrial grade silicon.

摘要翻译： 已经开发了一种平衡的封闭循环硅精炼系统，用于从工业级硅生产电子级硅。 包含大约1％的工业级硅的杂质在炼油系统中被除去以产生纯化的硅，而仅将相对小百分比的化妆品添加到系统中。 在炼油厂，氯化氢与卤化物反应器中的不纯硅反应，得到三氯硅烷和四氯化硅和氢气。 三氯硅烷和/或四氯化硅通过纯化装置，然后在流化床反应器中与来自卤化物反应器的氢气反应，以产生纯化的硅和由未反应的三氯硅烷，四氯化硅，氢气和副产物组成的流出物， 产物氯化氢。 将这些材料通过分离器，并将三氯硅烷和四氯化硅和氢气返回到硅反应器，同时氯化氢返回到卤化物反应器以与另外的工业级硅反应。