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公开(公告)号：US5665720A
公开(公告)日：1997-09-09
申请号：US458529
申请日：1995-06-02
IPC分类号： A61K31/535 , A61K31/536 , A61K45/06 , C07D265/18
CPC分类号： C07D265/18 , A61K31/535 , A61K31/536 , A61K31/70 , A61K45/06 , Y10S514/934
摘要： Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 某些苯并恶嗪酮可用于抑制HIV逆转录酶（包括其抗性品种），预防或治疗艾滋病毒感染和艾滋病治疗，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与 其他抗病毒药物，免疫调节剂，抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5519021A
公开(公告)日：1996-05-21
申请号：US460026
申请日：1995-06-02
IPC分类号： A61K31/535 , A61K31/536 , A61K45/06 , C07D265/18
CPC分类号： C07D265/18 , A61K31/535 , A61K31/536 , A61K31/70 , A61K45/06 , Y10S514/934
摘要： Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 某些苯并恶嗪酮可用于抑制HIV逆转录酶（包括其抗性品种），预防或治疗艾滋病毒感染和治疗艾滋病，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与 其他抗病毒药，免疫调节剂，抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5811423A
公开(公告)日：1998-09-22
申请号：US815780
申请日：1997-03-12
IPC分类号： A61K31/535 , A61K31/536 , A61K45/06 , C07D265/18
CPC分类号： C07D265/18 , A61K31/535 , A61K31/536 , A61K31/70 , A61K45/06 , Y10S514/934
摘要： Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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公开(公告)号：US5663169A
公开(公告)日：1997-09-02
申请号：US458528
申请日：1995-06-02
IPC分类号： A61K31/535 , A61K31/536 , A61K45/06 , C07D265/18
CPC分类号： C07D265/18 , A61K31/535 , A61K31/536 , A61K31/70 , A61K45/06 , Y10S514/934
摘要： Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable saks, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 某些苯并恶嗪酮可用于抑制HIV逆转录酶（包括其抗性品种），预防或治疗艾滋病毒感染和艾滋病治疗，作为化合物，药学上可接受的saks，药物组合物成分，无论是否与 其他抗病毒药，免疫调节剂，抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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5.发明授权Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors 失效二氨基异噻唑-1-氧化物和1,1-二氧化物作为胃分泌抑制剂
公开(公告)号：US5171860A
公开(公告)日：1992-12-15
申请号：US794339
申请日：1991-11-12
IPC分类号： C07D275/02 , C07D275/03 , C07D277/48 , C07F7/10 , C07F7/18
CPC分类号： C07D275/03 , C07C255/00 , C07D277/48 , C07F7/10 , C07F7/1896
摘要： This invention is directed to diamino isothiazole -1-oxides and -1,1-dioxides and related compounds as well as pharmaceutical compositions and methods useful in the treatment of gastric secretion in mammals.
摘要翻译： 本发明涉及二氨基异噻唑-1-氧化物和-1,1-二氧化物及相关化合物以及可用于治疗哺乳动物胃分泌的药物组合物和方法。
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公开(公告)号：US4772622A
公开(公告)日：1988-09-20
申请号：US874757
申请日：1986-06-16
IPC分类号： C07D271/06 , C07D271/07 , A61K31/41 , A61K31/535 , C07D413/02
CPC分类号： C07D271/07
摘要： Novel diamino oxadiazoles, wherein one of the amine functions is connected to a basicly-substituted heterocyclic group through a linear or cyclic connecting group, which are useful for the suppression of gastric acid secretions in mammals. Compositions employing these compounds and processes for the preparation of such compounds from known N-cyano-S-methylisothiourea precursors by treatment with hydroxylamine and for alkylation of amine groups are also disclosed.
摘要翻译： 新的二氨基恶二唑，其中一个胺官能团通过线性或环状连接基团与碱取代的杂环基连接，其可用于抑制哺乳动物中的胃酸分泌。 还公开了使用这些化合物的组合物和通过用羟胺处理和胺基烷基化从已知的N-氰基-S-甲基异硫脲前体制备这些化合物的方法。
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公开(公告)号：US4056536A
公开(公告)日：1977-11-01
申请号：US700921
申请日：1976-06-29
IPC分类号： C07D207/34 , C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D207/34
摘要： 11H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-styrylpyrrole-2-carboxylic acid derivative. They are useful intermediates in the synthesis of skeletal muscle relaxants and tranquilizers such as 11-(3-dimethylaminopropylidene)-2-cyano-11H-pyrrolo[2,1-b][3]benzazepine.
摘要翻译： 11H-吡咯并[2,1-b] [3]苯并吖庚因-11-酮及其衍生物通常通过Friedel-Crafts环闭合N-苯乙烯基吡咯-2-羧酸衍生物制备。 它们是合成骨骼肌松弛剂和镇定剂如11-（3-二甲基氨基亚丙基）-2-氰基-11H-吡咯并[2,1-b] [3]苯并氮杂的有用中间体。
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8.发明授权Derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine 失效5-甲基-10,11-二氢-5H-二苯并[a，d]环庚烯-5,10-亚胺的衍生物
公开(公告)号：US4870079A
公开(公告)日：1989-09-26
申请号：US175469
申请日：1988-03-30
IPC分类号： C07D451/02 , C07D471/08
CPC分类号： C07D451/00 , C07D451/02 , C07D471/08
摘要： Fluoro-and hydroxy-derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines wherein the substituents are on non-benzenoid carbons are active anticonvulsants and antagonists of N-methyl-D-aspartate.
摘要翻译： 5-甲基-10,11-二氢-5H-二苯并[a，d]环庚烯-5,10-亚胺的氟 - 和羟基衍生物，其中取代基在非苯甲碳原子上是N-甲基的活性抗惊厥药和拮抗剂 -D天冬氨酸
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公开(公告)号：US5502053A
公开(公告)日：1996-03-26
申请号：US294772
申请日：1994-08-23
申请人： Bruce D. Dorsey , Joel R. Huff , Susan F. Britcher
发明人： Bruce D. Dorsey , Joel R. Huff , Susan F. Britcher
IPC分类号： C07C235/26 , C07C235/36 , C07C235/78 , C07C251/38 , C07D295/092 , C07D307/14 , C07D335/06 , A61K31/395 , C07D265/28
CPC分类号： C07D295/088 , C07C235/26 , C07C235/36 , C07C235/78 , C07C251/38 , C07D307/14 , C07D335/06 , C07C2101/14 , C07C2102/08
摘要： Compounds of formula ##STR1## are HIV protease inhibitors, and are synthesized via a novel route. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 式“IMAGE”的化合物是HIV蛋白酶抑制剂，并通过新的途径合成。 这些化合物可用于预防或治疗HIV的感染和治疗AIDS，无论是作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US4996211A
公开(公告)日：1991-02-26
申请号：US231295
申请日：1988-08-12
申请人： Raymond Baker , Paul D. Leeson , Susan F. Britcher
发明人： Raymond Baker , Paul D. Leeson , Susan F. Britcher
IPC分类号： A61K31/435 , A61K31/46 , A61P3/08 , A61P9/00 , A61P9/08 , A61P25/00 , A61P25/08 , A61P25/28 , C07C67/00 , C07C239/00 , C07C239/08 , C07D451/00
CPC分类号： C07D451/00
摘要： The present invention provides a compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represents a hydrocarbon or hydrocarbyloxycarbonyl group and the remaining groups R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, hydrocarbon, hydrocarbyloxycarbonyl, halogen, hydroxy or C.sub.1-6 alkoxy, or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 may together represent the residue of a carbocyclic ring; R.sup.5 and R.sup.6 independently represent hydrogen, hydrocarbon, hydroxy or fluoro; R.sup.7 represents hydrogen or C.sub.1-3 alkyl; and R.sup.8 represents methyl or ethyl; which compounds are useful as anticonvulsant agents and in the treatment of neurodegenerative diseases.
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