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    COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE
    1.
    发明申请
    COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 审中-公开
    CD28结合的组合物单一使用方法和使用方法

    公开(公告)号：US20130230540A1

    公开(公告)日：2013-09-05

    申请号：US13545795

    申请日：2012-07-10

    申请人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    发明人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    IPC分类号： C07K16/28

    CPC分类号： C07K16/2896 ,  C07K16/2818 ,  C07K2317/569

    摘要： The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a monovalent anti-CD28 antibody single variable domain to the individual.

    摘要翻译： 本公开涉及特异性结合CD28的单价多肽结构域以及CD28拮抗剂，其中拮抗剂包含特异性结合CD28的单价多肽结构域。 本公开内容涵盖包含单价结合CD28的抗体单可变结构域的单价多肽结构域。 用于结合CD28的单价抗体单可变区可抑制CD28活性。 在一个方面，单价抗CD28抗体单可变结构域由一个方面组成或包含特异性结合和拮抗CD28的活性的抗体单可变结构域，而不具有实质上激动的CD28活性。 另一方面，单价抗CD28抗体单可变结构域是人抗体单可变结构域。 本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及CD80和/或CD86与CD28相互作用的疾病或病症的方法，涉及向单克隆抗CD28抗体单可变结构域施用的方法 个人。

    Compositions monovalent for CD28 binding and methods of use
    2.
    发明申请
    Compositions monovalent for CD28 binding and methods of use 审中-公开
    用于CD28结合的单价组合物和使用方法

    公开(公告)号：US20110097339A1

    公开(公告)日：2011-04-28

    申请号：US12456703

    申请日：2009-06-18

    申请人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    发明人： Steven Holmes ,  Carrie Enever ,  Steven Grant ,  David Sansom

    IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  A61P11/06 ,  A61P37/08 ,  A61P35/00 ,  A61P31/00

    CPC分类号： C07K16/2896 ,  C07K16/2818 ,  C07K2317/569

    摘要： The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a monovalent anti-CD28 antibody single variable domain to the individual.

    摘要翻译： 本公开涉及特异性结合CD28的单价多肽结构域以及CD28拮抗剂，其中拮抗剂包含特异性结合CD28的单价多肽结构域。 本公开内容涵盖包含单价结合CD28的抗体单可变结构域的单价多肽结构域。 用于结合CD28的单价抗体单可变区可抑制CD28活性。 在一个方面，单价抗CD28抗体单可变结构域由一个方面组成或包含特异性结合和拮抗CD28的活性的抗体单可变结构域，而不具有实质上激动的CD28活性。 另一方面，单价抗CD28抗体单可变结构域是人抗体单可变结构域。 本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及CD80和/或CD86与CD28相互作用的疾病或病症的方法，涉及向单克隆抗CD28抗体单可变结构域施用的方法 个人。