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    Amino acid modified polypeptides
    7.
    发明申请
    Amino acid modified polypeptides 审中-公开
    氨基酸修饰的多肽

    公开(公告)号：US20060178506A1

    公开(公告)日：2006-08-10

    申请号：US11048197

    申请日：2005-02-01

    申请人： Elliott Gruskin ,  Douglas Buechter ,  Guanghui Zhang ,  Kevin Connolly

    发明人： Elliott Gruskin ,  Douglas Buechter ,  Guanghui Zhang ,  Kevin Connolly

    IPC分类号： C07H21/04

    CPC分类号： C12P21/02 ,  C07K14/51 ,  C07K14/78 ,  C07K2319/00

    摘要： Incorporation of certain amino acid analogs into polypeptides produced by cells which do not-ordinarily provide polypeptides containing such amino acid analogs is accomplished by subjecting the cells to growth media containing such amino acid analogs. The degree of incorporation can be regulated by adjusting the concentration of amino acid analogs in the media and/or by adjusting osmolality of the media. Such incorporation allows the chemical and physical characteristics of polypeptides to be altered and studied. In addition, nucleic acid and corresponding proteins including a domain from a physiologically active peptide and a domain from an extracellular matrix protein which is capable of providing a self-aggregate are provided. Human extracellular matrix proteins capable of providing a self-aggregate collagen are provided which are produced by prokaryotic cells. Preferred codon usage is employed to produce extracellular matrix proteins in prokaryotics.

    摘要翻译： 将某些氨基酸类似物并入通常不提供含有这种氨基酸类似物的多肽的细胞产生的多肽中，是通过使细胞经受含有这种氨基酸类似物的生长培养基来完成的。 可以通过调节培养基中氨基酸类似物的浓度和/或通过调节培养基的重量摩尔渗透压浓度来调节掺入程度。 这种结合允许改变和研究多肽的化学和物理特性。 此外，提供核酸和相应的蛋白质，包括来自生理活性肽的结构域和能够提供自聚集体的细胞外基质蛋白的结构域。 提供能够提供自身骨胶原蛋白的人细胞外基质蛋白，其由原核细胞产生。 使用优选的密码子用于在原核生物中产生细胞外基质蛋白。

    BONE CEMENT WITH ADAPTED MECHANICAL PROPERTIES
    8.
    发明申请
    BONE CEMENT WITH ADAPTED MECHANICAL PROPERTIES 有权
    具有适应机械性能的骨水泥

    公开(公告)号：US20100056654A1

    公开(公告)日：2010-03-04

    申请号：US12529562

    申请日：2008-02-29

    申请人： Elliott Gruskin ,  Andreas Boger ,  Andrea Montali ,  Kurtis Wheeler

    发明人： Elliott Gruskin ,  Andreas Boger ,  Andrea Montali ,  Kurtis Wheeler

    IPC分类号： C08J9/28 ,  C08L33/12

    CPC分类号： A61L24/0084 ,  A61L24/0036 ,  A61L24/0094 ,  A61L24/06 ,  A61L2430/02 ,  C08L33/12

    摘要： A bone cement is shown that includes a monomer, and a non-reactive substance that is fully miscible with the monomer. A resulting cured bone cement exhibits desirable properties such as modification in a stiffness of the material. Modified properties such a stiffness can be tailored to match bone properties and reduce an occurrence of fractures adjacent to a region repaired with bone cement. One example includes adjacent vertebral body fractures in vertebroplasty procedures.

    摘要翻译： 示出了包括单体和与单体完全混溶的非反应性物质的骨水泥。 所得到的固化骨水泥具有所需的性质，如材料刚度的改性。 可以调整这种刚性的改进性能以匹配骨性质并减少与用骨水泥修复的区域相邻的骨折的发生。 一个例子包括椎体成形术中相邻的椎体骨折。