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公开(公告)号：US09216188B2
公开(公告)日：2015-12-22
申请号：US12553800
申请日：2009-09-03
IPC分类号： A61K9/00 , A61K31/00 , A61K31/7052 , A61L27/26 , A61L27/38 , A61L27/52 , C08J3/075 , C08J3/24
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译： 本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。 将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。 特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。 本发明还提供了制备和使用本发明水凝胶的方法。
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公开(公告)号：US20100055184A1
公开(公告)日：2010-03-04
申请号：US12553800
申请日：2009-09-03
IPC分类号： A61K9/00 , C07C43/11 , C07C31/18 , C07K14/00 , C08B37/00 , C08B37/02 , C08B37/04 , C07K14/78 , A61P19/04 , C08B15/06 , A61K35/00 , A61K35/12 , A61K38/02 , A61K38/16 , A61K31/7052
CPC分类号： A61L27/26 , A61K31/00 , A61K31/7052 , A61L27/38 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08J3/075 , C08J3/246 , C08J2305/08 , C08J2371/02 , C08L71/02
摘要： The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrogels or compositions thereof are injected into the superficial lamina propria or phonatory epithelium to restore the phonatory mucosa of the vocal cords, thereby restoring a patient's voice. In particular, it has been discovered that hydrogels with an elastic shear modulus of approximately 25 Pa are useful in restoring the pliability of the phonatory mucosa. The invention also provides methods of preparing and using the inventive hydrogels.
摘要翻译： 本发明提供水凝胶及其组合物，用于声带修复或增强，以及其它软组织修复或增强（例如，膀胱颈增大，皮肤填充剂，乳房植入物，椎间盘，肌肉质量）。 将水凝胶或其组合物注射到表层固有层或声音上皮中以恢复声带的声音粘膜，从而恢复患者的声音。 特别地，已经发现弹性剪切模量为约25Pa的水凝胶可用于恢复发音粘膜的柔韧性。 本发明还提供了制备和使用本发明水凝胶的方法。
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