-
公开(公告)号：US20170112125A1
公开(公告)日：2017-04-27
申请号：US15282938
申请日：2016-09-30
IPC分类号： A01N25/04 , A01N25/22 , A01N43/90 , A01N43/653 , A23K20/10 , A01N47/38 , A01N43/40 , A01N43/54 , A01N25/30 , A23L33/10 , A01N53/00 , A01N47/02
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
-
公开(公告)号：US20130196852A1
公开(公告)日：2013-08-01
申请号：US13877864
申请日：2011-10-04
IPC分类号： A01N25/04
CPC分类号： A01N25/04 , A01N25/22 , A01N25/30 , A01N43/40 , A01N43/54 , A01N43/653 , A01N43/90 , A01N47/02 , A01N47/38 , A01N53/00 , A23K20/10 , A23L33/10 , A23V2002/00 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5192
摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
摘要翻译： 本发明提供一种制备包含至少一种活性剂和至少一种固体载体材料的改进组合物的方法，其中活性剂以纳米分散形式分散在载体材料中，该方法包括以下步骤：（a） 形成包含活性剂，载体材料，稳定剂，活性剂和稳定剂的第一溶剂和用于载体材料的第二溶剂的液体混合物，和（b）干燥所述液体混合物以除去第一 和第二溶剂，以在载体材料中获得活性剂与稳定剂的基本上无溶剂的纳米分散体，其中所述稳定剂能够在干燥期间稳定液体混合物中的活性剂，并且在所得的液体纳米 - 改进组合物的分散。
-
公开(公告)号：US20110217340A1
公开(公告)日：2011-09-08
申请号：US13059462
申请日：2009-07-24
CPC分类号： A61K9/1694 , A61K9/1623 , A61K9/1635 , B01J2/04
摘要： A process for the production of a soluble composition comprising a water-insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800 nm, preferably below 500 nm and more preferably below 200 nm. The invention also relates to an analogous “reverse” process in which the active is water soluble and the carrier is oil soluble.
摘要翻译： 一种用于生产包含水不溶性活性物质的可溶性组合物的方法，其包括以下步骤：a）提供液体混合物，其包含：i）溶解的水不溶性活性物质，ii）溶解的水溶性载体，iii） 用于活性物质和载体中的每一种的溶剂，以及b）将混合物喷雾造粒以除去溶剂或每种溶剂，并获得载体中不溶于水的活性物质的基本上无溶剂的纳米分散体，所述水不溶性 活性纳米颗粒的尺寸范围为999〜20nm; 或者步骤：a）提供基本上无溶剂的粉末，其包含分散在水溶性载体中的不溶于水的活性物质，所述水不溶性活性物质的尺寸范围为999-20nm， b）将粉末喷雾造粒以获得更大和更致密的颗粒。 本发明还涉及粒径在20微米至10毫米范围内的无溶剂颗粒状产品，其中堆积密度大于0.4克/厘米3，包含一种水溶性载体材料，载体材料已分散在其中 其中在加入水时，载体溶解以形成具有低于800nm，优选低于500nm，更优选低于200nm的峰（z-平均）粒度的活性物质的水分散体。 本发明还涉及类似的“反向”方法，其中活性物质是水溶性的并且载体是油溶性的。
-
公开(公告)号：US20070298239A1
公开(公告)日：2007-12-27
申请号：US10587731
申请日：2005-01-28
申请人： Andrew Cooper , David Duncalf , Alison Foster , Steven Rannard , Haifei Zhang
发明人： Andrew Cooper , David Duncalf , Alison Foster , Steven Rannard , Haifei Zhang
CPC分类号： C11D3/3769 , C11D3/222 , C11D3/3761 , C11D11/0082 , C11D17/0034 , Y10T428/249953 , Y10T428/249954 , Y10T428/2982
摘要： Water dispersible or water soluble porous bodies comprising a three dimensional open-cell lattice containing 10 to 95% by weight of a polymeric material which is soluble in water, and, less than 5% by weight of a surfactant, said porous bodies having an intrusion volume as measured by mercury porosimetry (as hereinafter described) of at least about 3 ml/g, and, with the proviso that said porous bodies are not spherical beads having an average bead diameter of 0.2 to 5 mm. And a method for making the same comprising the steps of: providing an intimate mixture of the polymeric material and any surfactant in a liquid medium: providing a fluid freezing medium at a temperature effective for rapidly freezing the liquid medium; cooling the liquid medium with the fluid freezing medium at a temperature below the freezing point of the liquid medium for a period effective to rapidly freeze the liquid medium; and freeze-drying the frozen liquid medium to form the porous bodies by removal of the liquid medium by sublimation.
摘要翻译： 水分散性或水溶性多孔体，其包含含有10至95重量％的可溶于水的聚合物材料和小于5重量％表面活性剂的三维开孔格子，所述多孔体具有入侵 通过水银孔隙率法（如下所述）测量的至少约3ml / g的体积，条件是所述多孔体不是具有0.2至5mm平均珠粒直径的球形珠粒。 和制备该方法的方法包括以下步骤：在液体介质中提供聚合物材料和任何表面活性剂的紧密混合物：在有效快速冷冻液体介质的温度下提供流体冷冻介质; 在低于液体介质凝固点的温度下，用流体冷冻介质冷却液体介质，持续有效使液体介质快速冷冻的时间; 并通过升华除去液体介质来冷冻冷冻的液体介质以形成多孔体。
-
公开(公告)号：US20050063919A1
公开(公告)日：2005-03-24
申请号：US10665711
申请日：2003-09-19
申请人： Han Chang , Dominique Charmot , David Duncalf , Oleg Kolosov , Victor Nava-Salgado , Son Nguyen , Miroslav Petro , Steven Rannard
发明人： Han Chang , Dominique Charmot , David Duncalf , Oleg Kolosov , Victor Nava-Salgado , Son Nguyen , Miroslav Petro , Steven Rannard
CPC分类号： A61Q11/00 , A61K8/8152 , A61K8/8158 , A61K8/8164
摘要： Oral care composition comprising a polymer obtainable by copolymerising a mixture of comonomers, from 5 to 95 mol % of the mixture of comonomers is constituted by a comonomer having the formula (I): H2C═C(R)-L-(CH2)n-Y (I)in which R is hydrogen or a methyl group, L is a divalent organic linking group incorporating a benzyl or a carboxyl functionality, n is an integer of from 1 to 4 and Y is an amine, quaternized amine or quaternary ammonium group; and in which the balance of the mixture of comonomers is constituted by neutral and/or anionic comonomers; said composition being in the form of any one of a toothpaste, gel, foam, chewing gum, deformable strip or mouthwash and being suitable for use in the oral cavity.
摘要翻译： 含有共聚单体混合物（5〜95摩尔％的共聚单体混合物）的口腔护理组合物由具有式（I）的共聚单体构成：H2C = C（R）-L-（CH2）nY （I）其中R是氢或甲基，L是包含苄基或羧基官能团的二价有机连接基团，n是1至4的整数，Y是胺，季铵化胺或季铵基团; 其中共聚单体混合物的平衡由中性和/或阴离子共聚单体构成; 所述组合物为牙膏，凝胶，泡沫，口香糖，可变形条或漱口剂中任一种的形式，并且适合用于口腔。
-
公开(公告)号：US20050063920A1
公开(公告)日：2005-03-24
申请号：US10666487
申请日：2003-09-19
申请人： Han Chang , Dominique Charmot , David Duncalf , Oleg Kolosov , Victor Nava-Salgado , Son Nguyen , Miroslav Petro , Steven Rannard
发明人： Han Chang , Dominique Charmot , David Duncalf , Oleg Kolosov , Victor Nava-Salgado , Son Nguyen , Miroslav Petro , Steven Rannard
CPC分类号： A61K8/8158 , A61K8/86 , A61K2800/5426 , A61Q11/00
摘要： Oral care composition comprising a cationic polymer obtainable by copolymerising a mixture of comonomers, said mixture comprising (ar-vinylbenzyl) trimethylammonium chloride, 2-acrylamido-2-methyl-1-propanesulfonic acid and polyethyleneglycol methylethermethacrylate, said composition being in the form of any one of a toothpaste, gel, foam, chewing gum, deformable strip or mouthwash and being suitable for use in the oral cavity.
摘要翻译： 包含阳离子聚合物的口腔护理组合物，所述阳离子聚合物可通过使共聚单体的混合物共聚获得，所述混合物包含（芳基苄基）三甲基氯化铵，2-丙烯酰胺基-2-甲基-1-丙磺酸和聚乙二醇甲基醚甲基丙烯酸酯，所述组合物为任何形式 牙膏，凝胶，泡沫，口香糖，可变形条或漱口水之一，适用于口腔。
-
公开(公告)号：US06664350B1
公开(公告)日：2003-12-16
申请号：US09555145
申请日：2000-08-14
申请人： David M. Haddleton , Arnaud Radigue , Dax Kukulj , David Duncalf
发明人： David M. Haddleton , Arnaud Radigue , Dax Kukulj , David Duncalf
IPC分类号： C08F402
CPC分类号： C08F4/02 , C08F4/26 , Y10S526/904
摘要： The invention relates to supported ligands and catalysts for use in the polymerization of olefinically unsaturated monomers such as vinylic monomers, comprising the use of a compound attached to support, the compound being capable of complexing with a transitional metal. Preferably the compound capable of complexing with a transition metal is a diimine such as a 1,4-diaza-1,3-butadiene, a 2-pyridinecarbaldehyde imine, an oxazolidone or a quinoline carbaldeyde. Preferably the catalysts are used in conjunction with an initiator comprising a homolytically cleavable bond with a halogen atom. The application also discloses processes for attaching ligands to supports, and processes for using the catalysts disclosed in the application.
摘要翻译： 本发明涉及用于聚合烯属不饱和单体如乙烯基单体的载体配体和催化剂，其包括使用连接于载体上的化合物，该化合物能够与过渡金属络合。 优选地，能够与过渡金属络合的化合物是二亚胺，例如1,4-二氮杂-1,3-丁二烯，2-吡啶甲醛亚胺，恶唑烷酮或喹啉碳链。 优选地，催化剂与包含与卤素原子的均可切割键的引发剂结合使用。 本申请还公开了将配体连接到载体上的方法，以及使用本申请中公开的催化剂的方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.029 秒)
