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    NANODISPERSE COMPOSITIONS
    1.
    发明申请
    NANODISPERSE COMPOSITIONS 审中-公开
    纳米复合材料

    公开(公告)号：US20110217340A1

    公开(公告)日：2011-09-08

    申请号：US13059462

    申请日：2009-07-24

    申请人： Doris Angus ,  Alison Jayne Foster ,  David Duncalf ,  Steven Paul Rannard ,  Dong Wang

    发明人： Doris Angus ,  Alison Jayne Foster ,  David Duncalf ,  Steven Paul Rannard ,  Dong Wang

    IPC分类号： A61K9/14 ,  A61K38/43 ,  A61K31/122 ,  C08K5/23 ,  C08K3/16 ,  B82Y30/00

    CPC分类号： A61K9/1694 ,  A61K9/1623 ,  A61K9/1635 ,  B01J2/04

    摘要： A process for the production of a soluble composition comprising a water-insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800 nm, preferably below 500 nm and more preferably below 200 nm. The invention also relates to an analogous “reverse” process in which the active is water soluble and the carrier is oil soluble.

    摘要翻译： 一种用于生产包含水不溶性活性物质的可溶性组合物的方法，其包括以下步骤：a）提供液体混合物，其包含：i）溶解的水不溶性活性物质，ii）溶解的水溶性载体，iii） 用于活性物质和载体中的每一种的溶剂，以及b）将混合物喷雾造粒以除去溶剂或每种溶剂，并获得载体中不溶于水的活性物质的基本上无溶剂的纳米分散体，所述水不溶性 活性纳米颗粒的尺寸范围为999〜20nm; 或者步骤：a）提供基本上无溶剂的粉末，其包含分散在水溶性载体中的不溶于水的活性物质，所述水不溶性活性物质的尺寸范围为999-20nm， b）将粉末喷雾造粒以获得更大和更致密的颗粒。 本发明还涉及粒径在20微米至10毫米范围内的无溶剂颗粒状产品，其中堆积密度大于0.4克/厘米3，包含一种水溶性载体材料，载体材料已分散在其中 其中在加入水时，载体溶解以形成具有低于800nm，优选低于500nm，更优选低于200nm的峰（z-平均）粒度的活性物质的水分散体。 本发明还涉及类似的“反向”方法，其中活性物质是水溶性的并且载体是油溶性的。

    PROCESSES FOR PREPARING IMPROVED COMPOSITIONS
    5.
    发明申请
    PROCESSES FOR PREPARING IMPROVED COMPOSITIONS 审中-公开
    制备改进成分的方法

    公开(公告)号：US20130196852A1

    公开(公告)日：2013-08-01

    申请号：US13877864

    申请日：2011-10-04

    申请人： Steven Paul Rannard ,  David Duncalf ,  Alison Jayne Foster ,  James Long ,  Dong Wang

    发明人： Steven Paul Rannard ,  David Duncalf ,  Alison Jayne Foster ,  James Long ,  Dong Wang

    IPC分类号： A01N25/04

    CPC分类号： A01N25/04 ,  A01N25/22 ,  A01N25/30 ,  A01N43/40 ,  A01N43/54 ,  A01N43/653 ,  A01N43/90 ,  A01N47/02 ,  A01N47/38 ,  A01N53/00 ,  A23K20/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/5138 ,  A61K9/5146 ,  A61K9/5161 ,  A61K9/5192

    摘要： The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.

    摘要翻译： 本发明提供一种制备包含至少一种活性剂和至少一种固体载体材料的改进组合物的方法，其中活性剂以纳米分散形式分散在载体材料中，该方法包括以下步骤：（a） 形成包含活性剂，载体材料，稳定剂，活性剂和稳定剂的第一溶剂和用于载体材料的第二溶剂的液体混合物，和（b）干燥所述液体混合物以除去第一 和第二溶剂，以在载体材料中获得活性剂与稳定剂的基本上无溶剂的纳米分散体，其中所述稳定剂能够在干燥期间稳定液体混合物中的活性剂，并且在所得的液体纳米 - 改进组合物的分散。