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    Artificial Intervertebral Joint Permitting Translational and Rotational Motion
    1.
    发明申请
    Artificial Intervertebral Joint Permitting Translational and Rotational Motion 有权
    人工椎间关节允许平移和旋转运动

    公开(公告)号：US20100049323A1

    公开(公告)日：2010-02-25

    申请号：US12612916

    申请日：2009-11-05

    申请人： Steven S. Gill ,  Colin Walker ,  James Van Hoeck ,  Larry Gause

    发明人： Steven S. Gill ,  Colin Walker ,  James Van Hoeck ,  Larry Gause

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4611 ,  A61B17/86 ,  A61F2/4425 ,  A61F2002/30369 ,  A61F2002/30578 ,  A61F2002/30649 ,  A61F2002/30654 ,  A61F2002/30787 ,  A61F2002/30794 ,  A61F2002/30828 ,  A61F2220/0033

    摘要： An intervertebral joint prosthesis having a ball component (22) for engagement with a first vertebra (26) and a trough component (24) for engagement with a second vertebra (27) adjacent to the first vertebra is disclosed. The trough component (24) includes a generally concave surface (50) having a substantially flat portion (52). When the ball component (22) and the trough component (24) are engaged to their respective vertebrae, the ball component (72) and the trough component (24) engage each other, permitting rotation and translation of the vertebrae with respect to each other. Both components include a flange (34, 56) for engaging a vertebra. The invention also contemplates a method for and a tool for use in implanting a two-piece intervertebral joint prosthesis.

    摘要翻译： 公开了一种椎间关节假体，其具有用于与第一椎骨（26）接合的球部件（22）和用于与邻近第一椎骨的第二椎骨（27）接合的槽部件（24）。 槽组件（24）包括具有基本平坦部分（52）的大体上凹的表面（50）。 当球部件（22）和槽部件（24）与其相应的椎骨接合时，球部件（72）和槽部件（24）彼此接合，允许椎骨相对于彼此旋转和平移 。 两个部件包括用于接合椎骨的凸缘（34,56）。 本发明还考虑了用于植入两件式椎间关节假体的方法和工具。

    Artificial intervertebral joint permitting translational and rotational motion
    2.
    发明授权
    Artificial intervertebral joint permitting translational and rotational motion 有权
    人工椎间关节允许平移和旋转运动

    公开(公告)号：US06540785B1

    公开(公告)日：2003-04-01

    申请号：US09534767

    申请日：2000-03-24

    申请人： Steven S. Gill ,  Colin Walker ,  James van Hoeck ,  Larry Gause

    发明人： Steven S. Gill ,  Colin Walker ,  James van Hoeck ,  Larry Gause

    IPC分类号： A61F244

    CPC分类号： A61F2/4611 ,  A61B17/86 ,  A61F2/4425 ,  A61F2002/30369 ,  A61F2002/30578 ,  A61F2002/30649 ,  A61F2002/30654 ,  A61F2002/30787 ,  A61F2002/30794 ,  A61F2002/30828 ,  A61F2220/0033

    摘要： An intervertebral joint prosthesis having a ball component (22) for engagement with a first vertebra (26) and a trough component (24) for engagement with a second vertebra (27) adjacent to the first vertebra is disclosed. The trough component (24) includes a generally concave surface (50) having a substantially flat portion (52). When the ball component (22) and the trough component (24) are engaged to their respective vertebrae, the ball component (72) and the trough component (24) engage each other, permitting rotation and translation of the vertebrae with respect to each other. Both components include a flange (34,56) for engaging a vertebra. The invention also contemplates a method for and a tool for use in implanting a two-piece intervertebral joint prosthesis.

    摘要翻译： 公开了一种椎间关节假体，其具有用于与第一椎骨（26）接合的球部件（22）和用于与邻近第一椎骨的第二椎骨（27）接合的槽部件（24）。 槽组件（24）包括具有基本平坦部分（52）的大体上凹的表面（50）。 当球部件（22）和槽部件（24）与其相应的椎骨接合时，球部件（72）和槽部件（24）彼此接合，允许椎骨相对于彼此旋转和平移 。 两个部件包括用于接合椎骨的凸缘（34,56）。 本发明还考虑了用于植入两件式椎间关节假体的方法和工具。

    Artificial intervertebral joint permitting translational and rotational motion
    3.
    发明授权
    Artificial intervertebral joint permitting translational and rotational motion 有权
    人工椎间关节允许平移和旋转运动

    公开(公告)号：US08206399B2

    公开(公告)日：2012-06-26

    申请号：US10404515

    申请日：2003-04-01

    申请人： Steven S. Gill ,  Colin Walker ,  James van Hoeck ,  Larry Gause

    发明人： Steven S. Gill ,  Colin Walker ,  James van Hoeck ,  Larry Gause

    IPC分类号： A61B17/70 ,  A61F2/44

    CPC分类号： A61F2/4611 ,  A61B17/86 ,  A61F2/4425 ,  A61F2002/30369 ,  A61F2002/30578 ,  A61F2002/30649 ,  A61F2002/30654 ,  A61F2002/30787 ,  A61F2002/30794 ,  A61F2002/30828 ,  A61F2220/0033

    摘要： An intervertebral joint prosthesis having a ball component (22) for engagement with a first vertebra (26) and a trough component (24) for engagement with a second vertebra (27) adjacent to the first vertebra is disclosed. The trough component (24) includes a generally concave surface (50) having a substantially flat portion (52). When the ball component (22) and the trough component (24) are engaged to their respective vertebrae, the ball component (72) and the trough component (24) engage each other, permitting rotation and translation of the vertebrae with respect to each other. Both components include a flange (34,56) for engaging a vertebra. The invention also contemplates a method for and a tool for use in implanting a two-piece intervertebral joint prosthesis.

    摘要翻译： 公开了一种椎间关节假体，其具有用于与第一椎骨（26）接合的球部件（22）和用于与邻近第一椎骨的第二椎骨（27）接合的槽部件（24）。 槽组件（24）包括具有基本平坦部分（52）的大体上凹的表面（50）。 当球部件（22）和槽部件（24）与其相应的椎骨接合时，球部件（72）和槽部件（24）彼此接合，允许椎骨相对于彼此旋转和平移 。 两个部件包括用于接合椎骨的凸缘（34,56）。 本发明还考虑了用于植入两件式椎间关节假体的方法和工具。

    Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
    5.
    发明授权
    Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen 有权
    通过对对角增强输注胶质细胞系衍生的神经营养因子到壳核来治疗人类帕金森病的方法

    公开(公告)号：US08946151B2

    公开(公告)日：2015-02-03

    申请号：US10963986

    申请日：2004-10-13

    申请人： Steven S. Gill ,  Don M. Gash ,  Greg A. Gerhardt

    发明人： Steven S. Gill ,  Don M. Gash ,  Greg A. Gerhardt

    IPC分类号： A61K38/18

    CPC分类号： A61K38/185

    摘要： A method of treating Parkinson's disease in humans is disclosed, wherein glial cell-line derive neurotrophic factor (GDNF) is chronically administered directly to one or both putamen of a human in need of treatment thereof via convection-enhanced infusion using at least one implantable pump and at least one catheter. In one aspect of the present invention the GDNF is infused directly into one or both putamen through one or more indwelling intraparenchymal multiport brain catheters connected to one or more implantable pumps wherein the flow rate is pulsed.

    摘要翻译： 公开了一种治疗人类帕金森病的方法，其中胶质细胞系衍生的神经营养因子（GDNF）通过使用至少一个可植入泵直接经由对流增强输注而被长期地直接施用于需要治疗的人的一个或两个壳， 和至少一个导管。 在本发明的一个方面，GDNF通过连接到一个或多个可植入泵的一个或多个留置的实质内多孔口脑导管直接注入一个或两个壳核，其中流速是脉冲的。

    Surgical appliance for forming an opening through the skin
    6.
    发明授权
    Surgical appliance for forming an opening through the skin 失效
    用于形成通过皮肤的开口的外科用具

    公开(公告)号：US4716901A

    公开(公告)日：1988-01-05

    申请号：US779810

    申请日：1985-09-25

    申请人： Joseph F. Jackson ,  Steven S. Gill

    发明人： Joseph F. Jackson ,  Steven S. Gill

    IPC分类号： A61D1/00 ,  A61B1/32 ,  A61B17/34 ,  A61M29/00

    CPC分类号： A61B17/3439

    摘要： The invention relates to a surgical appliance for forming an opening through the skin of a patient and for distending the opening so formed. The appliance takes the form of a trocar which may comprise two separate components or two component portions formed by openings in a tube extending partially along the tube from the distal end. In either case, the components or component portions are preloaded towards a closed condition, but can be expanded into an open condition, for example by forcing a tubular expander into the trocar from the proximal end. The preloading of the trocar may be by a resilient sleeve surrounding the components or by a "set" introduced into the material forming the components. A cutting edge may be formed across substantially the full width of the distal end of the trocar and it is preferred that in the open condition, there is a no significant increase in the cross-section of the trocar towards the distal end.

    摘要翻译： 本发明涉及一种用于形成穿过患者皮肤的开口并用于使形成的开口膨胀的外科器具。 该器具采用套管针的形式，该套管针可以包括两个分开的部件或两个部件部分，该两部分部分或两部分部分由管子中的开口形成，所述管部分地沿着管从远端延伸。 在任一种情况下，组件或组件部分被预加载到关闭状态，但是可以扩展到打开状态，例如通过从近端迫使管状膨胀器进入套管针。 套管针的预加载可以通过围绕组件的弹性套筒或通过引入形成组件的材料的“套件”来实现。 可以在套管针的远端的基本上整个宽度上形成切割边缘，并且优选地，在打开状态下，套管针朝向远端的横截面没有显着增加。

    Therapy control based on a patient movement state
    7.
    发明授权
    Therapy control based on a patient movement state 有权
    基于患者运动状态的治疗控制

    公开(公告)号：US08554325B2

    公开(公告)日：2013-10-08

    申请号：US13345397

    申请日：2012-01-06

    申请人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    发明人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    IPC分类号： A61N1/18

    CPC分类号： A61B5/04014 ,  A61B5/0006 ,  A61B5/4082 ,  A61B5/6814 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36067 ,  A61N1/36082

    摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.

    摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

    THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE
    9.
    发明申请
    THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
    基于患者运动状态的治疗控制

    公开(公告)号：US20090099627A1

    公开(公告)日：2009-04-16

    申请号：US12237799

    申请日：2008-09-25

    申请人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    发明人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

    IPC分类号： A61N1/36 ,  A61B5/0476 ,  A61M37/00

    CPC分类号： A61B5/04014 ,  A61B5/0006 ,  A61B5/4082 ,  A61B5/6814 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36067 ,  A61N1/36082

    摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.

    摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

    Expansible cannula
    10.
    发明授权
    Expansible cannula 失效
    可膨胀插管

    公开(公告)号：US4899729A

    公开(公告)日：1990-02-13

    申请号：US204165

    申请日：1988-08-03

    申请人： Steven S. Gill ,  Joseph F. Jackson

    发明人： Steven S. Gill ,  Joseph F. Jackson

    IPC分类号： A61F2/82 ,  A61B17/34 ,  A61M29/00

    CPC分类号： A61M29/02 ,  A61B17/3439

    摘要： The invention relates to a surgical cannula for introducing instruments, scopes or tubing into body cavities or organs. The cannula comprises a conical tubular stem which is formed of thin sheet material, such as beryllium copper, the sheet material being coiled or partially coiled so that if is capable of opening up from a closed condition by reducing the cone angle, thereby increasing the diameter of the stem at the distal end.In the preferred arrangement, the proximal end of the stem is clamped between two tubular elements fitted one inside the other.The invention also includes the combination of the expansible cannula and a guide rod adapted to pass through the stem and bored throughout its length to receive a guide wire. The guide rod may have a slightly enlarged distal end and the arrangement be such that passage of the enlarged distal end through the distal end of the stem causes a slight opening out of the distal end to allow passage of the enlargement.When a blunt instrument such as a nephroscope is forced through the bore of the stem from the relatively large proximal end, the stem will expand by uncoiling until the stem provides a substantially parallel-sided bore through which the blunt instrument can pass.According to a second aspect of the invention an expansible cannular has a stem formed by a plurality of thin sheet material leaves each of arcuate cross-section and overlapped so that together they form a tube which can be increased in diameter by reducing the overlap between the leaves.

    摘要翻译： 本发明涉及用于将仪器，示波器或管道引入体腔或器官的手术插管。 套管包括由诸如铍铜的薄片材料形成的锥形管状杆，片材被卷绕或部分盘绕，使得如果能够通过减小锥角从闭合状态打开，从而增加直径 的茎在远端。 在优选的布置中，杆的近端夹在两个装在另一个内的管状元件之间。 本发明还包括可膨胀套管和适于穿过杆的导杆的组合，并且在整个长度上钻孔以接纳导丝。 导杆可以具有稍微扩大的远端，并且该布置使得扩大的远端通过杆的远端的通道使得从远端稍微打开以允许放大通过。 当钝器例如肾镜被迫从相对较大的近端穿过杆的孔时，杆将通过开卷而膨胀，直到杆提供基本上平行的双侧孔，钝器通过该孔可以通过。 根据本发明的第二方面，可膨胀的管状物具有由多个薄片材料叶片形成的茎，每个薄片材料叶片具有弓形横截面并且重叠，使得它们一起形成管，其可以通过减小 树叶。