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    SYSTEMS AND DEVICES FOR MIXING SUBSTANCES AND METHODS OF MAKING SAME
    3.
    发明申请
    SYSTEMS AND DEVICES FOR MIXING SUBSTANCES AND METHODS OF MAKING SAME 有权
    用于混合物质的系统和装置及其制备方法

    公开(公告)号：US20090323466A1

    公开(公告)日：2009-12-31

    申请号：US12297821

    申请日：2007-04-21

    申请人： Steven Vanhamel ,  Jean-Pascal Zambaux ,  Tom Claes

    发明人： Steven Vanhamel ,  Jean-Pascal Zambaux ,  Tom Claes

    IPC分类号： B01F13/00

    CPC分类号： B01F15/00831 ,  B01F7/001 ,  B01F7/00975 ,  B01F11/04 ,  B01F15/0085 ,  B01F15/00974 ,  B01F15/065 ,  B01L3/505 ,  C12M23/26 ,  C12M23/28

    摘要： A mixing apparatus including a kinetic energy source, a mixing tank, a pivot guide, and transfer shaft is used to drive a mixing paddle through a circular path within a tank without substantial shaft rotation. Sleeved and sleeveless mixing paddles are provided in combination with sealable mixing tanks. A volumetric compensation system responsive to tank wall deflection is used to maintain the internal volume of a mixing tank within predetermined limits. One mixing apparatus includes multiple mixing shafts and paddles coupled to at least one kinetic energy source. Methods for fabricating sleeved paddle-containing mixing apparatuses are further provided.

    摘要翻译： 使用包括动能源，混合罐，枢转引导件和输送轴的混合设备来驱动混合桨通过罐内的圆形路径而没有实质的轴旋转。 与可密封的混合罐组合提供袖子和无袖混合桨。 使用响应于罐壁偏转的体积补偿系统来将混合罐的内部容积保持在预定的限度内。 一个混合装置包括耦合到至少一个动能源的多个混合轴和桨叶。 还提供了用于制造带套筒式混合搅拌设备的方法。

    Bioreactor probe connection system
    4.
    发明授权
    Bioreactor probe connection system 有权
    生物反应器探头连接系统

    公开(公告)号：US08568657B2

    公开(公告)日：2013-10-29

    申请号：US12664398

    申请日：2008-06-11

    申请人： Christophe Braet ,  Tom Claes ,  Steven Vanhamel ,  Nicolas Havelange

    发明人： Christophe Braet ,  Tom Claes ,  Steven Vanhamel ,  Nicolas Havelange

    IPC分类号： A61L2/00 ,  A61L2/18 ,  A61L9/00 ,  A61L2/08 ,  B01J19/00

    CPC分类号： B01F11/04 ,  B01F3/04262 ,  B01F2003/04319 ,  B01F2003/04361 ,  C12M23/00 ,  C12M23/14 ,  C12M37/04 ,  C12M41/00

    摘要： A system providing a sterile connection between a sensor probe and a fluid processing apparatus (e.g., a bioreactor) includes a first probe receiving element mountable to the fluid processing apparatus and a second probe receiving element having a gas-permeable contaminant barrier material and coupleable to the first probe receiving element. A sensor probe may be mounted to the second probe receiving element, with the combination being sterilized with a sterilant gas such as steam. Following such sterilization, connection between the first and second probe receiving elements is made through matable sterile couplings, and the probe is insertable through the coupled receiving elements to a position in fluid contact with the interior of the fluid processing apparatus.

    摘要翻译： 在传感器探针和流体处理装置（例如，生物反应器）之间提供无菌连接的系统包括可安装到流体处理装置的第一探针接收元件和具有气体可渗透的污染物阻挡材料的第二探针接收元件， 第一探头接收元件。 传感器探针可以安装到第二探针接收元件上，其中组合用诸如蒸汽的灭菌气体灭菌。 在这种消毒之后，第一和第二探针接收元件之间的连接是通过可配置的无菌联接件制成的，并且探头可通过联接的接收元件插入到与流体处理装置的内部流体接触的位置。

    BIOREACTOR PROBE CONNECTION SYSTEM
    5.
    发明申请
    BIOREACTOR PROBE CONNECTION SYSTEM 有权
    生物探测器探头连接系统

    公开(公告)号：US20100255526A1

    公开(公告)日：2010-10-07

    申请号：US12664398

    申请日：2008-06-11

    申请人： Christophe Braet ,  Tom Claes ,  Steven Vanhamel ,  Nicolas Havelange

    发明人： Christophe Braet ,  Tom Claes ,  Steven Vanhamel ,  Nicolas Havelange

    IPC分类号： C12Q1/02 ,  C12M1/00

    CPC分类号： B01F11/04 ,  B01F3/04262 ,  B01F2003/04319 ,  B01F2003/04361 ,  C12M23/00 ,  C12M23/14 ,  C12M37/04 ,  C12M41/00

    摘要： A system providing a sterile connection between a sensor probe and a fluid processing apparatus (e.g., a bioreactor) includes a first probe receiving element mountable to the fluid processing apparatus and a second probe receiving element having a gas-permeable contaminant barrier material and coupleable to the first probe receiving element. A sensor probe may be mounted to the second probe receiving element, with the combination being sterilized with a sterilant gas such as steam. Following such sterilization, connection between the first and second probe receiving elements is made through matable sterile couplings, and the probe is insertable through the coupled receiving elements to a position in fluid contact with the interior of the fluid processing apparatus.

    摘要翻译： 在传感器探针和流体处理装置（例如，生物反应器）之间提供无菌连接的系统包括可安装到流体处理装置的第一探针接收元件和具有气体可渗透的污染物阻挡材料的第二探针接收元件， 第一探头接收元件。 传感器探针可以安装到第二探针接收元件上，其中组合用诸如蒸汽的灭菌气体灭菌。 在这种消毒之后，第一和第二探针接收元件之间的连接是通过可配置的无菌联接件制成的，并且探头可通过联接的接收元件插入到与流体处理装置的内部流体接触的位置。

    Methods and systems for sensing
    6.
    发明授权
    Methods and systems for sensing 有权
    检测方法和系统

    公开(公告)号：US09139786B2

    公开(公告)日：2015-09-22

    申请号：US13452180

    申请日：2012-04-20

    申请人： Peter Bienstman ,  Tom Claes ,  Katrien De Vos ,  Jan-Willem Hoste ,  Wim Bogaerts

    发明人： Peter Bienstman ,  Tom Claes ,  Katrien De Vos ,  Jan-Willem Hoste ,  Wim Bogaerts

    IPC分类号： G01B5/02 ,  C10J3/46 ,  C10L3/08 ,  C10L3/10

    CPC分类号： C10J3/463 ,  C10J2300/093 ,  C10J2300/0973 ,  C10J2300/0986 ,  C10J2300/1807 ,  C10J2300/1838 ,  C10L3/08 ,  C10L3/101 ,  Y02P20/52

    摘要： A sensing device for sensing a substance includes a photonics integrated circuit having a resonator element that supports two different radiation modes, e.g. radiation modes of different polarisation, at a predetermined resonance wavelength. The resonator element is configured to convert a phase change or amplitude change experienced by the two different radiation modes upon formation of a layer of receptor molecules onto a sensing surface of the device into a resonance wavelength shift for the two different radiation modes. The sensing device also includes a detection unit arranged to detect the resonance wavelength shift for the two different radiation modes. The detection unit includes a processor that is configured to derive from the detected resonance wavelength shifts for the two different radiation modes, a layer thickness and refractive index of the layer of receptor molecules.

    摘要翻译： 用于感测物质的感测装置包括具有支撑两种不同辐射模式的谐振器元件的光子学集成电路，例如， 在预定的共振波长处的不同偏振的辐射模式。 所述谐振器元件被配置为在将所述器件的感测表面上形成受体分子层到所述两种不同辐射模式的谐振波长位移时，将由所述两种不同辐射模式经历的相变或幅度变化转换成谐振波长位移。 感测装置还包括检测单元，其被布置成检测两种不同辐射模式的谐振波长偏移。 检测单元包括处理器，其被配置为从两个不同辐射模式的检测到的共振波长偏移中导出受体分子层的层厚度和折射率。

    Vernier photonic sensor data-analysis
    7.
    发明授权
    Vernier photonic sensor data-analysis 有权
    游标光子传感器数据分析

    公开(公告)号：US09068950B2

    公开(公告)日：2015-06-30

    申请号：US13271875

    申请日：2011-10-12

    申请人： Peter Bienstman ,  Tom Claes ,  Wim Bogaerts

    发明人： Peter Bienstman ,  Tom Claes ,  Wim Bogaerts

    IPC分类号： G01N21/41 ,  G01N21/77

    CPC分类号： G01N21/7746 ,  G01N21/41

    摘要： Quantifying a refractive index of a test medium by obtaining spectral data representative for an optical signal being modulated with an optical transfer characteristics of a photonic sensor, the modulation being obtained by combining modulation of a first electromagnetic wave component in an optical filter element with a first periodic transfer spectrum having a first free spectral range and modulation of a second electromagnetic wave component in an optical filter element with a second periodic transfer spectrum having a second free spectral range being different from the first free spectral range. A relative is change induced in the second periodic transfer spectrum by bringing the test medium in proximity with the optical filter element with the second periodic transfer spectrum. The refractive index of the test medium is quantified by determining a wavelength offset of an envelope signal in said spectral data.

    摘要翻译： 通过获得表示用光子传感器的光学传递特性调制的光信号的光谱数据来量化测试介质的折射率，所述调制是通过将光学滤波器元件中的第一电磁波分量的调制与第一 具有第一自由光谱范围的周期性传输光谱和具有第二自由光谱范围与第一自由光谱范围不同的第二周期性传输光谱的滤光器元件中的第二电磁波分量的调制。 相对是通过使测试介质与具有第二周期性传输频谱的滤光器元件接近而在第二周期性传输频谱中引起的变化。 通过确定所述光谱数据中的包络信号的波长偏移来量化测试介质的折射率。