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    Method for effecting the rapid release of a signature chemical from bacterial endospores, and for detection thereof
    1.
    发明申请
    Method for effecting the rapid release of a signature chemical from bacterial endospores, and for detection thereof 有权
    用于快速释放来自细菌内生孢子的签名化学品的方法和用于检测

    公开(公告)号：US20060257891A1

    公开(公告)日：2006-11-16

    申请号：US11355782

    申请日：2006-02-16

    Applicant: Stuart Farquharson ,  Frank Inscore ,  Alan Gift ,  Chetan Shende

    Inventor： Stuart Farquharson ,  Frank Inscore ,  Alan Gift ,  Chetan Shende

    IPC: C12Q1/68

    CPC classification number: C12Q1/04 ,  G01N2333/32 ,  G01N2333/33 ,  Y02A50/451

    Abstract: A weak organic acid is used to effect the release of CaDPA from Bacillus or Clostridium endospores, rapidly and at room temperature, to enable detection and measurement of DPA and thereby the assessment of risk associated with exposure to Bacillus anthracis, Clostridium botulinum, and like spores. The method can be applied to airborne, food-borne, and water-borne spores, as well as to spores collected from surfaces or contained in body fluids, and analysis is advantageously carried out using surface-enhanced Raman spectroscopy.

    Abstract translation: 使用弱有机酸快速和室温下从芽孢杆菌或梭状芽孢杆菌内孢子中释放CaDPA，以便能够检测和测量DPA，从而评估与接触炭疽芽孢杆菌，肉毒梭菌和类似孢子相关的风险 。 该方法可以应用于空气传播，食源性和水性孢子，以及从表面收集的或包含在体液中的孢子，并且有利地使用表面增强拉曼光谱进行分析。

    Apparatus for two-step surface-enhanced raman spectroscopy
    2.
    发明申请
    Apparatus for two-step surface-enhanced raman spectroscopy 审中-公开
    两步表面增强拉曼光谱仪的设备

    公开(公告)号：US20160003747A1

    公开(公告)日：2016-01-07

    申请号：US14756502

    申请日：2015-09-11

    Applicant: Stuart Farquharson ,  Chetan Shende

    Inventor： Stuart Farquharson ,  Chetan Shende

    IPC: G01N21/65 ,  G01N33/543

    CPC classification number: G01N21/658 ,  G01N33/54373 ,  G01N33/58 ,  G01N33/587

    Abstract: A kit of components is used in the detection, identification, analysis, and quantitation, by SERS, of a designated target analyte in a sample, comprising: packaging means normally containing a SER-active device component providing a support structure including a SER-active material, a collection component, a container component containing a liquid reagent comprised of a SER-active material, and a component for introducing the liquid reagent into the SER-active device. At least one of the SER-active materials is functionalized with an agent having the specific capability of binding the designated target analyte, and is accessible for the deposit thereon of liquid analyte samples. The SER-active device is constructed for receiving the liquid reagent and for enabling irradiation and collection of Raman-scattered radiation, by and from a Raman spectrometer, cooperatively generated by SER-active metals of the SER-active materials.

    Abstract translation: SERS在样品中的指定目标分析物的检测，鉴定，分析和定量中使用一组成分，包括：通常包含提供包含SER活性的支持结构的SER活性器件组分的包装装置 材料，收集成分，含有由SER活性物质构成的液体试剂的容器成分，以及将液体试剂引入SER活性器件的成分。 至少一种SER活性材料用具有与指定靶标分析物结合的特异性能的试剂进行官能化，并可用于在其上沉积液体分析物样品。 SER活性器件被构造为用于接收液体试剂并且用于通过由SER活性材料的SER活性金属协同产生的拉曼光谱仪的拉曼散射辐射的照射和收集。

    Method and apparatus for two-step surface-enhanced raman spectroscopy
    3.
    发明授权
    Method and apparatus for two-step surface-enhanced raman spectroscopy 有权
    两步表面增强拉曼光谱法的方法和装置

    公开(公告)号：US09134247B2

    公开(公告)日：2015-09-15

    申请号：US13374225

    申请日：2011-12-16

    Applicant: Atanu Sengupta ,  Frank E. Inscore ,  Chetan Shende ,  Michael J. Donahue ,  Stuart Farquharson

    Inventor： Atanu Sengupta ,  Frank E. Inscore ,  Chetan Shende ,  Michael J. Donahue ,  Stuart Farquharson

    IPC: G01N21/65 ,  G01N33/58

    CPC classification number: G01N21/658 ,  G01N33/54373 ,  G01N33/58 ,  G01N33/587

    Abstract: A SERS method and apparatus employ a sample device having support structure including a first material containing a SER-active metal functionalized with a binding agent having specific capability for binding a designated target analyte. An analyte sample is introduced upon the functionalized SER-active metal; conditions to effect binding of the target analyte to the binding agent are maintained; unbound chemicals, biochemicals, or biologicals are removed; a second SER-active material is introduced to cause it to attach to the bound target analyte; the support structure is irradiated to generate a SER spectrum, with the first and second SER-active materials acting in concert; and the SER spectrum is detected and analyzed to determine the presence and quantity of the target analyte. Alternatively, the second SER-active material may be functionalized with a binding agent, with the procedure being modified accordingly.

    Abstract translation: SERS方法和装置使用具有支撑结构的样品装置，该样品装置包括含有用具有特异性结合指定靶标分析物能力的结合剂官能化的SER-活性金属的第一材料。 将分析物样品引入功能化的SER-活性金属上; 维持目标分析物与结合剂结合的条件; 未结合的化学物质，生物化学物质或生物制品被去除; 引入第二SER活性材料以使其附着于结合的靶分析物; 照射支撑结构以产生SER光谱，其中第一和第二SER活性材料一致; 并检测和分析SER光谱，以确定目标分析物的存在和数量。 或者，第二SER活性材料可以用粘合剂进行官能化，其过程被相应地改变。

    Method for quantitative surface-enhanced raman spectroscopy using a chemical reference
    7.
    发明申请
    Method for quantitative surface-enhanced raman spectroscopy using a chemical reference 审中-公开
    使用化学参考的定量表面增强拉曼光谱法的方法

    公开(公告)号：US20050266583A1

    公开(公告)日：2005-12-01

    申请号：US10854134

    申请日：2004-05-26

    Applicant: Stuart Farquharson ,  Frank Inscore ,  Chetan Shende ,  Alan Gift

    Inventor： Stuart Farquharson ,  Frank Inscore ,  Chetan Shende ,  Alan Gift

    IPC: G01N21/27 ,  G01N21/47 ,  G01N21/62 ,  G01N21/65

    CPC classification number: G01N21/658 ,  G01N21/278

    Abstract: A method for obtaining quantitative surface-enhanced Raman (SER) spectra that corrects for deficiencies of, and variations in, the materials and devices employed, especially the SER-active media utilized, employs a reference chemical, having an effective surface-enhanced Raman factor, of known concentration within the same SER experimental field of view as the analyte chemical being measured. Knowledge of the relative amounts of SER-scattering for the reference chemical and analyte chemical allows calculating the concentration of the latter to a high degree of accuracy and precision.

    Abstract translation: 获得定量表面增强拉曼（SER）光谱的方法，其校正所用材料和装置的缺陷和变化，特别是所用的SER活性介质，采用具有有效表面增强拉曼因子的参考化学品 在与测量的分析物质相同的SER实验视野内具有已知浓度。 了解参考化学品和分析物化学品的SER散射的相对量，可以高精度和精确地计算后者的浓度。

    METHOD AND APPARATUS FOR DETERMINING PROPERTIES OF FUELS
    8.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING PROPERTIES OF FUELS 有权
    用于确定燃料特性的方法和装置

    公开(公告)号：US20100211329A1

    公开(公告)日：2010-08-19

    申请号：US12734091

    申请日：2008-10-10

    Applicant: Stuart Farquharson ,  Wayne W. Smith

    Inventor： Stuart Farquharson ,  Wayne W. Smith

    IPC: G06F19/00

    CPC classification number: G01N21/359 ,  G01N21/3577 ,  G01N21/65 ,  G01N21/84 ,  G01N2021/6421 ,  G01N2021/8411 ,  G01N2201/1293

    Abstract: The method and apparatus are used to determine class, grade and properties of fuel samples, regardless of ambient, instrument, or sample temperature, using mathematical correlations between fuel class, grade and properties and their spectra developed from a database of samples with measured properties and spectra. The ability to measure a fuel sample using the present method and apparatus is useful in identifying unknown fuel samples, determining suitability in equipment, and monitoring and controlling fuel processes, such as blending operations, distillation, and synthesis.

    Abstract translation: 该方法和设备用于确定燃料样品的等级，等级和性能，无论环境，仪器或样品温度如何，使用燃料类别，等级和性质之间的数学相关性以及从具有测量性质的样品数据库开发的光谱，以及 光谱。 使用本方法和装置测量燃料样品的能力可用于识别未知燃料样品，确定设备的适用性，以及监测和控制燃料过程，例如混合操作，蒸馏和合成。

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