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    Protein labeling reagents
    4.
    发明授权
    Protein labeling reagents 失效
    蛋白标记试剂

    公开(公告)号：US5175256A

    公开(公告)日：1992-12-29

    申请号：US590180

    申请日：1990-09-28

    申请人： Sudhakar Kasina ,  Ananthachari Srinivasan ,  James Sanderson ,  Alan R. Fritzberg

    发明人： Sudhakar Kasina ,  Ananthachari Srinivasan ,  James Sanderson ,  Alan R. Fritzberg

    IPC分类号： A61K51/10 ,  C07C319/18 ,  C07C323/52 ,  C07D307/60 ,  C07D339/06 ,  C07D495/04

    CPC分类号： C07D495/04 ,  A61K51/1093 ,  C07C319/18 ,  C07D307/60 ,  C07D339/06 ,  A61K2123/00 ,  Y02P20/55

    摘要： Novel labeling reagents are useful for radiolabeling proteins such as antibodies with radionuclide metals such as .sup.99m Tc, .sup.186 Re, and .sup.188 Re. The reagents are of the following formula: ##STR1## wherein: each X is independently chosen from O, S, NH, or NR.sub.2, wherein R.sub.2 is a protecting group or an electron withdrawing group;R.sub.1 represents a protecting group, wherein each R.sub.1 is a separate protecting group or the two R.sub.1 symbols are taken together to represent a single protecting group; andeach T is independently chosen from hydrogen, lower alkyl groups of from 1 to about 6 carbon atoms, electron withdrawing groups, and lower alkyl groups of from 1 to about 6 carbon atoms substituted with electron withdrawing group(s).

    摘要翻译： 新型标记试剂可用于放射性标记蛋白，如具有放射性核素金属如99mTc，186Re和188Re的抗体。 试剂为下式：其中：各X独立地选自O，S，NH或NR 2，其中R 2为保护基或吸电子基团; R1表示保护基团，其中每个R 1是单独的保护基团，或者两个R 1符号一起表示单个保护基团; 并且每个T独立地选自氢，1至约6个碳原子的低级烷基，吸电子基团和1至6个碳原子被吸电子基团取代的低级烷基。