公开(公告)号：US20050244341A1

公开(公告)日：2005-11-03

申请号：US11177719

申请日：2005-07-08

申请人： David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

发明人： David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/57 ,  A61K38/28 ,  A61K47/34 ,  A61L9/04 ,  G06F7/00 ,  G06F17/30

CPC分类号： A61K31/57 ,  A61K9/0075 ,  A61K9/1647 ,  A61K9/1682 ,  A61K38/28 ,  A61K47/34 ,  G06F16/284

摘要： Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.

摘要翻译： 提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。 在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成 集团在聚酯骨干。 在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。 空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

公开(公告)号：US20060002996A1

公开(公告)日：2006-01-05

申请号：US11176841

申请日：2005-07-07

申请人： David Edwards ,  Jeffrey Hrkach

发明人： David Edwards ,  Jeffrey Hrkach

IPC分类号： A61K38/28 ,  A61K9/127

CPC分类号： A61K9/0075 ,  A61K9/1617 ,  Y10S514/951 ,  Y10S514/97 ,  Y10S514/975

摘要： Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

摘要翻译： 具有改善的蛋白质稳定性的喷雾干燥颗粒通过喷雾干燥包括蛋白质，磷脂和有机 - 水性共溶剂的混合物而产生。 包含至少1重量％磷脂的喷雾干燥颗粒，其振实密度小于0.4g / cm 3，可以制备。 颗粒可以输送到患者的肺部系统。

公开(公告)号：US20050158249A1

公开(公告)日：2005-07-21

申请号：US11064065

申请日：2005-02-23

申请人： David Edwards ,  Giovanni Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdellaziz Ben-Jebria ,  Robert Langer

发明人： David Edwards ,  Giovanni Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdellaziz Ben-Jebria ,  Robert Langer

IPC分类号： A61K9/12 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61K31/137 ,  A61K47/32 ,  A61K48/00 ,  A61K31/353 ,  A61K31/4439 ,  A61K31/56 ,  A61K31/573 ,  A61K38/09

CPC分类号： A61K9/0075 ,  A61K9/1647 ,  A61K31/137

摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

公开(公告)号：US08641128B2

公开(公告)日：2014-02-04

申请号：US12537294

申请日：2009-08-07

申请人： David Edwards

发明人： David Edwards

IPC分类号： B62D27/02 ,  E04C5/16

CPC分类号： B62D25/2054

摘要： An insert that can be used support a vehicle floor if a cross member fails either mechanically or through corrosion. The insert may also be used to protect a fastener used in a vehicle floor assembly.

摘要翻译： 如果交叉构件机械地或通过腐蚀失效，则可以使用的插入件支撑车辆底板。 插入件也可用于保护用于车辆地板组件中的紧固件。

公开(公告)号：US08423280B2

公开(公告)日：2013-04-16

申请号：US13572279

申请日：2012-08-10

申请人： David Edwards ,  David Robert Pavlik ,  Ramkumar Subramanian ,  Robert Martin Coats

发明人： David Edwards ,  David Robert Pavlik ,  Ramkumar Subramanian ,  Robert Martin Coats

IPC分类号： G06F17/10 ,  B60Q1/00 ,  G01S13/00

CPC分类号： G01S13/931 ,  G01S7/062 ,  G01S13/862 ,  G01S13/865 ,  G01S13/867 ,  G01S13/87 ,  G01S17/023 ,  G01S2013/9332 ,  G01S2013/9353 ,  G01S2013/9364 ,  G01S2013/9367 ,  G01S2013/9389 ,  G08G1/16 ,  G08G1/166 ,  G08G1/167

摘要： A method for collision avoidance for a machine is disclosed. The method includes detecting an obstacle with an obstacle detection system and generating a corresponding signal. The obstacle detection system includes an operator input device. The method also includes providing an obstacle detection warning in response to the signal. The method further includes determining with a controller whether the operator input device has been activated in response to the obstacle detection warning.

摘要翻译： 公开了一种用于机器的防碰撞的方法。 该方法包括利用障碍物检测系统检测障碍物并产生相应的信号。 障碍物检测系统包括操作员输入装置。 该方法还包括响应于该信号提供障碍物检测警告。 该方法还包括利用控制器确定操作员输入装置是否已经响应于障碍物检测警告被激活。

公开(公告)号：US20080253971A9

公开(公告)日：2008-10-16

申请号：US10420071

申请日：2003-04-18

申请人： David Edwards ,  Robert Langer ,  Rita Vanbever ,  Jeffrey Mintzes ,  Jue Wang ,  Donghao Chen

发明人： David Edwards ,  Robert Langer ,  Rita Vanbever ,  Jeffrey Mintzes ,  Jue Wang ,  Donghao Chen

IPC分类号： A61K9/14 ,  A61L9/04 ,  A61K38/00

CPC分类号： A61K9/0073 ,  A61K9/0075 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1641 ,  A61K9/1647 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/135 ,  A61K31/137 ,  A61K31/566 ,  A61K38/28 ,  A61K38/38 ,  A61K47/12 ,  A61K47/183 ,  A61K47/24 ,  A61K47/6927

摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

公开(公告)号：US20080073239A1

公开(公告)日：2008-03-27

申请号：US11844493

申请日：2007-08-24

申请人： Paul Duffield ,  Geoffrey Hammond ,  David Edwards ,  William McCarthy ,  Arnold Beckett ,  Anthony Jackman

发明人： Paul Duffield ,  Geoffrey Hammond ,  David Edwards ,  William McCarthy ,  Arnold Beckett ,  Anthony Jackman

IPC分类号： B65D85/808

CPC分类号： C11D17/043 ,  A61G2205/00 ,  A61J3/07 ,  A61J3/071 ,  A61J3/072 ,  A61J3/08 ,  A61K9/4808 ,  A61K9/4816 ,  B29C45/0001 ,  B29C65/02 ,  B29C65/16 ,  B29C65/1612 ,  B29C65/1674 ,  B29C66/21 ,  B29C66/3452 ,  B29C66/54 ,  B29C2035/0822 ,  B29K2027/06 ,  B29K2029/04 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65D1/24 ,  B65D1/30 ,  B65D25/04 ,  B65D51/28 ,  B65D65/46 ,  B65D81/32 ,  B65D81/3205 ,  B65D81/3283 ,  B65D81/3294 ,  C11D11/007 ,  C11D17/042 ,  C11D17/045 ,  Y02W90/12 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/1379 ,  Y10T428/1397

摘要： A rigid, water-soluble container is made of an injection molded poly(vinyl alcohol) and/or a cellulose ether, which container encases a fabric care, surface care or dishwashing composition; and a capsule container comprising at least two components made of one or more material(s) that can be molded and which are water soluble or water dispersible or in which a substantial part of the surface of these components is water soluble or water dispersible so as to leave perforations throughout the wall when the capsular container is placed in contact with an aqueous environment. The container has one to six compartments, preferably one, two or three, the content of the various compartments being accessible to the aqueous environment when the capsular container is exposed to such an aqueous environment. The accessibility time of the various compartments is the same or different from one compartment to another compartment, with the proviso that the content of the container is not a fabric care, surface care or dishwashing composition.

摘要翻译： 刚性的水溶性容器由注射成型的聚（乙烯醇）和/或纤维素醚制成，该容器包含织物护理，表面护理或洗碗组合物; 以及胶囊容器，其包含至少两个由可以模制并且是水溶性或水分散性的一种或多种材料制成的部件，或者这些部件的大部分表面是水溶性或水分散性的，以便 当胶囊容器与水性环境接触时，穿过整个墙壁穿孔。 容器具有一至六个隔室，优选一个，二个或三个，当荚膜容器暴露于这种水性环境时，各种隔室的内容物可接触水溶液环境。 各个隔室的可接近时间与一个隔室相同或不同，另一个隔间是条件，即容器的内容物不是织物护理，表面护理或餐具清洗组合物。

公开(公告)号：US20080038207A1

公开(公告)日：2008-02-14

申请号：US11827031

申请日：2007-07-10

申请人： David Edwards ,  Mark Gabrielson ,  Robert Clarke ,  Wesley Dehaan ,  Matthew Brande ,  Jonathan Man

发明人： David Edwards ,  Mark Gabrielson ,  Robert Clarke ,  Wesley Dehaan ,  Matthew Brande ,  Jonathan Man

IPC分类号： A61K31/70 ,  A01N37/18

CPC分类号： A61B5/097 ,  G01N33/497

摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

公开(公告)号：US20070216534A1

公开(公告)日：2007-09-20

申请号：US11752482

申请日：2007-05-23

申请人： Scott Ferguson ,  David Edwards ,  Peikang Liu ,  Jason Munn ,  Ian Forster ,  Samuel Linder ,  Thomas Weakley ,  David Puleston ,  Steven Kennedy ,  Christine Dang

发明人： Scott Ferguson ,  David Edwards ,  Peikang Liu ,  Jason Munn ,  Ian Forster ,  Samuel Linder ,  Thomas Weakley ,  David Puleston ,  Steven Kennedy ,  Christine Dang

IPC分类号： G08B13/14

CPC分类号： G06K19/07752 ,  G06K19/07745 ,  G06K19/07749 ,  G06K19/07756 ,  H01L2224/16 ,  H01L2924/01046 ,  H01L2924/01079 ,  H01L2924/1461 ,  H01L2924/3011 ,  H01Q1/22 ,  H01Q1/2225 ,  H01Q1/38 ,  H01Q7/00 ,  Y10T29/49124 ,  H01L2924/00

摘要： A radio frequency identification (RIFD) inlay includes an electrical connection between a chip and an antenna. The electrical connection includes conductive interposer leads and a capacitive connection. The capacitive connection may involve putting the antenna and the interposer leads into close proximity, with dielectric pads therebetween, to allow capacitive coupling between the antenna and the interposer leads. The dielectric pads may include a non-conductive adhesive and a high dielectric material, such as a titanium oxide. The connections provide a convenient, fast, and effective way to operatively couple antennas and interposers. The RFID inlay may be part of an RFID label or RFID tag.

摘要翻译： 射频识别（RIFD）嵌体包括芯片和天线之间的电连接。 电气连接包括导电插入引线和电容连接。 电容连接可能涉及将天线和插入器引线紧密接合，其间具有介电垫，以允许天线和插入器引线之间的电容耦合。 介电垫可以包括非导电粘合剂和高介电材料，例如氧化钛。 这些连接提供了方便，快速和有效的方式来操作地耦合天线和插入器。 RFID嵌体可以是RFID标签或RFID标签的一部分。

公开(公告)号：US20070045819A1

公开(公告)日：2007-03-01

申请号：US11160997

申请日：2005-07-19

申请人： David Edwards ,  Sushumna Iruvanti ,  Hilton Toy ,  Wei Zou

发明人： David Edwards ,  Sushumna Iruvanti ,  Hilton Toy ,  Wei Zou

IPC分类号： H01L23/12

CPC分类号： H01L23/04 ,  H01L23/10 ,  H01L23/3675 ,  H01L23/42 ,  H01L24/32 ,  H01L2224/16225 ,  H01L2224/26175 ,  H01L2224/27013 ,  H01L2224/32245 ,  H01L2224/73253 ,  H01L2224/83051 ,  H01L2224/83385 ,  H01L2924/01005 ,  H01L2924/01013 ,  H01L2924/01033 ,  H01L2924/16152 ,  H01L2924/16153 ,  H01L2924/1616 ,  Y10S257/924

摘要： A semiconductor module structure and a method of forming the semiconductor module structure are disclosed. The structure incorporates a die mounted on a substrate and covered by a lid. A thermal compound is disposed within a thermal gap between the die and the lid. A barrier around the periphery of the die extends between the lid and the substrate, contains the thermal compound, and flexes in response to expansion and contraction of both the substrate and the lid during cycling of the semiconductor module. More particularly, either the barrier is formed of a flexible material or has a flexible connection to the substrate and/or to the lid. The barrier effectively contains the thermal compound between the die and the lid and, thereby, provides acceptable and controlled coverage of the thermal compound over the die for heat removal.