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    AMPEROMETRIC SENSORS AND DEVICES FOR MEASURING CONCENTRATION OF S-NITROSOTHIOLS BASED ON PHOTO-INDUCED DECOMPOSITION OF S-NITROSOTHIOLS
    1.
    发明申请
    AMPEROMETRIC SENSORS AND DEVICES FOR MEASURING CONCENTRATION OF S-NITROSOTHIOLS BASED ON PHOTO-INDUCED DECOMPOSITION OF S-NITROSOTHIOLS 有权
    用于测量S-NITROSOTOLOLS的光诱导分解的S-硝基酚的浓度的电位传感器和装置

    公开(公告)号：US20140014512A1

    公开(公告)日：2014-01-16

    申请号：US13264382

    申请日：2011-04-14

    申请人： Sung A Hong ,  Da Yeon Sung ,  Jun Hee Han ,  Jea Hun Song ,  Hakhyun Nam ,  Geun Sig Cha ,  Jae Ho Shin

    发明人： Sung A Hong ,  Da Yeon Sung ,  Jun Hee Han ,  Jea Hun Song ,  Hakhyun Nam ,  Geun Sig Cha ,  Jae Ho Shin

    IPC分类号： G01N27/30

    CPC分类号： G01N27/30 ,  G01N27/3271

    摘要： Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.

    摘要翻译： 提供了用于电化学量化亚硝基硫醇（RSNO）的电流传感器和装置，其与人体中一氧化氮（NO）的储存和递送相关。 用于测量RSNO浓度的电流传感器包括配置为测量由NO的氧化反应产生的电流的电极和被配置为启动和停止光诱导的RSNO分解的装置。 这里，通过在RSNO的光诱导分解之前和之后的NO的氧化反应来测量电流。 电流传感器可以使用一个电极同时测量样品中存在的RSNO和NO的单独信号，从而防止在RSNO测量期间由NO引起的抑制作用。 此外，电流传感器的结构简单，易于制造，并且可以应用于小电极的制造，因此可以被开发为用于体内测量的传感器。

    Miniaturized solid-state reference electrode with self-diagnostic function
    3.
    发明授权
    Miniaturized solid-state reference electrode with self-diagnostic function 失效
    具有自诊断功能的小型化固态参比电极

    公开(公告)号：US06554982B1

    公开(公告)日：2003-04-29

    申请号：US09889032

    申请日：2001-07-12

    申请人： Jae Ho Shin ,  Sung Dong Lee ,  Hakhyun Nam ,  Geun Sig Cha ,  Byeong Woo Bae

    发明人： Jae Ho Shin ,  Sung Dong Lee ,  Hakhyun Nam ,  Geun Sig Cha ,  Byeong Woo Bae

    IPC分类号： G01N27401

    CPC分类号： G01N27/301

    摘要： The present invention relates to a reference electrode for a potentiometric electrode system, characterized in that the junction in contact with a sample solution is enlarged and an ion-sensitive membrane containing an ion selective material as a protective membrane for the inner reference solution is employed, which comprises a substrate; a metal layer; an insoluble metal salt layer; an insulating film for insulating the metal layer from an aqueous solution; a hydrogel serving as an inner reference solution; the junction on the hydrogel contacting with a sample solution; the ion-sensitive, protective membrane formed over all surface areas of the hydrogel, except for the junction, to separate the sample solution from the inner reference solution or act as an ion-sensing membrane upon the contamination of the junction, whereby the operational abnormality caused by junction contamination may be easily checked and fast activation may be achieved.

    摘要翻译： 本发明涉及一种用于电位电极系统的参考电极，其特征在于，与样品溶液接触的接合点被扩大，并且使用含有作为内部参比溶液的保护膜的离子选择性材料的离子敏感膜， 其包括基底; 金属层; 不溶性金属盐层; 用于将金属层与水溶液绝缘的绝缘膜; 作为内参照溶液的水凝胶; 水凝胶上的接头与样品溶液接触; 在水凝胶的所有表面区域之外形成的离子敏感的保护膜除了接合部分之外，以将样品溶液与内部参考溶液分离，或者当接合部被污染时用作离子感测膜，由此操作异常 可以容易地检查结点污染引起的并且可以实现快速激活。

    Microchip-based carbon dioxide gas sensor
    5.
    发明授权
    Microchip-based carbon dioxide gas sensor 失效
    基于Microchip的二氧化碳气体传感器

    公开(公告)号：US06746583B2

    公开(公告)日：2004-06-08

    申请号：US09877857

    申请日：2001-06-08

    申请人： Jae Seon Lee ,  Jae Ho Shin ,  Min Hyung Lee ,  Hakhyun Nam ,  Geun Sig Cha

    发明人： Jae Seon Lee ,  Jae Ho Shin ,  Min Hyung Lee ,  Hakhyun Nam ,  Geun Sig Cha

    IPC分类号： G01N27327

    CPC分类号： G01N27/333 ,  G01N27/4162 ,  G01N33/004

    摘要： There is provided a microchip-based differential-type carbon dioxide gas sensor for detecting dissolved carbon dioxide levels. It functions with at least one working electrode composed of an unbuffered hydrogel membrane containing a certain amount of sodium bicarbonate and a pH-sensitive gas-permeable membrane; and a reference electrode composed of a buffered hydrogel membrane and a pH-sensitive gas-permeable membrane. The unbuffered hydrogel membrane contains carbonic anhydrase, which reduces the time period for the hydration of carbon dioxide, thereby allowing the quick measurement of the level of carbon dioxide. In addition to being significantly improved in stabilization, sensing, and recovering time periods, the differential-type carbon dioxide gas sensor can be fabricated in small sizes and quickly measure levels of carbon dioxide dissolved in sample solution.

    摘要翻译： 提供了一种用于检测溶解二氧化碳水平的基于微芯片的差分式二氧化碳气体传感器。 它与至少一个由含有一定量碳酸氢钠和pH敏感性透气膜的无缓冲水凝胶膜组成的工作电极起作用; 以及由缓冲水凝胶膜和pH敏感性透气膜构成的参比电极。 无缓冲水凝胶膜含有碳酸酐酶，减少了二氧化碳水化的时间，从而可以快速测定二氧化碳的含量。 除了稳定化，感测和恢复时间段的显着改进之外，差分型二氧化碳气体传感器可以制造成小尺寸并且快速测量溶解在样品溶液中的二氧化碳的水平。

    Method for fabricating biosensors using hydrophilic polyurethane
    6.
    发明授权
    Method for fabricating biosensors using hydrophilic polyurethane 有权
    使用亲水性聚氨酯制造生物传感器的方法

    公开(公告)号：US06509148B2

    公开(公告)日：2003-01-21

    申请号：US09485513

    申请日：2000-02-10

    申请人： Geun Sig Cha ,  Hakhyun Nam ,  Jae Ho Shin

    发明人： Geun Sig Cha ,  Hakhyun Nam ,  Jae Ho Shin

    IPC分类号： C12Q100

    CPC分类号： C12Q1/002

    摘要： Disclosed is a method for fabricating biosensors, using hydrophilic polyurethane. Bio-active reagents, including enzymes, antibodies, antigens, cells and receptors, are mixed with hydrophilic polyurethane and the mixture is directly coated over a signal transducer to form a sensing film which serves as a signal detector. The method using hydrophilic polyurethane allows the simplification of the fabrication of biosensors without conducting complicated chemical reactions and washing steps, such as crosslinking. The bio-active reagent entrapped within the hydrophilic polyurethane film can retains its high activity for an extended period of time and the intrinsic potentiometric response of the underlying ion-selective polymeric membrane is not affected by the bio-active reagent immobilized polyurethane film coated on its sensing surface. Therefore, the biosensors are superior in specificity, selectivity, and stability. Also, the adoption of solid-state type electrodes by virtue of the direct immobilization of the bio-active reagents allows the biosensors to be miniaturized, offering the advantages of the detection of small quantities of samples and mass production for low cost.

    摘要翻译： 公开了使用亲水性聚氨酯制造生物传感器的方法。 将生物活性试剂（包括酶，抗体，抗原，细胞和受体）与亲水性聚氨酯混合，并将混合物直接涂覆在信号传感器上以形成用作信号检测器的感测膜。 使用亲水性聚氨酯的方法允许简化生物传感器的制造，而不进行复杂的化学反应和洗涤步骤，例如交联。 包埋在亲水性聚氨酯膜内的生物活性试剂可以在长时间内保持其高活性，并且潜在的离子选择性聚合物膜的固有电位响应不受其上涂覆的生物活性试剂固定化聚氨酯膜的影响 传感表面。 因此，生物传感器的特异性，选择性和稳定性优异。 此外，通过生物活性试剂的直接固定，采用固态电极使得生物传​​感器小型化，提供少量样品的检测和低成本的批量生产的优点。

    Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof
    7.
    发明授权
    Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof 有权
    基于苯基乙酸的4-（三氟乙酰基）苯基衍生物，其制备方法和用途

    公开(公告)号：US06177417B1

    公开(公告)日：2001-01-23

    申请号：US09338028

    申请日：1999-06-22

    申请人： Junho Chu ,  Hyung Jung Pyun ,  In Jun Yoon ,  Jae Ho Shin ,  Hakhyun Nam ,  Geun Sig Cha

    发明人： Junho Chu ,  Hyung Jung Pyun ,  In Jun Yoon ,  Jae Ho Shin ,  Hakhyun Nam ,  Geun Sig Cha

    IPC分类号： A61K3156

    CPC分类号： A61K31/56 ,  C07J9/00

    摘要： The present invention relates to a cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the following formula 1, process for preparation and use thereof. The cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the present invention may be used as a host material in the host-guest chemistry, in detail as a material for ion sensors, optical sensors, gas sensors, biosensors, chromatographies, photostimulated ion-binding resins, ion exchange resins and organic reactions. (In the above formula 1, R, R1, R2, R3 and n are defined in the specifications).

    摘要翻译： 本发明涉及下述通式1的4-（三氟乙酰基）苯基衍生物，其制备方法和使用方法。 作为离子传感器，光学传感器，气体传感器，生物传感器，色谱，光刺激的材料，可以将本发明的基于胆酸的环状4-（三氟乙酰基）苯基衍生物用作主客体化学中的主体材料 离子结合树脂，离子交换树脂和有机反应（在上述式1中，R，R 1，R 2，R 3和n在规格中定义）。

    Reference electrode with a polymeric reference electrode membrane
    8.
    发明授权
    Reference electrode with a polymeric reference electrode membrane 失效
    具有聚合物参比电极膜的参比电极

    公开(公告)号：US06793789B2

    公开(公告)日：2004-09-21

    申请号：US09960432

    申请日：2001-09-22

    申请人： Yong Suk Choi ,  Sung Dong Lee ,  Seong Hee Oh ,  Hyo Lin Lee ,  Jae Ho Shin ,  Jeonghan Ha ,  Hakhyun Nam ,  Geun Sig Cha

    发明人： Yong Suk Choi ,  Sung Dong Lee ,  Seong Hee Oh ,  Hyo Lin Lee ,  Jae Ho Shin ,  Jeonghan Ha ,  Hakhyun Nam ,  Geun Sig Cha

    IPC分类号： G01N2731

    CPC分类号： G01N27/301

    摘要： Disclosed is a polymeric reference electrode membrane comprising (a) one selected from a porous polymer or a hydrophilic plasticizer; (b) a lipophilic polymer; and optionally an adhesion-enhancing material. A reference electrode equipped with the polymeric reference electrode membrane can be shortened the preconditioning time, and extended lifetime for storage and use owing to excellent adhesion, and showed reproducibility and good yield. So, a miniaturized multi-potentiometric sensor can be fabricated comprising a solid-state reference electrode of the present invention and a set of ion-selective electrodes, thus being useful in the potentiometric fields, including clinical, environmental, food and industrial analysis.

    摘要翻译： 公开了一种聚合物参比电极膜，其包含（a）选自多孔聚合物或亲水性增塑剂中的一种; （b）亲脂性聚合物; 和任选的粘附增强材料。 配备有聚合物参比电极膜的参比电极可以缩短预处理时间，并且由于优异的粘附性而延长存储和使用寿命，并且显示出重现性和良好的产率。 因此，可以制造包括本发明的固态参考电极和一组离子选择性电极的小型化多电位传感器，因此可用于电位计领域，包括临床，环境，食品和工业分析。

    Nitric oxide microsensors via fluorosilane-based xerogel membranes
    10.
    发明授权
    Nitric oxide microsensors via fluorosilane-based xerogel membranes 有权
    一氧化氮微量传感器通过基于氟硅烷的干凝胶膜

    公开(公告)号：US08551322B2

    公开(公告)日：2013-10-08

    申请号：US12374932

    申请日：2007-08-24

    申请人： Mark H. Schoenfisch ,  Jae Ho Shin

    发明人： Mark H. Schoenfisch ,  Jae Ho Shin

    IPC分类号： G01N27/26 ,  G01F1/64 ,  B05D5/12 ,  C08G77/24

    CPC分类号： G01N27/4072 ,  G01N27/4045 ,  Y10T428/31663

    摘要： The presently disclosed subject matter relates to sensors for measuring an amount of a gaseous species in a sample. The sensors comprise a gas permeable polysiloxane network membrane, comprising both alkyl and fluorinated alkyl groups. In some embodiments, the polysiloxane network can be formed from the co-condensation of a mixture of an alkylalkoxysilane and a fluorosilane. The presently disclosed subject matter also relates to methods of making the sensors, methods of selectively measuring an amount of a gaseous species, such as nitric oxide, in a sample, and to compositions comprising the polysiloxane networks.

    摘要翻译： 目前公开的主题涉及用于测量样品中气态物质的量的传感器。 传感器包括含有烷基和氟化烷基的透气性聚硅氧烷网膜。 在一些实施方案中，聚硅氧烷网络可以由烷基烷氧基硅烷和氟硅烷的混合物的共缩合形成。 目前公开的主题还涉及制造传感器的方法，选择性地测量样品中气态物质如一氧化氮的量的方法以及包含聚硅氧烷网络的组合物。