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1.发明申请EPIDERMAL GROWTH FACTOR INCREASING INSULIN SECRETION AND LOWERING BLOOD GLUCOSE 审中-公开生长因子增加胰岛素分泌和降低血糖公开(公告)号：US20090312250A1
公开(公告)日：2009-12-17
申请号：US12373691
申请日：2007-07-16
申请人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Hye-Young Lee , Kyung-Moo Yea , Byoung-Dae Lee , Young-Chan Chae , Hyeon-Soo Kim , Seon-Hee Kim , Pann-Ghill Suh
IPC分类号： A61K38/18
CPC分类号： A61K38/1808
摘要： The present inventors show that a brief exposure to EGF stimulates insulin secretion glucose-independently via a Ca2+ influx- and PLD2-dependent mechanism. Furthermore, the present invention shows that EGF is a novel secretagogue that lowers plasma glucose levels in normal and diabetic mice, suggesting the potential for EGF treatment in diabetes.
摘要翻译： 本发明人表明，EGF的短暂暴露通过Ca2 +流入和PLD2依赖性机制独立地刺激胰岛素分泌葡萄糖。 此外，本发明显示EGF是降低正常糖尿病小鼠血浆葡萄糖水平的新型促分泌素，表明在糖尿病中EGF治疗的潜力。
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2.发明申请Glucose uptake modulator and method for treating diabetes or diabetic complications 审中-公开葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法公开(公告)号：US20100120662A1
公开(公告)日：2010-05-13
申请号：US12657083
申请日：2010-01-13
申请人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K38/28 , A61K31/661 , A61K38/16 , A61P3/10
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要翻译： 本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂 。
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3.发明申请Glucose Uptake Modulator and Method for Treating Diabetes or Diabetic Complications 审中-公开葡萄糖摄取调节剂及治疗糖尿病并发症的方法公开(公告)号：US20080207490A1
公开(公告)日：2008-08-28
申请号：US11994380
申请日：2006-07-07
申请人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Kyung-Moo Yea , Jae-Yoon Kim , Jong-Hyun Kim , Byoung-Dae Lee , Seung-Je Lee , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an effecting amount of a glucose uptake modulator.
摘要翻译： 本发明涉及葡萄糖摄取调节剂，包含葡萄糖摄取调节剂的药物组合物和治疗有此需要的哺乳动物的糖尿病或糖尿病并发症的方法，其包括对所述哺乳动物施用有效量的葡萄糖摄取调节剂 。
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4.发明申请LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE 审中-公开调节免疫反应的配对及其在治疗免疫反应相关疾病中的应用公开(公告)号：US20100291089A1
公开(公告)日：2010-11-18
申请号：US11993655
申请日：2006-07-07
申请人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
发明人： Youn-Dong Kim , Byoung-Dae Lee , Yoe-Kyung Kim , Yoe-Sik Bae , Tae-Hoon Lee , Pann-Ghill Suh , Sung-Ho Ryu
IPC分类号： A61K39/395 , C07K14/435 , A61K38/08 , A61K39/10 , A61K31/5377 , A61K31/352 , A61K31/713 , A61P37/02 , A61P29/00 , A61P25/28 , A61P9/10 , A61P35/00
CPC分类号： A61K38/1796 , A61K38/08
摘要： The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA).
摘要翻译： 本发明涉及调节免疫应答的配体，即垂体腺苷酸环化酶活化多肽和血清淀粉样蛋白A（SAA）之一的PACAP27及其在治疗或预防与免疫应答有关的疾病中的新用途。 更具体地，本发明涉及具有对免疫应答的调节作用的PACAP27-FPRL1的复合物及其在调节免疫应答中的用途。 另一方面，本发明涉及SAA和FPRL1的复合物及其在抑制滑膜细胞增生和血管生成中的用途，并且治疗或预防包括类风湿性关节炎（RA）在内的炎性疾病。
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公开(公告)号：US07074891B2
公开(公告)日：2006-07-11
申请号：US10774147
申请日：2004-02-05
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。
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6.发明授权Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor 失效通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素活性的方法公开(公告)号：US08278263B2
公开(公告)日：2012-10-02
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong Heon Kim , Sung-Key Jang , Tae-Hoon Lee
IPC分类号： A61K38/02
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
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公开(公告)号：US20060166888A1
公开(公告)日：2006-07-27
申请号：US11277343
申请日：2006-03-23
申请人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
发明人： Sung-Ho Ryu , Yoe-Sik Bae , Eun-Young Park , Pann-Ghill Suh
摘要： The present application describes peptides that stimulate arachidonic acid release in target cells. The application also discloses peptides that cause intracellular calcium release.
摘要翻译： 本申请描述了刺激靶细胞中花生四烯酸释放的肽。 本申请还公开了引起细胞内钙释放的肽。
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公开(公告)号：US06887484B2
公开(公告)日：2005-05-03
申请号：US10209802
申请日：2002-07-31
申请人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
发明人： Yoe-Sik Bae , Youn-Dong Kim , You-Suk Seo , Young-Chul Sung , Pann-Ghill Suh , Sung-Ho Ryu , Taehoon Lee
CPC分类号： C07K14/005 , A61K39/12 , A61K39/29 , A61K2039/545 , A61K2039/55505 , A61K2039/575 , C07K2319/00 , C12N2770/24222 , C12N2770/24234 , Y02A50/466
摘要： A vaccine having a good vaccination effect, which comprises an antigen; a peptide selected from the group consisting of a peptide having the amino acid sequence of SEQ ID NO: 1, a peptide having the amino acid sequence of SEQ ID NO: 2, and a peptide derived from a peptide having the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2; and an immune activator.
摘要翻译： 具有良好疫苗接种效果的疫苗，其包含抗原; 选自具有SEQ ID NO：1的氨基酸序列的肽，具有SEQ ID NO：2的氨基酸序列的肽和源自SEQ ID NO：2的氨基酸序列的肽的肽的肽 ID NO：1或SEQ ID NO：2; 和免疫激活剂。
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9.发明授权Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb 失效通过磷脂酶D和Rheb之间的相互作用调节哺乳动物雷帕霉素活性的方法公开(公告)号：US08168177B2
公开(公告)日：2012-05-01
申请号：US12374239
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Mi-Nam Lee , Hyun-Ju Lee , Il-Shin Kim , Do-Hyung Kim , Tae-Hoon Lee
CPC分类号： C12Q1/485 , A61K38/00 , C12N9/16 , C12Q1/34 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及基于由磷脂酶D（PLD）和富含脑（Rheb）的Ras同源物的mTOR调节机制的新发现调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
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10.发明申请Method of Regulating Mammalian Target-of-Rapamycin Activity by Interaction Between Phospholipase D and Raptor 失效通过磷脂酶D和猛禽相互作用调节哺乳动物雷帕霉素目标的方法公开(公告)号：US20100184636A1
公开(公告)日：2010-07-22
申请号：US12374262
申请日：2007-08-03
申请人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
发明人： Sung-Ho Ryu , Pann-Ghill Suh , Sang-Hoon Ha , Do-Hyung Kim , Il-Shin Kim , Jung-Hwan Kim , Mi-Nam Lee , Hyun-Ju Lee , Jong-Heon Kim , Sung-Key Jang , Tae-Hoon Lee
CPC分类号： A61K38/1709 , C07K14/4702 , C12N9/20 , C12Y301/04004 , G01N33/5011 , G01N2333/9121 , G01N2333/916
摘要： The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
摘要翻译： 本发明涉及通过调节与mTOR产生复合物的磷脂酶D（PLD）活性来调节哺乳动物雷帕霉素靶（mTOR）的方法。 此外，本发明还涉及一种筛选mTOR抑制剂的方法，以及通过抑制mTOR来治疗mTOR相关代谢疾病的方法和组合物。
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