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公开(公告)号：US20090036554A1
公开(公告)日：2009-02-05
申请号：US12177171
申请日：2008-07-22
CPC分类号： A61L12/14 , A61L12/142 , A61L12/143 , A61L12/147
摘要： An aqueous ophthalmic composition comprising one or more terpene compounds, and one or more natural polymers selected from the group comprising hyaluronic acid, condroitin sulfate, alginate, guar gum, fructan, arabinogalactan or any corresponding salt or derivative of each thereof. The compositions can be used to disinfect or package a contact lens, or as an eye drop to comfort irritated eyes or rewet a contact lens.
摘要翻译： 一种含有一种或多种萜烯化合物的水性眼用组合物，以及一种或多种选自透明质酸，硫酸伦硫酸盐，藻酸盐，瓜尔胶，果聚糖，阿拉伯半乳聚糖或其任何相应的盐或衍生物的天然聚合物。 该组合物可用于消毒或包装隐形眼镜，或作为眼药水来舒适地刺激眼睛或再湿润隐形眼镜。
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公开(公告)号：US20130202547A1
公开(公告)日：2013-08-08
申请号：US13366398
申请日：2012-02-06
CPC分类号： A01N33/12 , A01N37/46 , A01N47/44 , A61L12/142 , A01N55/08
摘要： Ophthalmic composition that includes 0.05% w/v to 2% w/v diglycine or a salt thereof; 0.01 ppm to 3 ppm poly(hexamethylene biguanide); 1 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride; and 0.1% w/v to 2% w/v of one or more boron buffering compounds.
摘要翻译： 包含0.05％w / v至2％w / v二甘氨酸或其盐的眼用组合物; 0.01ppm至3ppm聚（六亚甲基双胍）; 1ppm至10ppm的α-[4-三（2-羟乙基）氯化铵-2-丁烯基]聚[1-二甲基氯化铵-2-丁烯基] - 三（2-羟乙基）氯化铵; 和0.1％w / v至2％w / v的一种或多种硼缓冲化合物。
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公开(公告)号：US08138156B2
公开(公告)日：2012-03-20
申请号：US11873703
申请日：2007-10-17
CPC分类号： A61K9/0048 , A61K31/194 , A61K47/183 , C11D3/0078 , C11D3/046 , C11D3/33 , Y10S514/912
摘要： Ophthalmic composition comprising one or more polyglycines selected from the group consisting of diglycine, triglycine, tetraglycine and pentaglycine, or the salts of each thereof and one or more boron buffering compounds. The ophthalmic composition will have an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.
摘要翻译： 包含一种或多种选自二甘氨酸，三甘氨酸，四甘氨酸和五聚甘氨酸的聚甘氨酸或其各自的盐和一种或多种硼缓冲化合物的眼科组合物。 眼用组合物的重量摩尔渗透压浓度为200mOsmol / kg至420mOsmol / kg。
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公开(公告)号：US20100178317A1
公开(公告)日：2010-07-15
申请号：US12684363
申请日：2010-01-08
摘要： A method of retaining hyaluronic acid on a surface of a contact lens. The method comprises providing a contact lens care solution comprising; 0.005 wt. % to 0.05 wt. % of hyaluronic acid in a borate containing buffer, and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R′ is a C8-C16alkyl optionally substituted with hydroxyl; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl; and soaking the contact lens in the contact lens care solution for at least two hours prior to placement of the contact lens in an eye.
摘要翻译： 保留隐形眼镜表面上透明质酸的方法。 该方法包括提供隐形眼镜护理溶液，其包含： 0.005重量％ ％〜0.05重量％ 含硼酸盐缓冲液中透明质酸的百分比，和0.01重量％ ％〜1.0wt ％的通式I的两性表面活性剂，其中R'是任选被羟基取代的C 8 -C 16烷基; R2和R3各自独立地选自甲基，乙基，丙基或异丙基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基; 并将隐形眼镜在隐形眼镜护理溶液中浸泡至少两个小时，然后将隐形眼镜放置在眼睛中。
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公开(公告)号：US08530641B2
公开(公告)日：2013-09-10
申请号：US13564161
申请日：2012-08-01
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
IPC分类号： A61K31/728 , C08B37/00 , C08B37/08
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 含有重量平均分子量为0.6MDa至3.6Mda的0.04％至0.8％重量的透明质酸和一种或多种选自硼酸，硼酸钠和磷酸二氢钠的缓冲成分的灭菌水溶液。 水溶液的离子强度相当于氯化钠的水溶液浓度为4〜18重量％，pH为6.4〜7.2。 该溶液也通过平均孔径为0.25μm或更小的过滤介质过滤以提供无菌的高盐透明质酸溶液。
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6.发明申请OPHTHALMIC COMPOSITIONS WITH AN AMPHOTERIC SURFACTANT AND HYALURONIC ACID 有权具有AMPHOTERIC表面活性剂和羟丙酸的眼科组合物公开(公告)号：US20090196846A1
公开(公告)日：2009-08-06
申请号：US12203384
申请日：2008-09-03
申请人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
发明人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
CPC分类号： C11D3/48 , A01N33/12 , A01N47/44 , A61K9/0048 , A61K31/155 , A61K31/728 , A61K45/06 , A61L12/14 , A61L12/141 , A61L12/142 , A61L12/143 , C11D1/88 , C11D1/92 , C11D3/0078 , C11D3/227 , C11D3/26 , Y10S514/912 , A01N25/30 , A01N2300/00 , A61K2300/00
摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
摘要翻译： 包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％ ％〜0.15wt。 ％的透明质酸; 和0.01重量％ ％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。 本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。
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公开(公告)号：US08664180B2
公开(公告)日：2014-03-04
申请号：US13366398
申请日：2012-02-06
CPC分类号： A01N33/12 , A01N37/46 , A01N47/44 , A61L12/142 , A01N55/08
摘要： Ophthalmic composition that includes 0.05% w/v to 2% w/v diglycine or a salt thereof; 0.01 ppm to 3 ppm poly(hexamethylene biguanide); 1 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride; and 0.1% w/v to 2% w/v of one or more boron buffering compounds.
摘要翻译： 包含0.05％w / v至2％w / v二甘氨酸或其盐的眼用组合物; 0.01ppm至3ppm聚（六亚甲基双胍）; 1ppm至10ppm的α-[4-三（2-羟乙基）氯化铵-2-丁烯基]聚[1-二甲基氯化铵-2-丁烯基] - 三（2-羟乙基）氯化铵; 和0.1％w / v至2％w / v的一种或多种硼缓冲化合物。
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公开(公告)号：US20110195925A1
公开(公告)日：2011-08-11
申请号：US12702540
申请日：2010-02-09
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 一种对包含透明质酸的溶液进行灭菌的方法。 该方法包括提供重均分子量为0.6MDa至3.6MDa的透明质酸水溶液，透明质酸的浓度为0.04％至0.8％重量。 水溶液的离子强度相当于氯化钠水溶液的重量的3〜30重量％。 一旦制备了含水高盐透明质酸溶液，将溶液保持在40℃至80℃的温度下至少1小时且不超过6天。 在热处理步骤之后，通过灭菌过滤介质过滤水溶液，得到无菌高盐透明质酸溶液。
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公开(公告)号：US20090247469A1
公开(公告)日：2009-10-01
申请号：US12054577
申请日：2008-03-25
申请人： Susan E. Burke
发明人： Susan E. Burke
CPC分类号： A61K9/0048 , A61K31/155 , A61K38/05 , A61K47/18 , A61K47/186 , A61K2300/00
摘要： An ophthalmic composition comprising one or more antimicrobial components and a dipeptide. The dipeptide comprises a glycine moiety and another amino acid moiety other than glycine. The ophthalmic compositions include contact lens care solutions for cleaning and disinfecting contact lenses.
摘要翻译： 一种眼科组合物，其包含一种或多种抗微生物组分和二肽。 二肽包含甘氨酸部分和除甘氨酸以外的另一个氨基酸部分。 眼用组合物包括用于清洁和消毒隐形眼镜的隐形眼镜护理溶液。
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公开(公告)号：US20080312182A1
公开(公告)日：2008-12-18
申请号：US12109599
申请日：2008-04-25
申请人： Susan E. Burke , Srini Venkastesh
发明人： Susan E. Burke , Srini Venkastesh
IPC分类号： A61K31/728 , A61P27/02
CPC分类号： C11D1/90 , A61L12/142 , C11D1/92 , C11D3/0078 , C11D3/222 , C11D3/227 , C11D3/3723 , C11D3/48
摘要： An ophthalmic composition comprising 0.5 ppm to 3 ppm of poly(hexamethylene biguanide), and 0.002 wt. % to 0.03 wt. % of hyaluronic acid. The weight ratio of hyaluronic acid to poly(hexamethylene biguanide) in the composition is from 45:1 to 120:1. The invention is also directed to a method of cleaning, disinfecting or packaging contact lenses with the composition, or to a method of rewetting contact lenses with the composition.
摘要翻译： 包含0.5ppm至3ppm的聚（六亚甲基双胍）和0.002wt。 ％〜0.03重量％ ％的透明质酸。 组合物中透明质酸与聚（六亚甲基双胍）的重量比为45:1-120:1。 本发明还涉及一种用该组合物清洁，消毒或包装隐形眼镜的方法，或涉及一种使该组合物再湿润隐形眼镜的方法。
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