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公开(公告)号：US20100324122A1
公开(公告)日：2010-12-23
申请号：US12145470
申请日：2008-06-24
申请人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
发明人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12Q1/6886 , C12Q2600/158 , C12N2310/3525 , C12N2310/3527
摘要： Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SGLT2的表达。 组合物包含靶向编码SGLT2的核酸的寡核苷酸。 提供了使用这些化合物调节SGLT2表达和用于诊断和治疗与SGLT2表达相关的疾病和病症的方法。
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公开(公告)号：US20120196921A1
公开(公告)日：2012-08-02
申请号：US13300404
申请日：2011-11-18
申请人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
发明人： Susan M. Freier , Edward Wancewicz , Brett P. Monia , Andrew M. Siwkowski , Lynnetta Watts , Thomas A. Leedom
IPC分类号： A61K31/711 , A61P3/08 , A61K31/7105 , A61P3/10 , C07H21/04 , C07H21/02
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12Q1/6886 , C12Q2600/158 , C12N2310/3525 , C12N2310/3527
摘要： Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SGLT2的表达。 组合物包含靶向编码SGLT2的核酸的寡核苷酸。 提供了使用这些化合物调节SGLT2表达和用于诊断和治疗与SGLT2表达相关的疾病和病症的方法。
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公开(公告)号：US08084436B2
公开(公告)日：2011-12-27
申请号：US12145470
申请日：2008-06-24
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12Q1/6886 , C12Q2600/158 , C12N2310/3525 , C12N2310/3527
摘要： Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SGLT2的表达。 组合物包含靶向编码SGLT2的核酸的寡核苷酸。 提供了使用这些化合物调节SGLT2表达和用于诊断和治疗与SGLT2表达相关的疾病和病症的方法。
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公开(公告)号：US08258105B2
公开(公告)日：2012-09-04
申请号：US10946498
申请日：2004-09-21
申请人： Andrew M. Siwkowski , Edward Wancewicz , Thomas A. Leedom , Lynnetta Watts , Mausumee Guha , Brett P. Monia
发明人： Andrew M. Siwkowski , Edward Wancewicz , Thomas A. Leedom , Lynnetta Watts , Mausumee Guha , Brett P. Monia
IPC分类号： C12N15/11
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12N2310/3525 , C12N2310/3527
摘要： The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes SGLT2 and connective tissue growth factor (CTGF) in the kidney.
摘要翻译： 本发明提供了用于调节在肾中表达的靶基因的表达的反义化合物和方法。 特别地，本发明提供针对在肾中表达的靶向核酸分子而优化的反义寡核苷酸化合物。 本文显示了这样的化合物以有效调节肾脏中靶基因SGLT2和结缔组织生长因子（CTGF）的表达。
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公开(公告)号：US20100222412A1
公开(公告)日：2010-09-02
申请号：US12687533
申请日：2010-01-14
申请人： Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
发明人： Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for treatment of diseases are provided.
摘要翻译： 提供化合物，组合物和方法用于调节糖皮质激素受体的表达。 组合物包含靶向编码糖皮质激素受体的核酸的反义化合物，特别是具有特定体内特性的反义寡核苷酸。 提供了使用这些化合物调节糖皮质激素受体表达和治疗疾病的方法。
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公开(公告)号：US07919476B2
公开(公告)日：2011-04-05
申请号：US11697280
申请日：2007-04-05
申请人： Sanjay Bhanot , Lynnetta Watts , Robert McKay , Susan M. Freier
发明人： Sanjay Bhanot , Lynnetta Watts , Robert McKay , Susan M. Freier
IPC分类号： A61K48/00
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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公开(公告)号：US20050191653A1
公开(公告)日：2005-09-01
申请号：US10980002
申请日：2004-11-02
申请人： Susan Freier , Edward Wancewicz , Brett Monia , Andrew Siwkowski , Lynnetta Watts , Thomas Leedom
发明人： Susan Freier , Edward Wancewicz , Brett Monia , Andrew Siwkowski , Lynnetta Watts , Thomas Leedom
IPC分类号： A61K31/70 , A61K48/00 , C07H20060101 , C07H21/02 , C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12Q1/6886 , C12Q2600/158 , C12N2310/3525 , C12N2310/3527
摘要： Compounds, compositions and methods are provided for modulating the expression of SGLT2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SGLT2. Methods of using these compounds for modulation of SGLT2 expression and for diagnosis and treatment of diseases and conditions associated with expression of SGLT2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SGLT2的表达。 组合物包含靶向编码SGLT2的核酸的寡核苷酸。 提供了使用这些化合物调节SGLT2表达和用于诊断和治疗与SGLT2表达相关的疾病和病症的方法。
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公开(公告)号：US20070299028A1
公开(公告)日：2007-12-27
申请号：US11679159
申请日：2007-02-26
申请人： Andrew Siwkowski , Edward Wancewicz , Thomas Leedom , Lynnetta Watts , Mausumee Guha , Brett Monia , Richard Griffey , Richard Geary , Scott Henry , Arthur Levin
发明人： Andrew Siwkowski , Edward Wancewicz , Thomas Leedom , Lynnetta Watts , Mausumee Guha , Brett Monia , Richard Griffey , Richard Geary , Scott Henry , Arthur Levin
IPC分类号： A61K31/7088 , A61P3/00 , A61P3/10 , C07H21/00
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12N2310/3525 , C12N2310/3527
摘要： The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes PTEN, SGLT2 and connective tissue growth factor (CTGF) in the kidney.
摘要翻译： 本发明提供了用于调节在肾中表达的靶基因的表达的反义化合物和方法。 特别地，本发明提供针对在肾中表达的靶向核酸分子而优化的反义寡核苷酸化合物。 本文显示了这样的化合物以有效调节肾脏中靶基因PTEN，SGLT2和结缔组织生长因子（CTGF）的表达。
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公开(公告)号：US20050113326A1
公开(公告)日：2005-05-26
申请号：US10946498
申请日：2004-09-21
申请人： Andrew Siwkowski , Edward Wancewicz , Thomas Leedom , Lynnetta Watts , Mausumee Guha , Brett Monia
发明人： Andrew Siwkowski , Edward Wancewicz , Thomas Leedom , Lynnetta Watts , Mausumee Guha , Brett Monia
IPC分类号： A61K31/70 , A61K48/00 , C07H20060101 , C07H21/02 , C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N15/111 , C12N15/1136 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/32 , C12N2500/40 , C12N2310/3525 , C12N2310/3527
摘要： The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes SGLT2 and connective tissue growth factor (CTGF) in the kidney.
摘要翻译： 本发明提供了用于调节在肾中表达的靶基因的表达的反义化合物和方法。 特别地，本发明提供针对在肾中表达的靶向核酸分子而优化的反义寡核苷酸化合物。 本文显示了这样的化合物以有效调节肾脏中靶基因SGLT2和结缔组织生长因子（CTGF）的表达。
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公开(公告)号：US20070238690A1
公开(公告)日：2007-10-11
申请号：US11697280
申请日：2007-04-05
申请人： Sanjay Bhanot , Lynnetta Watts , Robert McKay
发明人： Sanjay Bhanot , Lynnetta Watts , Robert McKay
IPC分类号： A61K31/7088 , A61K31/7125
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
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