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公开(公告)号：US20100004292A1
公开(公告)日：2010-01-07
申请号：US11991670
申请日：2006-08-26
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/4439 , C07D263/28 , C07D413/14 , C07D277/18 , A61K31/422 , A61K31/427 , C12N5/06 , A61P7/02
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： The present application relates to novel iminooxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本申请涉及新的亚氨基恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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2.发明申请公开(公告)号：US20100041646A1
公开(公告)日：2010-02-18
申请号：US12084267
申请日：2006-10-20
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C07D413/14 , A61K31/5355 , A61P7/02 , C12N5/00
CPC分类号： C07D413/14
摘要： The present application relates to novel 1,4-phenylene-bis-oxazolidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本申请涉及新的1,4-亚苯基 - 双恶唑烷衍生物，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是血栓栓塞性疾病。
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公开(公告)号：US20080214533A1
公开(公告)日：2008-09-04
申请号：US11792108
申请日：2005-11-22
申请人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
发明人： Susanne Rohrig , Jens Pohlmann , Sabine Arndt , Mario Jeske , Metin Akbaba , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Arounarith Tuch , Mario Lobell , Peter Nell , Nils Burkhardt
IPC分类号： A61K31/5355 , C07D401/14 , C07D413/14 , A61K31/4439 , C07D417/14 , A61K31/497 , A61P7/00
CPC分类号： C07D413/14
摘要： The invention relates to novel cyclic iminocarbamates of formula (I), wherein R1, R2, R3, A, Z, and n have the meanings recited in the description, to a method for the production thereof, to pharmaceutical compositions containing such materials, and to methods for the treatment and/or prophylaxis of thromboembolic diseases using them.
摘要翻译： 本发明涉及式（I）的新型环状亚氨基化物，其中R 1，R 2，R 3，A，Z和n 具有本说明书中所述的含义，其制备方法，含有这些材料的药物组合物，以及使用它们治疗和/或预防血栓栓塞性疾病的方法。
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公开(公告)号：US20060287315A1
公开(公告)日：2006-12-21
申请号：US11299342
申请日：2005-12-08
申请人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
发明人： Susanne Rohrig , Mario Jeske , Metin Akbaba , Ulrich Rosentreter , Stephen Boyer , Karin Fischer , Jens Pohlmann , Arounarith Tuch , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Nils Burkhardt , Swen Allerheiligen , Peter Nell , Sabine Arndt , Mario Lobell
IPC分类号： A61K31/5377 , A61K31/497 , C07D413/02 , C07D403/02
CPC分类号： C07D491/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel pyridinedicarboxamides, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的吡啶二酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。
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5.发明申请AMINOACYL PRODRUGS AS AN ACTIVE PHARMACEUTICAL INGREDIENT FOR THROMBOEMBOLIC DISORDERS 审中-公开作为血栓性疾病的活性药物成分的氨基酸制剂公开(公告)号：US20110172232A1
公开(公告)日：2011-07-14
申请号：US12668590
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -2-氧代-1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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公开(公告)号：US20100273789A1
公开(公告)日：2010-10-28
申请号：US12668619
申请日：2008-06-28
申请人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
发明人： Hans-Georg Lerchen , Ursula Krenz , Michael Härter , Mark Jean Gnoth , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Anja Buchmüller , Susanne Röhrig , Swen Allerheiligen , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer , Metin Akbaba
IPC分类号： A61K31/5377 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[2-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译： 本申请涉及5-氯-N - （{（5S）-2-氧代-3- [2-氟-4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷的前药衍生物 -5-基}甲基）噻吩-2-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 血栓栓塞性疾病
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公开(公告)号：US20070066615A1
公开(公告)日：2007-03-22
申请号：US10557168
申请日：2004-05-06
申请人： Christoph Gerdes , Elisabeth Perzborn , Jens Pohlmann , Susanne Rohrig , Alexander Straub , Christian Thomas , Arounarith Tuch , Karl-Heinz Schlemmer
发明人： Christoph Gerdes , Elisabeth Perzborn , Jens Pohlmann , Susanne Rohrig , Alexander Straub , Christian Thomas , Arounarith Tuch , Karl-Heinz Schlemmer
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501
CPC分类号： C07D413/14 , C07D419/14
摘要： The present invention relates to the area of blood clotting. The invention relates in particular to certain heterocyclic compounds, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及血液凝固的面积。 本发明特别涉及某些杂环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途。
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公开(公告)号：US20100048548A1
公开(公告)日：2010-02-25
申请号：US11919020
申请日：2006-04-08
IPC分类号： A61K31/422 , C12N5/00 , A61K31/5377 , A61K31/506 , A61K31/445 , A61K31/44 , C07D413/14 , C07D413/10 , A61P7/00 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to novel iminooxazolidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译： 本发明涉及新的亚氨基恶唑烷，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞障碍的药物的用途。
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公开(公告)号：US20090306139A1
公开(公告)日：2009-12-10
申请号：US12323454
申请日：2008-11-25
申请人： Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
发明人： Dirk Heimbach , Susanne Rohrig , Dirk Schneider , Ulrich Rester , Eckhard Bender , Mark Meininghaus , Katja Zimmermann , Dmitry Zubov , Anja Buchmuller , Georges Von Degenfeld , Christoph Gerdes , Michael Gerisch , Mark Jean Gnoth , Yolanda Cancho Grande , Mario Jeske , Kersten Matthias Gericke
IPC分类号： A61K31/454 , C07D401/14 , A61P7/02
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular diseases and tumour diseases.
摘要翻译： 本发明涉及新颖的杂芳基取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途 和肿瘤疾病。
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公开(公告)号：US20120220563A1
公开(公告)日：2012-08-30
申请号：US13321966
申请日：2010-05-19
申请人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
发明人： Dirk Heimbach , Susanne Röhrig , Yolanda Cancho Grande , Eckhard Bender , Katja Zimmermann , Anja Buchmüller , Christoph Gerdes , Mark Jean Gnoth , Kersten Matthias Gericke , Mario Jeske
IPC分类号： A61K31/454 , A61K31/5377 , A61K31/4545 , C07D417/14 , A01N1/02 , C07D413/04 , A61P7/02 , A61P9/00 , A61P35/00 , C07D413/14 , A61K31/541
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention relates to novel substituted piperidines, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新型取代的哌啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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