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1.发明申请公开(公告)号：US20110318726A1
公开(公告)日：2011-12-29
申请号：US13255568
申请日：2010-03-10
申请人： Svati H. Shah , Christopher B. Newgard , William E. Kraus , Elizabeth R. Hauser , Geoffrey S. Ginsburg , L. Kristin Newby
发明人： Svati H. Shah , Christopher B. Newgard , William E. Kraus , Elizabeth R. Hauser , Geoffrey S. Ginsburg , L. Kristin Newby
CPC分类号： G01N33/6887 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/4866 , A61B5/7275 , G01N21/78 , G01N2021/7786 , G01N2800/324 , G01N2800/50 , G16H50/30 , H01J49/0027 , Y10T436/174614 , Y10T436/200833 , Y10T436/201666
摘要： Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
摘要翻译： 本文公开了通过检测来自受试者的样品中至少一种代谢物的水平来评估受试者心血管疾病风险的方法。 代谢物的水平表明受试者心血管疾病的风险。 代谢物可以是酰基肉碱，氨基酸，酮类，游离脂肪酸或羟基丁酸酯。 心血管疾病可能是心血管事件，冠状动脉疾病的存在或冠状动脉疾病发展的风险。
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2.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US07790390B2
公开(公告)日：2010-09-07
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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3.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US08097415B2
公开(公告)日：2012-01-17
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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4.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20090087844A1
公开(公告)日：2009-04-02
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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公开(公告)号：US20130017962A1
公开(公告)日：2013-01-17
申请号：US12874635
申请日：2010-09-02
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68 , G01N27/447 , C40B30/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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6.发明申请ACID CERAMIDASE POLYMORPHISMS AND METHODS OF PREDICTING TRAITS USING THE ACID CERAMIDASE POLYMORPHISMS 有权酸性陶瓷多聚体和使用酸性陶瓷多糖预测路线的方法公开(公告)号：US20120065080A1
公开(公告)日：2012-03-15
申请号：US13318768
申请日：2010-05-03
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/156
摘要： Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.
摘要翻译： 提供了预测受试者中的性状的方法，包括获得关于受试者的多核苷酸序列的至少一部分的信息，编码酸性神经酰胺酶多肽的多核苷酸序列，并使用该信息来预测受试者中性状的表达。 还提供了针对具有对运动作出反应的疾病或病症的受试者制定治疗计划的方法。 所述方法可以包括使用所述信息来预测选自维持运动程序的特征和对运动程序的生理反应性的关于受试者的多核苷酸序列的至少一部分，编码酸性神经酰胺糖苷酶多肽的多核苷酸序列的信息，以及 制定治疗计划以治疗疾病或病症。
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7.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20110171630A1
公开(公告)日：2011-07-14
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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8.发明授权公开(公告)号：US07807465B2
公开(公告)日：2010-10-05
申请号：US11260842
申请日：2005-10-27
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon S. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon S. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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9.发明授权Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms 有权酸性神经酰胺酶多态性和使用酸性神经酰胺酶多态性预测性状的方法公开(公告)号：US09309572B2
公开(公告)日：2016-04-12
申请号：US13318768
申请日：2010-05-03
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/156
摘要： Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, and using the information to predict the expression of the trait in the subject. Further provided are methods of developing a treatment plan for a subject with a disease or condition responsive to exercise. The methods may include obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the acid ceramidase polypeptide, using the information to predict a trait selected from maintaining an exercise program and physiological responsiveness to an exercise program, and developing a treatment plan for the subject to treat the disease or condition.
摘要翻译： 提供了预测受试者中的性状的方法，包括获得关于受试者的多核苷酸序列的至少一部分的信息，编码酸性神经酰胺酶多肽的多核苷酸序列，并使用该信息来预测受试者中性状的表达。 还提供了针对具有对运动作出反应的疾病或病症的受试者制定治疗计划的方法。 所述方法可以包括使用所述信息来预测选自维持运动程序的特征和对运动程序的生理反应性的关于受试者的多核苷酸序列的至少一部分，编码酸性神经酰胺糖苷酶多肽的多核苷酸序列的信息，以及 制定治疗计划以治疗疾病或病症。
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10.发明申请Methods and Compositions for Correlating Genetic Markers with Cardiovascular Disease 审中-公开将遗传标记与心血管疾病相关的方法和组合公开(公告)号：US20130324416A1
公开(公告)日：2013-12-05
申请号：US13351042
申请日：2012-01-16
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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