摘要:
Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要:
Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要:
Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).
摘要:
Disclosed are compounds of the general formula (I), where the definition of the substituents A, B, D, E, R1 and R2 are detailed in the description, and the physiologically tolerated salts thereof, a process for the preparation of these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2)
摘要:
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
摘要:
The present invention relates to imidazopyridin-2-one derivatives of the formula I with the definitions specified in the description, to their pharmaceutically usable salts and to their use as medicaments.
摘要:
The invention relates to a strain of the yeast Saccharomyces cerevisiae which, owing to deletion of the genomic sequences, no longer synthesizes hexose transporters and, as a consequence, can no longer grow on substrates with hexoses as the only carbon source, and whose ability of growing on a substrate with a hexose as the only carbon source is restored when it expresses a GLUT4 gene.
摘要:
A device is disclosed for trapping mosquitoes. The device includes a housing, a bag and a fan located in the housing. The fan creates capture zone with an air flow towards the bag. A plurality of light sources attract mosquitoes to the capture zone. The light sources include an ultraviolet light, a plurality of light emitting diodes, and an incandescent light. A heat source also attracts the mosquitoes to the capture zone.
摘要:
To permit greater through-put of a mold box filling and compacting system, mold boxes are moved vertically by a lifting table which passes through the station transport turret (10) to place a pattern or mold carrier plate (11, 12) in the mold box, and, upon continued vertical movement, placing a filling frame (14) about the mold box, and, upon further vertical movement, placing the thus formed subassembly in engagement with a sand filling apparatus (15). Upon subsequent lowering, the subassembly is returned to the turret, the turret rotates and places the subassembly in position for alignment with a compacting station, raises the subassembly to the compacting station for compaction of the sand about the model or pattern. The subassembly is then lowered; after lowering for a short distance, the fill pattern transport, for example another turret or pivotable arm system, is placed in interfering position with the filling frame so that it is stripped off the mold box which is then lowered on a removal conveyor, for removal from the compacting station; continued downward movement at the compacting station table then places the now freed pattern or model carrier plate again on the station transport turret for return to the first position. Sand filling and compaction can be carried out simultaneously on sequentially arriving mold boxes under control of a control system (C) which controls appropriate sequencing.