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    MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY
    4.
    发明申请
    MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY 审中-公开
    MAYTANSINOIDS和使用抗抑郁剂预防并发症的药物

    公开(公告)号：US20120276124A1

    公开(公告)日：2012-11-01

    申请号：US13434363

    申请日：2012-03-29

    申请人： Hervé BOUCHARD ,  Alain COMMERCON ,  Claudia FROMOND ,  Vincent MIKOL ,  Fabienne PARKER ,  Ingrid SASSOON ,  Daniel TAVARES

    发明人： Hervé BOUCHARD ,  Alain COMMERCON ,  Claudia FROMOND ,  Vincent MIKOL ,  Fabienne PARKER ,  Ingrid SASSOON ,  Daniel TAVARES

    IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K17/02 ,  A61K31/537 ,  C07D498/18 ,  C07K1/04

    CPC分类号： C07D498/18 ,  A61K47/6803 ,  A61K47/6849

    摘要： The invention relates to a compound of formula (I): wherein: ALK is a (C1-C6)alkylene group; X1 et X2 are each independently one of the following groups: —CH═CH—, —CO—, —CONR—, —NRCO—, —COO—, —OCO—, —OCONR—, —NRCOO—, —NRCONR′—, —NR—, —S(O)n (n=0, 1 or 2) or —O—; R and R′ are independently H or a (C1-C6)alkyl group; i is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; j is an integer corresponding to 1 when X2 is —CH═CH— and 2 when X2 is not —CH═CH—; Zb is a simple bond, —O— or —NH— and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal.

    摘要翻译： 本发明涉及式（I）化合物：其中：ALK是（C1-C6）亚烷基; X1和X2各自独立地为以下基团之一：-CH = CH - ， - CO - ， - CONR - ， - NRCO - ， - COO-， - OCO-， - OCONR - ， - NRCOO-，-NRCONR'- ，-NR - ， - S（O）n（n = 0,1或2）或-O-; R和R'独立地为H或（C 1 -C 6）烷基; i为1〜40的整数，优选为1〜20，更优选为1〜10; 当X2是-CH = CH-时，j是对应于1的整数，当X2不是-CH = CH-时，j是2; Zb是单键，-O-或-NH-，Rb是H或（C 1 -C 6）烷基，（C 3 -C 7）环烷基，芳基，杂芳基或（C 3 -C 7）杂环烷基; 或Zb为单键，Rb为Hal。