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公开(公告)号:US5627203A
公开(公告)日:1997-05-06
申请号:US576678
申请日:1995-12-21
申请人: Sylvain Rault , Max Robba , Jean-Charles Lancelot , Herv e Prunier , Pierre Renard , Bruno Pfeiffer , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
发明人: Sylvain Rault , Max Robba , Jean-Charles Lancelot , Herv e Prunier , Pierre Renard , Bruno Pfeiffer , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
IPC分类号: A61K31/00 , A61K31/40 , A61K31/407 , A61K31/445 , A61K31/535 , A61P1/00 , A61P1/08 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P25/32 , A61P43/00 , C07D487/04 , C07D495/14 , C07D513/14
CPC分类号: C07D487/04 , C07D495/14
摘要: The present invention relates to compounds of formula (I): ##STR1## wherein A, x, y, R.sub.1, R.sub.2 and R.sub.3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site and 5-HT.sub.2c or 5-HT.sub.3 ligand.
摘要翻译: 本发明涉及式(I)的化合物:其中A,x,y,R 1,R 2和R 3如说明书中所定义。 该化合物可用于治疗需要选择性5-羟色胺再摄取位点和5-HT2c或5-HT3配体的疾病。
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公开(公告)号:US5569669A
公开(公告)日:1996-10-29
申请号:US401768
申请日:1995-03-10
申请人: G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
发明人: G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
IPC分类号: A61K31/335 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/382 , A61K31/39 , A61K31/47 , A61K31/472 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C217/14 , C07C217/60 , C07C217/62 , C07D215/24 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D307/79 , C07D311/04 , C07D311/58 , C07D317/64 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08
CPC分类号: C07D307/79 , C07C217/60 , C07C217/62 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D311/58 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08 , C07C2102/08
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.2', R.sub.2", R.sub.2'", R.sub.3 and n are as defined in the description, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same useful for treating a mammal afflicted with a disorder associated to 5-HT.sub.1A or 5-HT.sub.2C receptors.
摘要翻译: 本发明涉及一种选自式(I)的化合物:其中R1,R2,R2',R2“,R2”',R3和n如说明书中所定义, 光学异构体及其与药学上可接受的酸或碱的加成盐,以及含有可用于治疗患有与5-HT1A或5-HT2C受体相关的病症的哺乳动物的药物。
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公开(公告)号:US5616614A
公开(公告)日:1997-04-01
申请号:US377812
申请日:1995-01-25
申请人: Said Yous , Daniel Lesieur , Patrick Depreux , B eatrice Guardiola-Lemaitre , G erard Adam , Pierre Renard , Daniel H. Caignard
发明人: Said Yous , Daniel Lesieur , Patrick Depreux , B eatrice Guardiola-Lemaitre , G erard Adam , Pierre Renard , Daniel H. Caignard
IPC分类号: A61K31/135 , A61K31/16 , A61K31/215 , A61P17/00 , A61P25/00 , A61P37/00 , A61P43/00 , C07C233/05 , C07C233/58 , C07C233/60 , C07C233/63 , C07C275/24 , C07D295/10 , C07C229/26
CPC分类号: C07C233/63 , C07C233/05 , C07C233/58 , C07C233/60 , C07C275/24 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要: The invention relates to a compound selected from those of general formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable base. Medicinal product which is useful in the treatment of disorders linked to abnormal melatonin activity.
摘要翻译: 本发明涉及选自通式(I)的化合物:其中R,R 1,R 2和R 3如本说明书中所定义的其中R 1,R 2和R 3如本文所定义的光学异构体及其加成盐与药学上 可接受的基地 可用于治疗与异常褪黑素活性相关的疾病的药用产品。
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