公开(公告)号：US20190127324A1

公开(公告)日：2019-05-02

申请号：US16200178

申请日：2018-11-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/48 ,  C07D401/12 ,  C07D207/30 ,  C07D207/36

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US11498898B2

公开(公告)日：2022-11-15

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20210070705A1

公开(公告)日：2021-03-11

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Misayo Sera ,  Naohiro Fukuda ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US10173977B2

公开(公告)日：2019-01-08

申请号：US14994360

申请日：2016-01-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20230088365A1

公开(公告)日：2023-03-23

申请号：US17961978

申请日：2022-10-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tomomi Ikemoto ,  Misayo Sera ,  Naohiro Fukuda ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20180009746A1

公开(公告)日：2018-01-11

申请号：US14994360

申请日：2016-01-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/48 ,  C07D207/34 ,  C07C225/14 ,  C07D207/333 ,  C07D207/30 ,  C07D401/12 ,  C07D207/36

CPC classification number: C07D207/337 ,  C07D207/30 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D207/48 ,  C07D401/12

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.