公开(公告)号：US20190127324A1

公开(公告)日：2019-05-02

申请号：US16200178

申请日：2018-11-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/48 ,  C07D401/12 ,  C07D207/30 ,  C07D207/36

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US09266831B2

公开(公告)日：2016-02-23

申请号：US14303238

申请日：2014-06-12

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Toshiaki Nagata ,  Naohiro Fukuda

IPC: C07D207/34 ,  C07D207/337 ,  C07D207/333 ,  C07D207/36 ,  C07D401/12 ,  C07C225/14 ,  C07D207/30 ,  C07D207/48

CPC classification number: C07D207/337 ,  C07D207/30 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D207/48 ,  C07D401/12

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

Abstract translation: 本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。 本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ）， 并使化合物（VI）进行胺化反应。

公开(公告)号：US10538489B2

公开(公告)日：2020-01-21

申请号：US16200178

申请日：2018-11-26

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Naohiro Fukuda

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US10174004B2

公开(公告)日：2019-01-08

申请号：US14768784

申请日：2014-02-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Naohiro Fukuda ,  Tomomi Ikemoto

IPC: C07D403/04 ,  C07D231/12 ,  C07D403/10

Abstract: The present invention provides an industrially advantageous method of producing a pyridazinone compound. The present invention relates to the following method of producing a pyridazinone compound: Formula (II), (IIIa), (IV) or (IV″), Formula (IIIb), (Vb) or (V″b), Formula (VI), (I) or (I″), wherein each symbol is as described in the specification.

公开(公告)号：US11498898B2

公开(公告)日：2022-11-15

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20210070705A1

公开(公告)日：2021-03-11

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Misayo Sera ,  Naohiro Fukuda ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US10173977B2

公开(公告)日：2019-01-08

申请号：US14994360

申请日：2016-01-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20230088365A1

公开(公告)日：2023-03-23

申请号：US17961978

申请日：2022-10-07

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tomomi Ikemoto ,  Misayo Sera ,  Naohiro Fukuda ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20180009746A1

公开(公告)日：2018-01-11

申请号：US14994360

申请日：2016-01-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/48 ,  C07D207/34 ,  C07C225/14 ,  C07D207/333 ,  C07D207/30 ,  C07D401/12 ,  C07D207/36

CPC classification number: C07D207/337 ,  C07D207/30 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D207/48 ,  C07D401/12

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.