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    DEVICES AND METHODS FOR SAMPLE DISSOCIATION AND MANIPULATION IN A MICROFLUIDIC SYSTEM
    2.
    发明公开
    DEVICES AND METHODS FOR SAMPLE DISSOCIATION AND MANIPULATION IN A MICROFLUIDIC SYSTEM 审中-公开

    公开(公告)号：US20240335837A1

    公开(公告)日：2024-10-10

    申请号：US18605476

    申请日：2024-03-14

    Applicant: TDK U.S.A. Corporation

    Inventor： Manish Giri ,  Rakesh Sethi ,  Vadim Piskun

    IPC: B01L3/00

    CPC classification number: B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0663 ,  B01L2300/0864 ,  B01L2400/0436 ,  B01L2400/0496

    Abstract: A microfluidic device and a method for dissociating and manipulating cells or particles in a microfluidic channel are disclosed. The microfluidic device includes an inlet, an outlet, and a microfluidic channel arranged on a substrate between the inlet and the outlet. The microfluidic device includes a first set of piezoelectric actuators arranged adjacent to the inlet channel and configured to dissociate particles of a fluidic sample in the microfluidic channel. The microfluidic device includes a second set of piezoelectric actuators arranged between the inlet channel and the outlet channel and configured to manipulate the particles of the fluidic sample as the particles move through the microfluidic channel. The microfluidic device includes a third set of piezoelectric actuators arranged above the outlet channel, adjacent to the outlet, and configured to eject a portion of the fluidic sample out of the microfluidic channel via the outlet.

    System and Method for Clustering and Deconvolution of Particle Phenotype
    3.
    发明申请
    System and Method for Clustering and Deconvolution of Particle Phenotype 有权

    公开(公告)号：US20240426730A1

    公开(公告)日：2024-12-26

    申请号：US18746011

    申请日：2024-06-17

    Applicant: TDK U.S.A. Corporation

    Inventor： Rakesh Sethi

    IPC: G01N15/02 ,  G01N15/10 ,  G01N15/12

    Abstract: A system for classifying individual particles includes a microfluidic device and an electronic device. The microfluidic device includes a microfluidic channel arranged on a first substrate, an optical or magnetic sensing zone arranged along a first portion of the microfluidic channel, and an electrical sensing zone arranged along a second portion of the microfluidic channel. The system obtains a plurality of impedance values corresponding to a plurality of sample particles of a target sample, and inputs the plurality of impedance values into a first target particle classification model. The system applies, locally in the electronic device, the first target particle classification model to the plurality of impedance values to determine a respective particle type classification for each particle of the plurality of sample particles.

    Systems, Methods, and Devices for Haptic Feedback
    4.
    发明公开
    Systems, Methods, and Devices for Haptic Feedback 审中-公开

    公开(公告)号：US20240029528A1

    公开(公告)日：2024-01-25

    申请号：US17869078

    申请日：2022-07-20

    Applicant: TDK U.S.A. Corporation

    Inventor： Rakesh Sethi

    IPC: G08B6/00

    CPC classification number: G08B6/00

    Abstract: Systems, methods, and devices for haptic feedback are provided. A microfluidic device includes an inlet port for supplying a fluid into the microfluidic device. A tube receives the fluid from the inlet port. The microfluidic device includes a piezoelectric actuator for realizing a displacement of a substrate to which the microfluidic device is attached, the displacement based on an electrical actuation applied to the piezoelectric actuator, and an amount of the fluid or a pressure in the tube. In some embodiments, the tube includes a carbon nanotube. In some embodiments, an amount of the fluid in the tube is controlled by an actuator (e.g., the piezoelectric actuator).

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