公开(公告)号：US20230256444A1

公开(公告)日：2023-08-17

申请号：US18138911

申请日：2023-04-25

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Tin Ngo ,  Jennifer Ji ,  Marta Matvienko ,  Tiffany Ding (Lay)

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502792 ,  B01L2300/123 ,  B01L2400/0427

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.

公开(公告)号：US11951482B2

公开(公告)日：2024-04-09

申请号：US17559362

申请日：2021-12-22

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

CPC classification number: B01L3/502792 ,  B01L2400/0427

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US11666914B2

公开(公告)日：2023-06-06

申请号：US15975283

申请日：2018-05-09

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Tin Ngo ,  Jennifer Ji ,  Marta Matvienko ,  Tiffany Ding (Lay)

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502792 ,  B01L2300/123 ,  B01L2400/0427

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.

公开(公告)号：US20190331638A1

公开(公告)日：2019-10-31

申请号：US15962925

申请日：2018-04-25

Applicant: Tecan Trading AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tin Ngo ,  Tiffany Ding (Lay) ,  Torleif Ove Bjornson

IPC: G01N27/447 ,  B01L3/00

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

公开(公告)号：US20190329258A1

公开(公告)日：2019-10-31

申请号：US15962892

申请日：2018-04-25

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US12115532B2

公开(公告)日：2024-10-15

申请号：US18138911

申请日：2023-04-25

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Tin Ngo ,  Jennifer Ji ,  Marta Matvienko ,  Tiffany Ding (Lay)

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502792 ,  B01L2300/123 ,  B01L2400/0427

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge contains an internal gap with at least one hydrophobic surface for enabling an electrowetting induced movement of a microfluidic droplet that has magnetic beads and further has a bead accumulation zone, into which the microfluidic droplet is transferable by electrowetting force and the magnetic beads are exposable to a magnetic force of a bead manipulation magnet. The internal gap has a bead extraction opening adjacent to the bead accumulation zone. The bead extraction opening provides a passage from the gap to an exterior space of the cartridge and is configured to removably receive the bead manipulation magnet for enabling an extraction of the magnetic beads from the microfluidic droplet by a removal of the bead manipulation magnet.

公开(公告)号：US11933760B2

公开(公告)日：2024-03-19

申请号：US17901634

申请日：2022-09-01

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tin Ngo ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tiffany Ding (Lay)

IPC: G01N27/447 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  G01N27/44739 ,  G01N27/44747 ,  B01L2200/027 ,  B01L2300/161 ,  B01L2400/0427

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.

公开(公告)号：US20220111388A1

公开(公告)日：2022-04-14

申请号：US17559362

申请日：2021-12-22

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US12290804B2

公开(公告)日：2025-05-06

申请号：US17294853

申请日：2018-12-20

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Philipp Ott ,  Adrian Sager

IPC: B01L3/02 ,  C12Q1/6806 ,  G01N1/28 ,  G01N1/30 ,  G01N35/10 ,  G01N1/31

Abstract: A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.

公开(公告)号：US11992833B2

公开(公告)日：2024-05-28

申请号：US17295624

申请日：2019-12-20

Applicant: TECAN TRADING AG

Inventor： Adrian Sager ,  Philipp Ott ,  Patrick Kinney ,  Hagen Reinhardt ,  Michael Keller ,  Sujata Iyer

IPC: G01N35/10 ,  B01L3/00 ,  B01L3/02 ,  B03C1/01 ,  B03C1/32

CPC classification number: B01L3/0275 ,  B01L3/0279 ,  B03C1/01 ,  B03C1/32 ,  G01N35/10 ,  B01L3/0217 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0832 ,  B01L2300/0858 ,  B01L2300/18 ,  B01L2400/0478 ,  G01N2035/103

Abstract: A pipette tip extension attachable to a pipette tip having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip, and at the distal end a dispense aperture. The pipette tip extension further has an inner cavity, a distance element connected to the inner side of the exterior wall, and a constriction element.