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公开(公告)号：US20190284252A1
公开(公告)日：2019-09-19
申请号：US16356872
申请日：2019-03-18
发明人： Suresh Kumar Thallapuranam , Shilpi Agarwal , Ravi Kumar Gindampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
摘要： Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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公开(公告)号：US20180229299A1
公开(公告)日：2018-08-16
申请号：US15896595
申请日：2018-02-14
发明人： Cameron Crane , Jingyi Chen , Feng Wang
IPC分类号： B22F1/02 , B01J23/72 , B01J21/08 , B01J35/00 , B01J37/02 , C10M125/04 , C10M125/26 , A61K41/00 , A61K49/00 , A01N25/28 , A01N59/20 , G01N21/552 , G01N21/65 , B22F1/00
CPC分类号： B22F1/02 , A01N25/28 , A01N59/20 , A61K41/0052 , A61K49/0002 , B01J21/08 , B01J23/72 , B01J35/0006 , B01J35/0013 , B01J35/008 , B01J35/023 , B01J35/026 , B01J35/08 , B01J37/0211 , B01J37/0221 , B22F1/0018 , B22F1/0025 , B22F1/0062 , B22F2001/0037 , B22F2301/10 , B22F2302/256 , B22F2304/054 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C10M125/04 , C10M125/26 , C10M2201/05 , C10M2201/105 , C10N2210/01 , C10N2220/082 , G01N21/554 , G01N21/658 , Y10S977/773 , Y10S977/81 , Y10S977/892 , Y10S977/915 , Y10S977/927 , Y10S977/954
摘要： In one aspect, compositions comprising copper-silica (Cu—SiO2) core-shell nanoparticles are described herein. The core-shell nanoparticles comprise copper (Cu) core components and silica (SiO2) shell components encapsulating the core components. In some embodiments, the nanoparticle compositions comprise a continuous aqueous phase and a population of copper-silica (Cu—SiO2) core-shell nanoparticles dispersed in the aqueous phase.
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公开(公告)号：US11655552B2
公开(公告)日：2023-05-23
申请号：US16818249
申请日：2020-03-13
IPC分类号： C25B11/091 , C25B11/051
CPC分类号： C25B11/091 , C25B11/051
摘要： In an aspect, a method of making a composite core-shell nanoparticle comprises forming a nanoparticle core comprising nickel oxide or iron oxide via thermal decomposition of a nickel complex or an iron complex; and forming an oxide shell over the core, the oxide shell comprising nickel, iron or a mixture thereof. In another aspect, a method of making composite nanoparticles comprises providing a mixture comprising nickel complex and iron complex; and thermally decomposing the nickel and iron complexes to provide the composite nanoparticles comprising (Ni,Fe)Ox alloy. In yet another aspect, a composition comprises composite nanoparticles, the composite nanoparticles including a nickel oxide core and oxide shell, the oxide shell comprising a mixture of nickel and iron.
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公开(公告)号：US20220227826A1
公开(公告)日：2022-07-21
申请号：US17587889
申请日：2022-01-28
发明人： Suresh Kumar Thallapuranam , Shilpi Agrawal , Ravi Kumar Gundampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
摘要： Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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公开(公告)号：US11267855B2
公开(公告)日：2022-03-08
申请号：US16356872
申请日：2019-03-18
发明人： Suresh Kumar Thallapuranam , Shilpi Agarwal , Ravi Kumar Gundampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
摘要： Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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