公开(公告)号：US20150265673A1

公开(公告)日：2015-09-24

申请号：US14731852

申请日：2015-06-05

Applicant: The Regents of the University of California ,  United States Government Represented by The Department of Veterans Affairs

Inventor： Samuel S. Murray ,  Elsa J. Brochmann-Murray ,  Keyvan Behnam ,  Jeffrey C. Wang

IPC: A61K38/12 ,  A61K35/12 ,  A61K35/32 ,  C07K7/64

CPC classification number: A61K38/12 ,  A61K35/12 ,  A61K35/32 ,  A61K38/10 ,  A61K38/1841 ,  A61K38/1875 ,  C07K7/64 ,  C07K14/47 ,  C07K14/51 ,  A61K2300/00

Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.

Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。

公开(公告)号：US09050300B2

公开(公告)日：2015-06-09

申请号：US13857711

申请日：2013-04-05

Applicant: The Regents of the University of California ,  The United States of America, Represented by the Department of Veterans Affairs

Inventor： Samuel S. Murray ,  Elsa J. Brochmann-Murray ,  Keyvan Behnam ,  Jeffrey C. Wang

IPC: A61K38/18 ,  A61K38/10 ,  A61K35/32 ,  C07K4/12 ,  C07K14/495 ,  C07K14/51

CPC classification number: A61K38/12 ,  A61K35/12 ,  A61K35/32 ,  A61K38/10 ,  A61K38/1841 ,  A61K38/1875 ,  C07K7/64 ,  C07K14/47 ,  C07K14/51 ,  A61K2300/00

Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.

Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。

公开(公告)号：US09610320B2

公开(公告)日：2017-04-04

申请号：US14731852

申请日：2015-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Samuel S. Murray ,  Elsa J. Brochmann-Murray ,  Keyvan Behnam ,  Jeffrey C. Wang

IPC: A61K38/12 ,  A61K35/12 ,  A61K35/32 ,  C07K7/64 ,  A61K38/18 ,  C07K14/51 ,  A61K38/10 ,  C07K14/47

CPC classification number: A61K38/12 ,  A61K35/12 ,  A61K35/32 ,  A61K38/10 ,  A61K38/1841 ,  A61K38/1875 ,  C07K7/64 ,  C07K14/47 ,  C07K14/51 ,  A61K2300/00

Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.