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公开(公告)号：US20150246158A1
公开(公告)日：2015-09-03
申请号：US14640451
申请日：2015-03-06
Inventor： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
CPC classification number: A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Abstract translation: 称为BMP结合肽（BBP）的环化肽是与内生形式的BBP一样强烈地结合rhBMP-2的合成肽，并且物种之间的序列保守性导致各种有用的BBP组合物。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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公开(公告)号：US09333237B2
公开(公告)日：2016-05-10
申请号：US14263080
申请日：2014-04-28
Applicant: The Regents of The University of California , The United States of America Represented by The Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Murray , Keyvan Behnam
CPC classification number: A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Abstract translation: 称为BMP结合肽（BBP）的环化肽是一种合适的肽，其能够强烈地结合rhBMP-2。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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公开(公告)号：US20160000860A1
公开(公告)日：2016-01-07
申请号：US14755408
申请日：2015-06-30
Applicant: The Regents of the University of California , United States Government Represented by the Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Murray , Jeffrey Wang , Keyvan Behnam
CPC classification number: A61K38/12 , A61K38/08 , A61K38/10 , A61K38/1841 , A61K38/1875 , A61K2300/00
Abstract: The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical comorbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.
Abstract translation: 在美国每年进行的150万次骨移植手术中，使用自体骨移植是目前的黄金标准。 尽管这种做法导致融合率高，但与手术时间和失血量相关，伴随着供体位点发病率的显着程度。 另外，在某些情况下，例如修订案例，多层次结构，或在具有医学合并症的患者中，自体骨移植可能存在数量有限和质量上的问题。 对于自体骨移植物的合适替代物的这种显着需要刺激了对骨移植物替代物和增量剂的探索的极大兴趣。
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Patent Agency Ranking
公开(公告)号：US09855368B2
公开(公告)日：2018-01-02
申请号：US14640451
申请日：2015-03-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
IPC: A61L27/22 , C12N5/0775 , A61K35/28 , A61K38/12 , A61K38/18 , C07K14/51 , C07K7/08 , A61L27/38 , A61L27/54
CPC classification number: A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
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公开(公告)号：US20150265673A1
公开(公告)日：2015-09-24
申请号：US14731852
申请日：2015-06-05
Applicant: The Regents of the University of California , United States Government Represented by The Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。
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公开(公告)号：US09050300B2
公开(公告)日：2015-06-09
申请号：US13857711
申请日：2013-04-05
Applicant: The Regents of the University of California , The United States of America, Represented by the Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。
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公开(公告)号：US09610320B2
公开(公告)日：2017-04-04
申请号：US14731852
申请日：2015-06-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
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公开(公告)号：US20150056700A1
公开(公告)日：2015-02-26
申请号：US14263080
申请日：2014-04-28
Applicant: The Regents of The University of California , United States Government Represented by The Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Murray , Keyvan Behnam
CPC classification number: A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the overall osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Abstract translation: 称为BMP结合肽（BBP）的环化肽是一种合适的肽，其能够强烈地结合rhBMP-2。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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