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公开(公告)号：US20150246158A1
公开(公告)日：2015-09-03
申请号：US14640451
申请日：2015-03-06
Inventor： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
CPC classification number: A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
Abstract translation: 称为BMP结合肽（BBP）的环化肽是与内生形式的BBP一样强烈地结合rhBMP-2的合成肽，并且物种之间的序列保守性导致各种有用的BBP组合物。 BBP增加rhBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。 包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。
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公开(公告)号：US09610320B2
公开(公告)日：2017-04-04
申请号：US14731852
申请日：2015-06-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
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公开(公告)号：US09855368B2
公开(公告)日：2018-01-02
申请号：US14640451
申请日：2015-03-06
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Samuel S. Murray , Elsa J. Murray , Jeffrey C. Wang , Keyvan Behnam
IPC: A61L27/22 , C12N5/0775 , A61K35/28 , A61K38/12 , A61K38/18 , C07K14/51 , C07K7/08 , A61L27/38 , A61L27/54
CPC classification number: A61L27/227 , A61K35/28 , A61K38/12 , A61K38/1841 , A61K38/1875 , A61L27/3821 , A61L27/3834 , A61L27/54 , A61L2400/18 , A61L2430/02 , C07K7/08 , C07K14/51 , C12N5/0668 , C12N2501/15 , C12N2501/155 , A61K2300/00
Abstract: A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
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Patent Agency Ranking
公开(公告)号：US20150265673A1
公开(公告)日：2015-09-24
申请号：US14731852
申请日：2015-06-05
Applicant: The Regents of the University of California , United States Government Represented by The Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。
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公开(公告)号：US09050300B2
公开(公告)日：2015-06-09
申请号：US13857711
申请日：2013-04-05
Applicant: The Regents of the University of California , The United States of America, Represented by the Department of Veterans Affairs
Inventor： Samuel S. Murray , Elsa J. Brochmann-Murray , Keyvan Behnam , Jeffrey C. Wang
CPC classification number: A61K38/12 , A61K35/12 , A61K35/32 , A61K38/10 , A61K38/1841 , A61K38/1875 , C07K7/64 , C07K14/47 , C07K14/51 , A61K2300/00
Abstract: The present invention relates to the clinical application of BBP, alone or in combination with other growth factors, for use in bone healing applications, such as spinal surgery. Additional applications include use in orthopedic implantable prostheses and implantation into other surgical sites (e.g., surgical reconstruction, regional osteopenia, etc.) where bone is desired.
Abstract translation: 本发明涉及BBP的单独使用或与其它生长因子组合用于骨愈合应用如脊柱外科手术中的临床应用。 另外的应用包括在矫形植入式假体中使用并植入其中需要骨骼的其它手术部位（例如手术重建，区域性骨量减少等）。
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公开(公告)号：US20200323786A1
公开(公告)日：2020-10-15
申请号：US16304116
申请日：2017-05-24
Applicant: The Regents of the University of California , THE UNIVERSITY OF SOUTHERN CALIFORNIA , TIANJIN UNIVERSITY
Inventor： Yunfeng Lu , Jeffrey C. Wang , Haijun Tian , Juanjuan Du , Jing Wen , Yang Liu , Xubo Yuan
Abstract: Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited in by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.
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公开(公告)号：US20150305914A1
公开(公告)日：2015-10-29
申请号：US14700459
申请日：2015-04-30
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Benjamin M. Wu , Jeffrey C. Wang , Emily W. Loughran
CPC classification number: A61F5/05841 , A61F5/01 , A61F13/041 , A61F13/046 , A61F2240/00 , A61L15/12
Abstract: A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking.
Abstract translation: 用于固定患者的身体构件的多层铸件包括具有被配置为施加在主体构件上并基本上符合本体构件的形状的形状的疏水套管，以及构造成围绕所述套筒定位的可模制层 并且被硬化以符合邻近所述套筒的所述本体构件的形状。 疏水套管包括被配置为将湿气向外远离本体构件的纤维，并且可模塑层包括延伸穿过可模制层的孔网，使得孔构造成接触疏水套管以促进水分从疏水性 通过可成型层向外套。 外部可去除的包装也可以可拆卸地设置在可模制层周围以用于额外的支撑和湿气芯吸。
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公开(公告)号：US20140178346A1
公开(公告)日：2014-06-26
申请号：US14140420
申请日：2013-12-24
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： James A. Byrne , Jeffrey C. Wang
IPC: A61K35/32
CPC classification number: A61K35/32 , A61K35/12 , A61K35/33 , A61K35/35 , A61K38/1875 , A61K38/39 , A61L24/0005 , A61L24/102 , A61L27/24 , A61L27/3633 , A61L27/3804 , A61L2300/64 , A61L2400/06 , A61L2430/02 , A61L2430/38 , C12N5/0656 , C12N2510/00 , C12N2511/00 , C12N2533/54 , A61K2300/00
Abstract: Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or material forming a matrix or scaffold. In one embodiment, the population of fibroblasts is genetically engineered to secrete a therapeutic protein in an amount effective to induce tissue growth or tissue repair when the cell composition is transplanted into a subject in need thereof. For example, the therapeutic protein can be a bone morphogenic protein when the tissue to be treated is bone tissue. A preferred bone morphogenic protein is BMP-2.
Abstract translation: 提供用于组织工程的细胞组合物，其含有与组织工程基质或支架组合的自体，最少传代的真皮成纤维细胞群体或形成基质或支架的材料。 在一个实施方案中，当将细胞组合物移植到有需要的受试者中时，成纤维细胞群被遗传工程化以分泌有效诱导组织生长或组织修复的量的治疗性蛋白质。 例如，当待治疗的组织是骨组织时，治疗性蛋白质可以是骨形态发生蛋白质。 优选的骨形态发生蛋白是BMP-2。
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