公开(公告)号：US09950341B2

公开(公告)日：2018-04-24

申请号：US14567152

申请日：2014-12-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ben Wu ,  Arnold Suwarnasarn ,  Fernando Vinuela ,  Ichiro Yuki

IPC: B05D3/02 ,  B05D1/02 ,  B05D3/06

CPC classification number: B05D3/0254 ,  B05D1/02 ,  B05D3/06

Abstract: Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via an atomized polymer deposition process. The resulting device is a detachable aneurysm coil system which preserves the mechanical geometry and flexibility of the coil, and delivers specific agents to promote wound healing.

公开(公告)号：US20140180395A1

公开(公告)日：2014-06-26

申请号：US14148706

申请日：2014-01-06

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Benjamin M. Wu ,  Arnold Suwarnasarn ,  Fernando Vinuela ,  Ichiro Yuki

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61B17/12113 ,  A61B17/1215 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/00893 ,  A61L31/10 ,  A61L31/16 ,  A61L2420/02 ,  C08L67/04

Abstract: An endovascular spiral coil coating and methods of making and using the same.

Abstract translation: 血管内螺旋线圈涂层及其制造和使用方法。

公开(公告)号：US20150216684A1

公开(公告)日：2015-08-06

申请号：US14622148

申请日：2015-02-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dieter Enzmann ,  Issei Kan ,  Ichiro Yuki ,  Fernando Vinuela

IPC: A61F2/852 ,  A61F2/848

CPC classification number: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2220/0008 ,  A61F2250/0023

Abstract: A coaxial stent system is described in which an inner treatment stent is configured to be coaxially positioned inside an outer anchoring stent. The outer anchoring stent is adapted for insertion into a blood vessel and anchoring to the blood vessel at a position where the outer anchoring stent spans a neck of an aneurysm. A method for endovascular treatment of aneurysms is also described.

Abstract translation: 描述了一种同轴支架​​系统，其中内部治疗支架构造成同轴位于外部锚固支架内部。 外锚固支架适于插入血管并且在外锚定支架跨越动脉瘤颈部的位置处锚定到血管。 还描述了动脉瘤血管内治疗的方法。

公开(公告)号：US20230001043A1

公开(公告)日：2023-01-05

申请号：US17756234

申请日：2020-11-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ichiro Yuki ,  Shuichi Suzuki ,  Kousaku Ohkawa ,  Frank P.K. Hsu

IPC: A61L24/00 ,  A61L24/08 ,  A61L24/04

Abstract: A liquid embolic composition of natural polymers, water, and angiographic contrast agents improves neurovascular interventions, making them more reliable, safe, and affordable. The embolic material is made of a single component activated by blood calcium ion, which triggers coagulation, and that offers superior mechanical stability and does not cause fragmentation in the target vessel. The material retains superior long-term mechanical durability after deployment and provides sufficient visualization under fluoroscopy with iodine-based angiographic contrast compounds or other radiopaque compositions. Described herein are aqueous solutions that enable a high concentration gellan gum (greater than 0.5 wt %) to retain sol state even at the range of body temperature (30-40° C.). This discovery means that it is possible to increase the concentration of gellan gum without losing its inject-ability, yet significantly improve its mechanical stability after delivery.

公开(公告)号：US09763812B2

公开(公告)日：2017-09-19

申请号：US14622148

申请日：2015-02-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dieter Enzmann ,  Issei Kan ,  Ichiro Yuki ,  Fernando Vinuela

IPC: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2/82

CPC classification number: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2220/0008 ,  A61F2250/0023

Abstract: A coaxial stent system is described in which an inner treatment stent is configured to be coaxially positioned inside an outer anchoring stent. The outer anchoring stent is adapted for insertion into a blood vessel and anchoring to the blood vessel at a position where the outer anchoring stent spans a neck of an aneurysm. A method for endovascular treatment of aneurysms is also described.

公开(公告)号：US20150165462A1

公开(公告)日：2015-06-18

申请号：US14567152

申请日：2014-12-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ben Wu ,  Arnold Suwarnasarn ,  Fernando Vinuela ,  Ichiro Yuki

IPC: B05B12/12 ,  B05D3/02 ,  B05D3/06 ,  B05B12/02 ,  B05D1/02

CPC classification number: B05D3/0254 ,  B05D1/02 ,  B05D3/06

Abstract: Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via an atomized polymer deposition process. The resulting device is a detachable aneurysm coil system which preserves the mechanical geometry and flexibility of the coil, and delivers specific agents to promote wound healing.

Abstract translation: 用于涂覆螺旋颅内动脉瘤线圈的系统和方法，例如Guglielmi可分离线圈（GDC），使得仅沿着螺旋线圈的选定表面通过雾化聚合物沉积工艺被聚合物涂覆。 所得到的装置是可分离的动脉瘤线圈系统，其保留线圈的机械几何形状和柔性，并且递送特定的药剂以促进伤口愈合。