公开(公告)号：US12227606B2

公开(公告)日：2025-02-18

申请号：US17234304

申请日：2021-04-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Benjamin M. Wu ,  Giovanny F. Acosta-Vélez

IPC: C08F283/06 ,  B33Y80/00 ,  C09D151/08

Abstract: The present invention relates in part to a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator. The invention also relates in part to a method of making the photocurable resin composition. The invention also relates in part to a method of fabricating an article comprising the steps of providing a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator; 3D printing the photocurable resin to form an article; and curing the article. The invention also relates in part to a 3D printed resin article.

公开(公告)号：US11287426B2

公开(公告)日：2022-03-29

申请号：US15756542

申请日：2016-09-02

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/569 ,  G01N33/558 ,  G01N33/48 ,  G01N33/49 ,  G01N33/483 ,  G01N33/493

Abstract: In various embodiments devices and methods for the detection and/or quantification of clinically relevant pathogens (e.g., bacteria, fungi, viruses, etc.) are provided. In certain embodiments the device comprises a lateral-flow assay that detects the bacterium at a concentration of less than about 6×106 cells/mL, less than about 3×106 cells/ml, less than about 1×106 CFU/mL, or less than about 50 μg/mL. In certain embodiments the device comprises an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a lateral-flow assay (LFA). In certain embodiments the device comprises a flow-through system comprising a concentration component comprising an aqueous two-phase system (ATPS) comprising a mixed phase solution that separates into a first phase solution and a second phase solution; and a detection component disposed beneath said concentration component.

公开(公告)号：US10006911B2

公开(公告)日：2018-06-26

申请号：US15787638

申请日：2017-10-18

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/543 ,  G01N33/558

CPC classification number: G01N33/558 ,  G01N33/54366 ,  G01N33/54386

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

公开(公告)号：US09823247B2

公开(公告)日：2017-11-21

申请号：US14641022

申请日：2015-03-06

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/558 ,  G01N33/543

CPC classification number: G01N33/558 ,  G01N33/54366 ,  G01N33/54386

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

公开(公告)号：US10359423B2

公开(公告)日：2019-07-23

申请号：US15990398

申请日：2018-05-25

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/558 ,  G01N33/543

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

公开(公告)号：US20180100854A1

公开(公告)日：2018-04-12

申请号：US15787638

申请日：2017-10-18

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/558 ,  G01N33/543

CPC classification number: G01N33/558 ,  G01N33/54366 ,  G01N33/54386

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

公开(公告)号：US20170266440A1

公开(公告)日：2017-09-21

申请号：US15470542

申请日：2017-03-27

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Wentai Liu ,  James C.Y. Dunn ,  Benjamin M. Wu ,  Yi-Kai Lo ,  Chih-Wei Chang ,  Justin P. Wagner

IPC: A61N1/36 ,  A61N1/08

CPC classification number: A61N1/36007 ,  A61B5/4233 ,  A61B5/4238 ,  A61B5/4255 ,  A61F5/0026 ,  A61N1/0509 ,  A61N1/0517 ,  A61N1/08

Abstract: A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.

公开(公告)号：US20150305914A1

公开(公告)日：2015-10-29

申请号：US14700459

申请日：2015-04-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Benjamin M. Wu ,  Jeffrey C. Wang ,  Emily W. Loughran

IPC: A61F5/058 ,  A61L15/12

CPC classification number: A61F5/05841 ,  A61F5/01 ,  A61F13/041 ,  A61F13/046 ,  A61F2240/00 ,  A61L15/12

Abstract: A multi-layer cast for immobilizing a body member of a patient includes a hydrophobic sleeve having a shape configured to be applied over the body member and substantially conform to the shape of the body member, and a moldable layer configured to be positioned around said sleeve and hardened to conform to the shape of said body member adjacent said sleeve is presented. The hydrophobic sleeve includes fibers configured to wick moisture outward away from the body member, and the moldable layer includes a network of pores that extend through the moldable layer such that the pores are configured to contact the hydrophobic sleeve to promote flow of moisture from the hydrophobic sleeve outward through the moldable layer. An external removable wrap may also be detachably disposed around the moldable layer for additional support and moisture wicking.

Abstract translation: 用于固定患者的身体构件的多层铸件包括具有被配置为施加在主体构件上并基本上符合本体构件的形状的形状的疏水套管，以及构造成围绕所述套筒定位的可模制层 并且被硬化以符合邻近所述套筒的所述本体构件的形状。 疏水套管包括被配置为将湿气向外远离本体构件的纤维，并且可模塑层包括延伸穿过可模制层的孔网，使得孔构造成接触疏水套管以促进水分从疏水性 通过可成型层向外套。 外部可去除的包装也可以可拆卸地设置在可模制层周围以用于额外的支撑和湿气芯吸。

公开(公告)号：US20210238335A1

公开(公告)日：2021-08-05

申请号：US17234304

申请日：2021-04-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Benjamin M. Wu ,  Giovanny F. Acosta-Vélez

IPC: C08F283/06 ,  C09D151/08 ,  B33Y80/00

Abstract: The present invention relates in part to a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator. The invention also relates in part to a method of making the photocurable resin composition. The invention also relates in part to a method of fabricating an article comprising the steps of providing a photocurable resin composition comprising a first compound formed from the reaction of a diisocyanate and an isocyanate reactive compound comprising a double bond, a second compound comprising one or more double bonds susceptible to polymerization, and a photoinitiator; 3D printing the photocurable resin to form an article; and curing the article. The invention also relates in part to a 3D printed resin article.

公开(公告)号：US20150253320A1

公开(公告)日：2015-09-10

申请号：US14641022

申请日：2015-03-06

Applicant: The Regents of the University of California

Inventor： Daniel T. Kamei ,  Yin To Chiu ,  Benjamin M. Wu ,  Garrett L. Mosley

IPC: G01N33/543 ,  G01N33/569

CPC classification number: G01N33/558 ,  G01N33/54366 ,  G01N33/54386

Abstract: Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum. In addition, these devices and methods may be used to detect allergens in a food samples or contaminants, such as environmental toxins, in water samples. Device and kit components may be conveniently assembled in a portable container and are amenable to actuation in most settings. The devices are simple to use, requiring a non-trained operator to simply add the sample to the device. Conveniently, the time it takes to detect the target analyte is very short. Thus, the devices and methods disclosed herein provide novel and useful means for point-of-care.

Abstract translation: 本文公开了使用水相两相体系和侧流测定来检测样品中的目标分析物的装置和方法。 这些装置和方法可用于诊断生物样品如血液或血清中的疾病或病症。 此外，这些装置和方法可以用于检测水样中食物样品或污染物如环境毒素中的过敏原。 设备和套件组件可以方便地组装在便携式容器中，并且在大多数设置中可以被致动。 这些设备使用简单，需要经过培训的操作员才能将样品简单地添加到设备中。 方便地，检测目标分析物所需的时间非常短。 因此，本文公开的装置和方法提供了用于护理点的新颖和有用的手段。