公开(公告)号：US09763812B2

公开(公告)日：2017-09-19

申请号：US14622148

申请日：2015-02-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dieter Enzmann ,  Issei Kan ,  Ichiro Yuki ,  Fernando Vinuela

IPC: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2/82

CPC classification number: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2220/0008 ,  A61F2250/0023

Abstract: A coaxial stent system is described in which an inner treatment stent is configured to be coaxially positioned inside an outer anchoring stent. The outer anchoring stent is adapted for insertion into a blood vessel and anchoring to the blood vessel at a position where the outer anchoring stent spans a neck of an aneurysm. A method for endovascular treatment of aneurysms is also described.

公开(公告)号：US20150165462A1

公开(公告)日：2015-06-18

申请号：US14567152

申请日：2014-12-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ben Wu ,  Arnold Suwarnasarn ,  Fernando Vinuela ,  Ichiro Yuki

IPC: B05B12/12 ,  B05D3/02 ,  B05D3/06 ,  B05B12/02 ,  B05D1/02

CPC classification number: B05D3/0254 ,  B05D1/02 ,  B05D3/06

Abstract: Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via an atomized polymer deposition process. The resulting device is a detachable aneurysm coil system which preserves the mechanical geometry and flexibility of the coil, and delivers specific agents to promote wound healing.

Abstract translation: 用于涂覆螺旋颅内动脉瘤线圈的系统和方法，例如Guglielmi可分离线圈（GDC），使得仅沿着螺旋线圈的选定表面通过雾化聚合物沉积工艺被聚合物涂覆。 所得到的装置是可分离的动脉瘤线圈系统，其保留线圈的机械几何形状和柔性，并且递送特定的药剂以促进伤口愈合。

公开(公告)号：US09950341B2

公开(公告)日：2018-04-24

申请号：US14567152

申请日：2014-12-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ben Wu ,  Arnold Suwarnasarn ,  Fernando Vinuela ,  Ichiro Yuki

IPC: B05D3/02 ,  B05D1/02 ,  B05D3/06

CPC classification number: B05D3/0254 ,  B05D1/02 ,  B05D3/06

Abstract: Systems and methods for coating of spiral intracranial aneurysm coils, e.g., a Guglielmi Detachable Coil (GDC), such that only selected surfaces along the spiral coil are coated with a polymer via an atomized polymer deposition process. The resulting device is a detachable aneurysm coil system which preserves the mechanical geometry and flexibility of the coil, and delivers specific agents to promote wound healing.

公开(公告)号：US20170095357A1

公开(公告)日：2017-04-06

申请号：US15387422

申请日：2016-12-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Gregory P. Carman ,  Daniel S. Levi ,  Youngjae Chun ,  Fernando Vinuela

IPC: A61F2/90 ,  C23C28/00 ,  C23C14/58 ,  C23C14/18 ,  C23C16/40

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/068 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2230/0054 ,  A61L31/022 ,  A61L31/14 ,  C23C14/0005 ,  C23C14/18 ,  C23C14/185 ,  C23C14/30 ,  C23C14/34 ,  C23C14/345 ,  C23C14/5806 ,  C23C14/5873 ,  C23C16/402 ,  C23C16/513 ,  C23C28/321 ,  C23C28/345

Abstract: The various embodiments described herein include methods for fabricating thin- film flow diversion apparatuses. In one aspect, a method includes: (1) creating a plurality of trenches using photolithography and deep reactive ion etching on a substrate; (2) depositing a metal sacrificial layer on the substrate; (3) forming a Nitinol layer with a plurality of fenestrations by depositing Nitinol on the metal sacrificial layer; (4) forming a thin-film of Nitinol by removing the metal sacrificial layer; (5) crystallizing the thin-film of Nitinol; and (6) elongating the thin-film of Nitinol.

公开(公告)号：US20180369002A1

公开(公告)日：2018-12-27

申请号：US16104034

申请日：2018-08-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Greg Carman ,  Daniel S. Levi ,  Mohanchandra Kotekar Panduranga ,  Fernando Vinuela ,  Abdon E. Sepulveda

IPC: A61F2/915 ,  A61F2/90 ,  C23C14/35 ,  A61F2/07 ,  A61F2/91 ,  A61F2/82

Abstract: An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.

公开(公告)号：US20150216684A1

公开(公告)日：2015-08-06

申请号：US14622148

申请日：2015-02-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Dieter Enzmann ,  Issei Kan ,  Ichiro Yuki ,  Fernando Vinuela

IPC: A61F2/852 ,  A61F2/848

CPC classification number: A61F2/852 ,  A61F2/07 ,  A61F2/848 ,  A61F2002/823 ,  A61F2002/826 ,  A61F2220/0008 ,  A61F2250/0023

Abstract: A coaxial stent system is described in which an inner treatment stent is configured to be coaxially positioned inside an outer anchoring stent. The outer anchoring stent is adapted for insertion into a blood vessel and anchoring to the blood vessel at a position where the outer anchoring stent spans a neck of an aneurysm. A method for endovascular treatment of aneurysms is also described.

Abstract translation: 描述了一种同轴支架​​系统，其中内部治疗支架构造成同轴位于外部锚固支架内部。 外锚固支架适于插入血管并且在外锚定支架跨越动脉瘤颈部的位置处锚定到血管。 还描述了动脉瘤血管内治疗的方法。

公开(公告)号：US20140249620A1

公开(公告)日：2014-09-04

申请号：US13668241

申请日：2012-11-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Gregory P. Carman ,  Daniel S. Levi ,  Youngjae Chun ,  Fernando Vinuela

IPC: A61F2/07 ,  C23C14/58 ,  C23C14/34

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/068 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2230/0054 ,  A61L31/022 ,  A61L31/14 ,  C23C14/0005 ,  C23C14/18 ,  C23C14/185 ,  C23C14/30 ,  C23C14/34 ,  C23C14/345 ,  C23C14/5806 ,  C23C14/5873 ,  C23C16/402 ,  C23C16/513 ,  C23C28/321 ,  C23C28/345

Abstract: A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an intra-aneurismal flow velocity and vorticity. Using small size pores in a coverage area of only 10%, a 90% reduction in flow velocity into a pseudo-aneurysm can be achieved, with an almost immediate cessation of flow into an anatomical feature such as aneurysm sac in vivo. The size of the holes can be tailored to be any shape and range in size from 1-400 μm using photolithography and from 5-1000 nm using ebeam lithography.

Abstract translation: 使用超薄多孔薄膜镍钛诺描述和制造流量分流器，并且被配置为植入血管内的治疗部位以显着降低动脉内流速和涡度。 在覆盖面积仅为10％的小尺寸孔隙中，可以实现90％的流入模拟动脉瘤的流速，其中几乎立即停止流入解剖学特征如动脉瘤囊体内。 孔的尺寸可以使用光刻法定制成尺寸为1-400μm的任何形状和范围，并且使用ebeam光刻可以被定制为5-1000nm。

公开(公告)号：US10085862B2

公开(公告)日：2018-10-02

申请号：US14749930

申请日：2015-06-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Greg Carman ,  Daniel S. Levi ,  Mohanchandra Kotekar Panduranga ,  Fernando Vinuela ,  Abdon E. Sepulveda

IPC: A61F2/07 ,  A61F2/90 ,  A61F2/915 ,  C23C14/35 ,  A61F2/91 ,  A61F2/82

Abstract: An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.

公开(公告)号：US09730783B2

公开(公告)日：2017-08-15

申请号：US13668241

申请日：2012-11-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Gregory P. Carman ,  Daniel S. Levi ,  Youngjae Chun ,  Fernando Vinuela

IPC: A61F2/06 ,  A61F2/01 ,  A61F2/07 ,  A61F2/90 ,  A61L31/02 ,  A61L31/14 ,  C23C14/00 ,  C23C14/18 ,  C23C14/58 ,  C23C14/34 ,  A61F2/82

CPC classification number: A61F2/07 ,  A61F2/90 ,  A61F2002/068 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2230/0054 ,  A61L31/022 ,  A61L31/14 ,  C23C14/0005 ,  C23C14/18 ,  C23C14/185 ,  C23C14/30 ,  C23C14/34 ,  C23C14/345 ,  C23C14/5806 ,  C23C14/5873 ,  C23C16/402 ,  C23C16/513 ,  C23C28/321 ,  C23C28/345

Abstract: A flow diverter is described and fabricated using ultra-thin porous thin-film Nitinol, and is configured for implantation to a treatment site within a vessel for significant reduction in an intra-aneurismal flow velocity and vorticity. Using small size pores in a coverage area of only 10%, a 90% reduction in flow velocity into a pseudo-aneurysm can be achieved, with an almost immediate cessation of flow into an anatomical feature such as aneurysm sac in vivo. The size of the holes can be tailored to be any shape and range in size from 1-400 μm using photolithography and from 5-1000 nm using ebeam lithography.

公开(公告)号：US20150366686A1

公开(公告)日：2015-12-24

申请号：US14749930

申请日：2015-06-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Greg Carman ,  Daniel S. Levi ,  Mohanchandra Kotekar Panduranga ,  Fernando Vinuela ,  Abdon E. Sepulveda

IPC: A61F2/915 ,  A61F2/90 ,  C23C14/35 ,  A61F2/07

CPC classification number: A61F2/915 ,  A61F2/07 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/823 ,  C23C14/35

Abstract: An apparatus and method for a micro-patterned thin film Nitinol (TFN) that is used as a cover for an expandable stent structure, and has elongation/expansion properties that are configured to match the elongation/expansion properties of the expandable stent structure is presented.

Abstract translation: 用于微图案化薄膜镍钛诺（TFN）的装置和方法，其用作可扩张支架结构的盖，并且具有被配置成匹配可扩张支架结构的伸长/膨胀性能的伸长/膨胀性质 。