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公开(公告)号：US20240226272A9
公开(公告)日：2024-07-11
申请号：US18257808
申请日：2021-12-17
IPC分类号： A61K39/215 , A61K39/00 , C07K14/005 , C12N7/00 , C12N9/88
CPC分类号： A61K39/215 , C07K14/005 , C12N7/00 , C12N9/88 , A61K2039/53 , C12N2740/16034 , C12N2760/20034 , C12N2770/20034 , C12Y402/0101
摘要： Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.
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公开(公告)号：US20240131148A1
公开(公告)日：2024-04-25
申请号：US18257808
申请日：2021-12-17
IPC分类号： A61K39/215 , A61K39/00 , C07K14/005 , C12N7/00 , C12N9/88
CPC分类号： A61K39/215 , C07K14/005 , C12N7/00 , C12N9/88 , A61K2039/53 , C12N2740/16034 , C12N2760/20034 , C12N2770/20034 , C12Y402/0101
摘要： Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.
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公开(公告)号：US20210363195A1
公开(公告)日：2021-11-25
申请号：US17335244
申请日：2021-06-01
发明人： Jon M. STEICHEN , William R. SCHIEF
摘要： The present disclosure relates to recombinant HIV Env polypeptides and their use in the treatment and prevention of HIV/AIDS.
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