公开(公告)号：US20240226272A9

公开(公告)日：2024-07-11

申请号：US18257808

申请日：2021-12-17

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： William R. SCHIEF ,  Torben SCHIFFNER ,  Jon M. STEICHEN ,  Xiaozhen HU

IPC分类号： A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88

CPC分类号： A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88 ,  A61K2039/53 ,  C12N2740/16034 ,  C12N2760/20034 ,  C12N2770/20034 ,  C12Y402/0101

摘要： Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.

公开(公告)号：US20240131148A1

公开(公告)日：2024-04-25

申请号：US18257808

申请日：2021-12-17

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： William R. SCHIEF ,  Torben SCHIFFNER ,  Jon M. STEICHEN ,  Xiaozhen HU

IPC分类号： A61K39/215 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88

CPC分类号： A61K39/215 ,  C07K14/005 ,  C12N7/00 ,  C12N9/88 ,  A61K2039/53 ,  C12N2740/16034 ,  C12N2760/20034 ,  C12N2770/20034 ,  C12Y402/0101

摘要： Provided herein are glycan engineered SARS-CoV-2 RBD polypeptides, fusion polypeptides comprising thereof, and immunogenic compositions comprising thereof. Also provided are methods of administering the RBD polypeptide, fusion polypeptide or immunogenic composition to a subject to elicit an immune response. Also provided are polynucleotides encoding the fusion polypeptide, and methods of administering a composition comprising the polynucleotide to a subject to elicit an immune response. In some embodiments, the polynucleotide is an RNA comprising modified ribonucleotides.

公开(公告)号：US20230190914A1

公开(公告)日：2023-06-22

申请号：US18048960

申请日：2022-10-24

申请人： INTERNATIONAL AIDS VACCINE INITIATIVE, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

发明人： William SCHIEF ,  Manyuan MA ,  Jon STEICHEN ,  Xiaozhen HU ,  Sebastian RAEMISCH ,  Alessia LIGUORI ,  Torben SCHIFFNER ,  Jordan WILLIS ,  Christopher COTTRELL

IPC分类号： A61K39/21 ,  C07K14/005 ,  A61P31/18

CPC分类号： A61K39/21 ,  A61P31/18 ,  C07K14/005 ,  A61K2039/575 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16071

摘要： The invention relates to germline-targeting designs, stabilization designs, and/or combinations thereof, of proteins designed with modified surfaces helpful for immunization regimens, other protein modifications and/or development of nanoparticles, methods of making and using the same, and to (a) germline-targeting priming or boosting/shepherding immunogens to initiate or guide maturation of VRC01-class responses (b) PCT64/PG9-germline-targeting designs (c) BG18-germline-targeting designs or boosting/shepherding immunogens to initiate or guide maturation of BG18-like responses, and/or (d) trimer stabilization and presentation in a membrane-bound format.

公开(公告)号：US20240247033A1

公开(公告)日：2024-07-25

申请号：US18002611

申请日：2021-06-22

申请人： The Scripps Research Institute

发明人： William SCHIEF ,  Jon STEICHEN ,  Torben SCHIFFNER ,  Xiaozhen HU ,  Christoper COTTRELL

IPC分类号： C07K14/005 ,  A61K39/215 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K39/215 ,  G01N33/56983 ,  C07K2319/03 ,  C07K2319/91 ,  C12N2740/16022 ,  C12N2770/20022 ,  C12N2770/20034 ,  G01N2333/165 ,  G01N2469/20

摘要： The present invention relates to glycan-masked and membrane-tethered SARS-CoV-2 RBD vaccine constructs and methods for making and administering the same. The present invention also encompasses a general vaccine platform for coronaviruses.