公开(公告)号：US20160263402A1

公开(公告)日：2016-09-15

申请号：US15160576

申请日：2016-05-20

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Rongxiao Zhang ,  Brian William Pogue ,  Adam K. Glaser ,  David J. Gladstone ,  Lesley A. Jarvis ,  Jacqueline M. Andreozzi ,  Shudong Jiang ,  Scott Christian Davis ,  Johan Jakob Axelsson

IPC: A61N5/10

CPC classification number: A61N5/1071 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1077 ,  A61N2005/1054 ,  A61N2005/1059

Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.

Abstract translation: 使用穿过治疗区域的辐射束进行脉冲高能量放射治疗的监测仪，0.2MEV或更大的辐射; 有一个摄像头，用于对来自治疗区的切伦科夫灯进行成像; 用于防止室内照明干扰的装置，照相机与辐射束的脉冲同步; 以及图像处理器，适于从图像确定患者皮肤上的束区域的范围。 此外，图像处理器从图像确定处理区域中的累积皮肤剂量。 在实施例中，处理器使用对象的三维模型来确定切伦科夫光图像中的图像强度与皮肤中的辐射强度的映射，将切布伦科夫光图像应用于图像以验证皮肤剂量递送，并且通过 总结皮肤剂量图。

公开(公告)号：US12036421B2

公开(公告)日：2024-07-16

申请号：US18563813

申请日：2022-05-25

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Petr Bruza ,  Brian Pogue ,  Ramish Ashraf ,  Rongxiao Zhang ,  David Gladstone ,  Megan Clark ,  Roman Vasyltsiv

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1071 ,  A61N2005/1059

Abstract: A system for delivering ultra-high dose rate irradiation to a target area of a patient, includes a pulsed charged-particle source along a beam axis; a collimator for shaping the beam of radiation; one or more cameras for imaging the target area of the patient; and a dosimetry controller for providing control signals to the charged-particle source one or more dosimeters positioned between an output of the charged-particle source and the collimator in beam fringes for measuring a radiation dosage provided by each pulse; and a beam scanning coil positioned between the collimator and the patient for directing the shaped beam. The dosimetry controller receives feedback from the one or more dosimeters and provides control signals to the particle source and the beam scanning coil that modulate final pulses in the series of pulses in real-time.

公开(公告)号：US10940332B2

公开(公告)日：2021-03-09

申请号：US15160576

申请日：2016-05-20

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Rongxiao Zhang ,  Brian William Pogue ,  Adam K. Glaser ,  David J. Gladstone ,  Lesley A. Jarvis ,  Jacqueline M. Andreozzi ,  Shudong Jiang ,  Scott Christian Davis ,  Johan Jakob Axelsson

IPC: A61B5/05 ,  A61B5/00 ,  A61N5/10

Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.