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公开(公告)号：US12102734B2
公开(公告)日：2024-10-01
申请号：US17239322
申请日：2021-04-23
CPC分类号： A61L27/3839 , A61L27/04 , A61L27/3633 , A61L27/50 , B33Y80/00 , A61L27/14 , A61L2300/414 , A61L2420/04 , A61L2420/08
摘要： A method of producing bioengineered tissue includes coating a microstructured fiber with a bioink containing a plurality of living cells. The microstructured fiber is embedded with microfluidic channels defining periodic outlet apertures, a plurality of ultrasonic transducers, at least one chemical sensor, and at least one temperature sensor. The method further includes applying the coated fiber to an anatomic model of an organ. The microfluidic channels and outlet apertures of the fiber are configured to function as an artificial blood-vessel system to the bioengineered tissue, thereby supplying building material for the proliferation of the plurality of living cells, and allowing the bioengineered tissue to mature into functional tissue.
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公开(公告)号：US20210330864A1
公开(公告)日：2021-10-28
申请号：US17239322
申请日：2021-04-23
IPC分类号： A61L27/38
摘要： A method of producing bioengineered tissue includes coating a microstructured fiber with a bioink containing a plurality of living cells. The microstructured fiber is embedded with microfluidic channels defining periodic outlet apertures, a plurality of ultrasonic transducers, at least one chemical sensor, and at least one temperature sensor. The method further includes applying the coated fiber to an anatomic model of an organ. The microfluidic channels and outlet apertures of the fiber are configured to function as an artificial blood-vessel system to the bioengineered tissue, thereby supplying building material for the proliferation of the plurality of living cells, and allowing the bioengineered tissue to mature into functional tissue.
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公开(公告)号：US11629325B2
公开(公告)日：2023-04-18
申请号：US16834572
申请日：2020-03-30
摘要： A platform for testing cell response to biochemical agents. The TrophoWell™ includes a well which contains a gel, and a plurality of capillaries that open into it. Cells and various biochemical agents such as drugs and growth factors are flown through those capillaries. The platform allows for the evaluation of cell response by imaging. The platform is a cost effective testing platform and can be used in the fields for drug discovery and personalized medicine.
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公开(公告)号：US20210301244A1
公开(公告)日：2021-09-30
申请号：US16834572
申请日：2020-03-30
摘要： A platform for testing cell response to biochemical agents. The TrophoWell™ includes a well which contains a gel, and a plurality of capillaries that open into it. Cells and various biochemical agents such as drugs and growth factors are flown through those capillaries. The platform allows for the evaluation of cell response by imaging. The platform is a cost effective testing platform and can be used in the fields for drug discovery and personalized medicine.
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