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公开(公告)号：US20190126043A1
公开(公告)日：2019-05-02
申请号：US16093036
申请日：2017-04-14
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , H. Isaac Chen , Douglas H. Smith , Mijail Serruya
IPC分类号： A61N1/36 , A61N1/05 , A61N5/06 , A61B5/0478
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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公开(公告)号：US09895399B2
公开(公告)日：2018-02-20
申请号：US14764450
申请日：2014-01-31
发明人： Douglas H. Smith , Kacy D. Cullen , John A. Wolf
IPC分类号： A61K35/30
CPC分类号： A61K35/30
摘要： The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
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公开(公告)号：US20240359010A1
公开(公告)日：2024-10-31
申请号：US18763996
申请日：2024-07-03
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , Han-Chiao Isaac Chen , Douglas H. Smith , Mijail Serruya
CPC分类号： A61N1/36067 , A61B5/293 , A61B5/6868 , A61N1/05 , A61N1/0536 , A61N1/36182 , A61N5/0601 , A61N5/0622 , A61B5/0059 , A61B5/01 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61N1/0531
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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公开(公告)号：US20150352153A1
公开(公告)日：2015-12-10
申请号：US14764450
申请日：2014-01-31
发明人： Douglas H. Smith , Kacy D. Cullen , John A. Wolf
IPC分类号： A61K35/30
CPC分类号： A61K35/30
摘要： The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
摘要翻译： 本发明涉及用于维持神经损伤后远端神经节段的再生能力的方法和组合物。
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公开(公告)号：US12090323B2
公开(公告)日：2024-09-17
申请号：US17358851
申请日：2021-06-25
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , Han-Chiao Isaac Chen , Douglas H. Smith , Mijail Serruya
CPC分类号： A61N1/36067 , A61B5/24 , A61B5/291 , A61B5/6868 , A61N1/05 , A61N1/0536 , A61N1/36182 , A61N5/0601 , A61N5/0622 , A61B5/0059 , A61B5/01 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61N1/0531
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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公开(公告)号：US20210393960A1
公开(公告)日：2021-12-23
申请号：US17358851
申请日：2021-06-25
发明人： Daniel Kacy Cullen , James P. Harris , John A. Wolf , Han-Chiao Isaac Chen , Douglas H. Smith , Mijail Serruya
摘要： In one aspect, the invention comprises an implantable living electrode comprising a substantially cylindrical extracellular matrix core; one or more neurons implanted along or within the substantially cylindrical extracellular matrix core, the one or more neurons including one or more optogenetic or magnetogenetic neurons proximal to a first end of the implantable living electrode.
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公开(公告)号：US10525085B2
公开(公告)日：2020-01-07
申请号：US15863278
申请日：2018-01-05
IPC分类号： A61K35/30
摘要： The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
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8.发明申请Device and Method Using Integrated Neuronal Cells and an Electronic Device 审中-公开使用集成神经元细胞和电子装置的装置和方法公开(公告)号：US20130238041A1
公开(公告)日：2013-09-12
申请号：US13776807
申请日：2013-02-26
发明人： Douglas H. Smith , Bryan Pfister , David F. Meaney
IPC分类号： A61N1/04
CPC分类号： A61N1/04 , A61N1/05 , A61N1/326 , A61N1/36103
摘要： The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.
摘要翻译： 本发明提供了与电子设备接口的集成神经细胞的装置及其制造方法。
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