公开(公告)号：US11963697B2

公开(公告)日：2024-04-23

申请号：US18138978

申请日：2023-04-25

Applicant: The Regents of the University of California

Inventor： Timothy L. Hanson ,  Michel M. Maharbiz ,  Philip N. Sabes

IPC: A61B17/34 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/293 ,  A61B17/00 ,  A61N1/05 ,  A61N5/06 ,  A61N5/067

CPC classification number: A61B17/3468 ,  A61B5/0084 ,  A61B5/1473 ,  A61B5/293 ,  A61B5/688 ,  A61B5/6882 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N5/0601 ,  A61N5/0622 ,  A61B2017/00526 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N5/067

Abstract: Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.

公开(公告)号：US11938313B2

公开(公告)日：2024-03-26

申请号：US17452416

申请日：2021-10-27

Applicant: Cadwell Laboratories, Inc.

Inventor： John A. Cadwell

IPC: A61N1/05 ,  A61B5/06 ,  A61B5/279 ,  A61B5/293 ,  A61N1/372 ,  A61B1/313 ,  A61N1/36

CPC classification number: A61N1/0539 ,  A61B5/063 ,  A61B5/279 ,  A61B5/293 ,  A61N1/0531 ,  A61N1/37205 ,  A61B1/313 ,  A61B2562/046 ,  A61N1/36064

Abstract: A system for deploying an electrode array at a target location through a hole formed in the patient's cranium. The system includes an array of electrodes attached to a substrate and an inserter attached to the substrate and/or the array of electrodes. The inserter, substrate and array of electrodes are configured into a first compressed state and are positioned within the lumen of a cannula. Using the cannula, the system is inserted through the hole, the cannula is then removed, and the inserter is used to transition the substrate and electrode array from the first compressed state to a second uncompressed state, thereby deploying the array of electrodes at the target location.

公开(公告)号：US20240257992A1

公开(公告)日：2024-08-01

申请号：US18578660

申请日：2022-07-14

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Andrew B. Schwartz ,  May Yoon PWINT

IPC: H01B7/00 ,  A61B5/293 ,  C23C14/04 ,  C23C14/08 ,  C23C14/14 ,  C23C16/04 ,  C23C16/56 ,  G06F3/01 ,  H01B13/00

CPC classification number: H01B7/0009 ,  A61B5/293 ,  C23C14/042 ,  C23C14/081 ,  C23C14/14 ,  C23C16/04 ,  C23C16/56 ,  G06F3/015 ,  H01B13/0036 ,  A61B2562/222

Abstract: Disclosed herein is a method for forming a cable configured to convey neuron signals. The method can include forming two longitudinal halves of the cable and bonding the two longitudinal halves together. Each of the two longitudinal halves can be formed on a respective substrate and includes a plurality of groups of conductive traces each in a respective layer of the respective longitudinal half. Each respective group of the plurality of groups of conductive traces can formed by depositing a respective insulating layer, patterning the respective insulating layer, depositing a respective conductive layer over at least a portion of the patterned insulating layer, patterning the respective conductive layer into the respective group of conductive traces. Each respective layer of the respective longitudinal half can have a width smaller than a layer formed prior to the respective layer, and can have a thickness that is within a range of 2 microns and 10 microns.

公开(公告)号：US11986304B2

公开(公告)日：2024-05-21

申请号：US16986322

申请日：2020-08-06

Applicant: Albert-Ludwigs-Universität Freiburg

Inventor： Yiannos Manoli ,  Daniel De Dorigo ,  Christian Moranz ,  Hagen Graf

IPC: A61B5/293 ,  A61B5/00 ,  A61B5/24

CPC classification number: A61B5/24 ,  A61B5/293 ,  A61B5/6848 ,  A61B2562/043

Abstract: A sensor array includes a base for providing a probe signal and a plurality of modular recording sites. Each modular recording site of the plurality of modular recording sites is configured for receiving a signal, for converting the signal into a digital sensor signal and to provide the digital sensor signal to the base. The base is configured for receiving a plurality of digital sensor signals from the plurality of modular recording sites and to process the plurality of digital sensor signals so as to provide the probe signal.

公开(公告)号：US20240134453A1

公开(公告)日：2024-04-25

申请号：US18493323

申请日：2023-10-23

Applicant: PRECISION NEUROSCIENCE CORPORATION

Inventor： Benjamin I. RAPOPORT ,  Craig H. MERMEL ,  Daniel TRIETSCH ,  Elton HO ,  Kazutaka TAKAHASHI

IPC: G06F3/01 ,  A61B5/293 ,  G06N20/00

CPC classification number: G06F3/015 ,  A61B5/293 ,  G06N20/00 ,  A61B2560/0223 ,  A61B2562/046

Abstract: A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

公开(公告)号：US20230248471A1

公开(公告)日：2023-08-10

申请号：US18008596

申请日：2021-04-30

Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： Ludovic Serex ,  Nicolas Vachicouras ,  Benoit Huguet ,  Florian Fallegger

IPC: A61B90/92

CPC classification number: A61B90/92 ,  A61B5/293

Abstract: A method for labelling a portion of a device includes the steps of providing a first substrate layer of a transparent or translucent material, depositing a first coloured material onto the first substrate layer in a labelling portion of the layer, thereby obtaining a labelling item, and coupling the labelling item to the device. The method is particularly suitable for producing labelled stretchable devices such as soft body-implantable devices for sensing a physiological signal and/or stimulating an electrical and/or pharmacological activity of a body tissue or organ in a subject.

公开(公告)号：US20230200898A1

公开(公告)日：2023-06-29

申请号：US18114906

申请日：2023-02-27

Applicant: JUAD, INC.

Inventor： JOSE MIGUEL MORALES

IPC: A61B18/14 ,  A61B90/00 ,  A61B5/293 ,  A61B5/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B18/1492 ,  A61B5/293 ,  A61B5/6853 ,  A61B5/6859 ,  A61B5/6868 ,  A61B90/37 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61B2018/0016 ,  A61B2090/064 ,  A61B2090/363 ,  A61B2090/378 ,  A61B2090/3784

Abstract: The present disclosure discusses a devices, systems and methods for transvascular, transvenous and/or transdural access, to the brain parenchyma, subarachnoid or subdural spaces. In some embodiments, the disclosed systems and methods may be used for local drug delivery, tissue biopsy, nanofluidic or microelectronic device/component delivery/insertion/implantation, in situ imaging, ablation of abnormal brain tissue and the like. Embodiments of the present disclosure include an access catheter system for extravascular procedures in the brain having an elongate, flexible tubular body, with at least one lumen extending axially there through between a proximal end, and a distal end. The access catheter system may include a side exit port and a distal end port. Further, the access catheter system may include a selective deflector positioned within the lumen configured to deflect a procedure catheter and permit a guide catheter.

公开(公告)号：US20230148968A1

公开(公告)日：2023-05-18

申请号：US17529224

申请日：2021-11-17

Applicant: Neuralink Corp.

Inventor： Ik Soo Kwon ,  Dongjin Seo ,  John W.F. To

IPC: A61B5/00 ,  H01B3/30 ,  H01B7/04 ,  A61B5/293

CPC classification number: A61B5/6868 ,  A61B5/293 ,  H01B3/306 ,  H01B7/048 ,  A61B2562/125 ,  A61B2562/0209 ,  G06F3/015

Abstract: An implantable device and method of manufacture include a substantially hermetic polychlorotrifluoroethylene (PCTFE) enclosure with closely-spaced wires extending through a slit in the enclosure. A method for manufacturing the implantable device includes cutting a slit in a piece of polymer and extending a plurality of insulated wires through the slit. Each of the insulated wires are parallel to a neighboring wire of the insulated wires. The piece of polymer is thermally bonded around each wire of the plurality of insulated wires such that the piece of polymer is sealed around insulation of each wire with a portion of each wire extending through the piece of polymer.

公开(公告)号：US20240324932A1

公开(公告)日：2024-10-03

申请号：US18037117

申请日：2021-11-24

Applicant: Precisis GmbH

Inventor： Lasse JAGSCHIES

IPC: A61B5/293 ,  A61B5/372 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61B5/293 ,  A61B5/372 ,  A61N1/0529 ,  A61N1/36135

Abstract: The invention relates to a system for sensing EEG signals on a living being, wherein the system includes multiple EEG electrodes for picking up electrical signals on the living being and at least one evaluation device connected to the EEG electrodes, wherein the evaluation device is configured to carry out at least the following steps:



a) picking up EEG signals from the EEG electrodes,
b) calculating at least bipolar and quadrupolar field components of the electrical field in the living being, which is the cause of the EEG signals, from the EEG signals,
c) determining at least one physiological key value of the living being from the calculated at least bipolar and quadrupolar field components.

公开(公告)号：US20240285213A1

公开(公告)日：2024-08-29

申请号：US18594052

申请日：2024-03-04

Applicant: Neural Dynamics Technologies Inc.

Inventor： Ingrid VAN WELIE ,  Girish RUGHOOBUR

IPC: A61B5/293 ,  A61B5/00 ,  A61B5/304 ,  A61B5/31 ,  A61N1/05

CPC classification number: A61B5/293 ,  A61B5/0031 ,  A61B5/304 ,  A61B5/31 ,  A61B5/7225 ,  A61N1/0534 ,  A61B2560/0219 ,  A61B2562/125

Abstract: Systems and methods are disclosed for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions. In one implementation, a system for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions comprises a neural probe configured for placement within a brain; at least one signal lead extending from the neural probe; a sensing assembly included on the neural probe including a plurality of electrodes, at least one amplifier configured to generate at least one amplification signal based on the sensed electrical signals generated by the neurons, and at least one multiplexer configured to multiplex at least two amplified signals based on the sensed electrical signals generated by neurons; and an externally located processing assembly with electrical components for analogue to digital conversion of signals, a signal generator, a power source, and electronic circuitry enabling wireless transfer of data and wireless charging of power.