公开(公告)号：US20230227512A1

公开(公告)日：2023-07-20

申请号：US17937719

申请日：2022-10-03

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  John Mascola ,  Baoshan Zhang ,  Cheng Cheng ,  Mallika Sastry ,  Aliaksandr Druz

IPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/10 ,  G01N33/569

CPC分类号： C07K14/435 ,  A61K39/12 ,  C07K14/005 ,  A61K39/21 ,  C07K16/1063 ,  G01N33/56988 ,  C12N2740/16122 ,  C12N2740/16134 ,  A61K2039/55555

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

公开(公告)号：US20220152194A1

公开(公告)日：2022-05-19

申请号：US17587817

申请日：2022-01-28

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Xuejun Chen ,  Jeffrey Boyington ,  Hongying Duan Holdsworth ,  Cheng Cheng ,  John R. Mascola

IPC分类号： A61K39/21 ,  C07K14/005 ,  C12N7/00 ,  C07K14/16

摘要： Embodiments of immunogens based on the outer domain of HIV-1 gp120 and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to prime an immune response to gp120 in a subject, for example, to treat or prevent an HIV-1 infection in the subject.

公开(公告)号：US20210198324A1

公开(公告)日：2021-07-01

申请号：US17202231

申请日：2021-03-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  C12N7/00

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

公开(公告)号：US20200230229A1

公开(公告)日：2020-07-23

申请号：US16338964

申请日：2017-10-03

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC

发明人： Peter Kwong ,  Rui Kong ,  Tongqing Zhou ,  John Mascola ,  Kai Xu ,  Michael Gordon Joyce ,  Cheng Cheng ,  Gwo-Yu Chuang ,  Kevin Liu ,  Baoshan Zhang ,  Li Ou ,  Wing-Pui Kong ,  Yongping Yang

IPC分类号： A61K39/21 ,  C12N7/00 ,  A61K47/64 ,  A61P31/18 ,  C07K14/005

摘要： Embodiments of immunogens based on the HIV-1 Env fusion peptide and methods of their use and production are disclosed. Nucleic acid molecules encoding the immunogens are also provided. In several embodiments, the immunogens can be used to generate an immune response to HIV-1 Env in a subject, for example, to treat or prevent an HIV-1 infection in the subject.