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公开(公告)号：US20230301788A1
公开(公告)日：2023-09-28
申请号：US18326753
申请日：2023-05-31
申请人： Titan Spine, Inc.
CPC分类号： A61F2/30767 , A61L27/06 , A61L27/50 , A61B17/58 , A61F2/2846 , A61F2002/30838 , A61F2002/3084 , A61F2002/3093 , A61F2002/30968 , A61F2002/3097 , A61F2002/30985 , A61L2400/18 , A61F2/3094
摘要： An orthopedic implant having a titanium or titanium alloy body with a plurality of surfaces. The orthopedic implant is produced according to a process comprising the steps of: (a) additively building the orthopedic implant; and then (b) mechanically, chemically, or mechanically and chemically eroding one or more surfaces of the orthopedic implant to (i) remove alpha case from, and (ii) impart an osteoinducting roughness including micro-scale structures and nano-scale structures into, the one or more surfaces.
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公开(公告)号：US20190231535A1
公开(公告)日：2019-08-01
申请号：US16318961
申请日：2017-06-29
申请人： Titan Spine, Inc.
摘要： An orthopedic implant having a titanium or titanium alloy body with a plurality of surfaces. The orthopedic implant is produced according to a process comprising the steps of: (a) additively building the orthopedic implant; and then (b) mechanically, chemically, or mechanically and chemically eroding one or more surfaces of the orthopedic implant to (i) remove alpha case from, and (ii) impart an osteoinducting roughness including micro-scale structures and nano-scale structures into, the one or more surfaces.
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公开(公告)号：US20190192303A1
公开(公告)日：2019-06-27
申请号：US16322373
申请日：2017-06-29
申请人： Titan Spine, Inc.
CPC分类号： A61F2/30767 , A61B17/58 , A61F2002/30838 , A61F2002/3084 , A61F2002/3093 , A61F2002/30968 , A61F2002/3097 , A61F2002/30985 , A61F2002/30986 , A61L27/06 , A61L27/50 , A61L2400/18
摘要： Bone-contacting surfaces and free surfaces of orthopedic implants. The implants are additively manufactured, followed by mechanical, chemical, or mechanical and chemical erosion. At least some of the surfaces of the implants include an osteoinducting roughness that has micro-scale structures and nano-scale structures that facilitate and enhance osteoinduction and osteogenesis, as well as enhanced alkaline phosphatase, osterix, and osteocalcin expression levels along the pathway of mesenchymal stem cell differentiation to osteoblasts.
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公开(公告)号：US20180333782A1
公开(公告)日：2018-11-22
申请号：US15777345
申请日：2016-11-21
申请人： TITAN SPINE, INC.
IPC分类号： B22F3/24 , A61L27/06 , B24C3/32 , B24C11/00 , B22F3/105 , B22F5/10 , B33Y10/00 , B33Y40/00 , C22C1/04
CPC分类号： B22F3/24 , A61L27/04 , A61L27/06 , A61L2400/12 , A61L2430/02 , B22F3/1055 , B22F5/10 , B22F2003/241 , B22F2003/244 , B22F2003/247 , B22F2301/205 , B22F2998/10 , B24C1/00 , B24C3/32 , B24C3/325 , B24C11/00 , B33Y10/00 , B33Y40/00 , C22C1/0458 , B22F3/15 , B23H3/00
摘要： Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.
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公开(公告)号：US11712339B2
公开(公告)日：2023-08-01
申请号：US17009610
申请日：2020-09-01
申请人： Titan Spine, Inc.
CPC分类号： A61F2/30767 , A61B17/58 , A61F2/2846 , A61L27/06 , A61L27/50 , A61F2/3094 , A61F2002/3084 , A61F2002/3093 , A61F2002/3097 , A61F2002/30838 , A61F2002/30968 , A61F2002/30985 , A61L2400/18
摘要： An orthopedic implant having a titanium or titanium alloy body with a plurality of surfaces. The orthopedic implant is produced according to a process comprising the steps of: (a) additively building the orthopedic implant; and then (b) mechanically, chemically, or mechanically and chemically eroding one or more surfaces of the orthopedic implant to (i) remove alpha case from, and (ii) impart an osteoinducting roughness including micro-scale structures and nano-scale structures into, the one or more surfaces.
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公开(公告)号：US11690723B2
公开(公告)日：2023-07-04
申请号：US16322373
申请日：2017-06-29
申请人： Titan Spine, Inc.
CPC分类号： A61F2/30767 , A61B17/58 , A61F2/2846 , A61L27/06 , A61L27/50 , A61F2/3094 , A61F2002/3084 , A61F2002/3093 , A61F2002/3097 , A61F2002/30838 , A61F2002/30968 , A61F2002/30985 , A61L2400/18
摘要： Bone-contacting surfaces and free surfaces of orthopedic implants. The implants are additively manufactured, followed by mechanical, chemical, or mechanical and chemical erosion. At least some of the surfaces of the implants include an osteoinducting roughness that has micro-scale structures and nano-scale structures that facilitate and enhance osteoinduction and osteogenesis, as well as enhanced alkaline phosphatase, osterix, and osteocalcin expression levels along the pathway of mesenchymal stem cell differentiation to osteoblasts.
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公开(公告)号：US20220355375A1
公开(公告)日：2022-11-10
申请号：US17853643
申请日：2022-06-29
申请人： Titan Spine, Inc.
摘要： Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.
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公开(公告)号：US11376660B2
公开(公告)日：2022-07-05
申请号：US15777435
申请日：2016-11-21
申请人： Titan Spine, Inc.
IPC分类号： B22F3/24 , B22F3/105 , B33Y10/00 , C22C1/04 , B22F3/15 , A61L27/06 , A61F2/44 , B33Y80/00 , A61F2/30 , B22F10/20
摘要： Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.
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公开(公告)号：US11370025B2
公开(公告)日：2022-06-28
申请号：US15777345
申请日：2016-11-21
申请人： Titan Spine, Inc.
IPC分类号： B22F3/24 , C22C1/04 , B33Y10/00 , B33Y40/00 , A61L27/04 , B24C3/32 , B22F10/00 , B24C11/00 , B24C1/00 , A61L27/06 , B22F5/10 , B22F10/20
摘要： Orthopedic implants produced by additive manufacture, followed by refinement of exterior and interior surfaces trough mechanical erosion, chemical erosion, or a combination of mechanical and chemical erosion. Surface refinement removes debris, and also produces bone-growth enhancing micro-scale and nano-scale structures.
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10.发明授权公开(公告)号：US11096796B2
公开(公告)日：2021-08-24
申请号：US13784144
申请日：2013-03-04
申请人： Titan Spine, Inc.
摘要： Interbody spinal implants comprise internal sidewalls having a roughened surface topography. The internal sidewalls may be those that surround a substantially hollow implant center, including the sidewalls of a vertical aperture and sidewalls of a transverse aperture. The roughened surface topography comprises macro, micro, and nano features that comprise an amplitude, a peak to valley height, and spacing.
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