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    Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients
    1.
    发明授权
    Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients 失效
    硫酸化生育酚低聚糖和包括与活性成分相同的抗病毒剂

    公开(公告)号：US5280111A

    公开(公告)日：1994-01-18

    申请号：US856710

    申请日：1992-03-24

    申请人： Tadao Shoji ,  Naoya Ikushima ,  Kaname Katsuraya ,  Nahoko Takahashi ,  Fusayo Kobayashi ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima

    发明人： Tadao Shoji ,  Naoya Ikushima ,  Kaname Katsuraya ,  Nahoko Takahashi ,  Fusayo Kobayashi ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima

    IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/12 ,  A61P31/18 ,  C07H17/065 ,  C07H15/20 ,  A61K31/72 ,  C07H11/00 ,  C07H13/02 ,  C07H17/04

    CPC分类号： C07H17/065 ,  A61K31/70

    摘要： The present invention relates to novel tocopheryl oligosaccharides, acylated tocopheryl oligosaccharides, sulfated tocopheryl oligosaccharides, and antiviral agents including the sulfated tocopheryl oligosaccharides as active ingredients. In the tocopheryl oligosaccharide, the hydrogen atom of the hydroxy group at the 1-position in the terminal sugar moiety of an oligosaccharide which consists of 3.about.20 of identical or different repeating monosaccharide units selected from the group consisting of glucose, galactose, mannose, talose, idose, altrose, allose, glucose, xylose, arabinose, rhamnose, fucose, and fructose, which are glycoside-linked, is substituted by a tocopherol group. In the acylated tocopheryl oligosaccharides, each of any hydroxy group of the sugar moiety, other than the hydroxy group at the 1-position in the terminal sugar moiety of the oligosaccharide described above, is protected by an acyl group. The antiviral agents including the sulfated tocopheryl oligosaccharides or the biologically acceptable salt of the same as active ingredients have low toxicities and exhibit improved antiviral action, especially against the Human Immunodeficiency Virus.

    摘要翻译： 本发明涉及新的生育酚低聚糖，酰化生育酚低聚糖，硫酸生育酚寡糖，以及包含硫酸生育酚寡糖作为活性成分的抗病毒剂。 在生育酚低聚糖中，低聚糖的末端糖部分的1位的羟基的氢原子由3〜20个相同或不同的重复单糖单元组成，所述重复单糖单元选自葡萄糖，半乳糖，甘露糖， 与糖生成酚基取代的与糖苷连接的谷氨酸，阿糖，阿卓糖，阿洛糖，葡萄糖，木糖，阿拉伯糖，鼠李糖，岩藻糖和果糖。 在酰化的生育酚低聚糖中，除了上述寡糖的末端糖部分的1位以外的除了羟基以外的糖部分的任何羟基都被酰基保护。 包括硫酸生育酚寡糖或与生物活性成分相同的生物学上可接受的盐的抗病毒剂具有低毒性，并且表现出改善的抗病毒作用，特别是针对人类免疫缺陷病毒。

    Oligosaccharide aromatic glycoside and sulfate thereof
    2.
    发明授权
    Oligosaccharide aromatic glycoside and sulfate thereof 失效
    寡糖芳香糖苷及其硫酸盐

    公开(公告)号：US5498602A

    公开(公告)日：1996-03-12

    申请号：US944077

    申请日：1992-09-11

    申请人： Tadao Shoji ,  Nahoko Takahashi ,  Naoya Ikushima ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima ,  Kaname Katsuraya ,  Koichiro Adachi ,  Fusayo Kataoka

    发明人： Tadao Shoji ,  Nahoko Takahashi ,  Naoya Ikushima ,  Toshiyuki Uryu ,  Takashi Yoshida ,  Naoki Yamamoto ,  Hideki Nakashima ,  Kaname Katsuraya ,  Koichiro Adachi ,  Fusayo Kataoka

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61P31/12 ,  A61P31/18 ,  C07H15/203 ,  C08B37/00 ,  C07G3/00 ,  C07H11/00

    CPC分类号： C07H15/203 ,  C08B37/006

    摘要： Oligosaccharide aromatic glycoside sulfates and physiologically acceptable salts thereof, are disclosed. Further, antiviral agents having these sulfate compounds as the active components, and particularly an antiviral agent, wherein the virus is one which causes AIDS (Acquired Immune Deficiency Syndrome), are disclosed. The active components or the glycoside sulfates, and the salts thereof, are characterized by an oligosaccharide aromatic glycoside sulfate in which the hydrogen of the position-1 hydroxyl group of the terminal sugar of an oligosaccharide is substituted with a specified formula having an alkyl group consisting of 1 to 18 carbons, an oxygen or no oxygen, and an allylene group. The number of constituent monosaccharides in the oligosaccharide portion is preferably within a range of 2 to 20. Further, 10% or more of the remaining hydroxyl groups of the sugar subunits are subjected to sulfated esterification. In addition the antiviral agent exhibits low toxicity and is useful in the treatment of AIDS. Furthermore, an oligosaccharide is also disclosed as described above with the exception that it is the hydrogen atom of the position 1 hydrogen group at the terminal sugar residue which is substituted with the specified formula, also described above. However, in addition the remaining hydroxyl groups of the sugar portion of this oligosaccharide are protected by acyl groups or are present in an unprotected form. Also disclosed is a method for the production of an oligosaccharide aromatic glycoside sulfate synthesized by sulfation using a sulfating agent.

    摘要翻译： 公开了寡糖芳香糖苷硫酸盐及其生理上可接受的盐。 此外，公开了具有这些硫酸盐化合物作为活性成分的抗病毒剂，特别是其中病毒是引起AIDS（获得性免疫缺陷综合征）的抗病毒剂。 活性成分或糖苷硫酸盐及其盐的特征在于寡糖芳香糖苷硫酸盐，其中寡糖末端糖的位置1羟基的氢被具有烷基的特定式所取代， 1至18个碳，氧或无氧，以及烯丙基。 寡糖部分中的构成单糖的数量优选在2〜20的范围内。此外，将糖亚基的剩余羟基的10％以上进行硫酸化酯化。 此外，抗病毒剂的毒性低，可用于治疗艾滋病。 此外，还公开了如上所述的寡糖，不同之处在于它是上述也被指定式取代的末端糖残基上的1位氢原子的氢原子。 然而，此外，该寡糖的糖部分的剩余羟基由酰基保护或以未保护的形式存在。 还公开了通过使用硫酸化剂硫酸化合成的寡糖芳香族糖苷硫酸盐的制造方法。

    Alkylated oligosaccharides and acetyl derivatives of the same
    3.
    发明授权
    Alkylated oligosaccharides and acetyl derivatives of the same 失效
    烷基化低聚糖及其乙酰衍生物

    公开(公告)号：US5268461A

    公开(公告)日：1993-12-07

    申请号：US834305

    申请日：1992-02-25

    申请人： Tadao Shoji ,  Nahoko Takahashi ,  Koichiro Adachi ,  Naoya Ikushima ,  Kaname Katsuraya ,  Toshiyuki Uryu ,  Takashi Yoshida

    发明人： Tadao Shoji ,  Nahoko Takahashi ,  Koichiro Adachi ,  Naoya Ikushima ,  Kaname Katsuraya ,  Toshiyuki Uryu ,  Takashi Yoshida

    IPC分类号： C07H3/06 ,  C07H15/04 ,  C07H13/06

    CPC分类号： C07H15/04 ,  C07H3/06

    摘要： An alkylated oligosaccharide and the acetyl derivative of the same, both useful as the raw material for producing lowly toxic surfactants or medicines. The alkylated oligosaccharide is prepared by substituting with an alkyl group having a linear or branched chain the hydrogen atom of the hydroxy group at the 1-position of a terminal sugar moiety of an oligosaccharide in which glucose moieties are .beta.(1.fwdarw.3)-glucoside-linked, or of an oligosaccharide in which galactose is .beta.(1.fwdarw.4)-glycoside-linked at the 4-position in the galactose moiety of lactose and in which galactose moieties are .beta.(1.fwdarw.4)-glycoside-linked in succession to the newly formed terminal galactose moieties. The invention also includes an acetyl derivative of the oligosaccharide, wherein the hydroxy groups excluding the 2-positional hydroxy group adjacent to the alkyl-ether-linking position in the terminal sugar moiety are acetylated, and a mixture thereof. In addition, an acetylated oligosaccharide is allowed to react with an alcohol using a heteropolyacid as the reacting agent.

    摘要翻译： PCT No.PCT / JP91 / 00867 Sec。 371日期：1992年2月25日 102（e）1992年2月25日PCT PCT 1991年6月27日PCT公布。 出版物WO92 / 0031020 日本1992年1月9日。烷基化低聚糖及其乙酰衍生物，均可用作生产低毒性表面活性剂或药物的原料。 烷基化的寡糖通过用直链或支链的烷基取代，其中葡萄糖部分为β（1-> 3） - 寡糖的寡糖的末端糖部分的1-位羟基的氢原子， 葡萄糖苷连接的寡糖或寡聚糖，其中半乳糖是在乳糖的半乳糖部分的4-位上是β（1-> 4） - 糖苷连接的，其中半乳糖部分是β（1-> 4） - 糖苷 - 连接到新形成的末端半乳糖部分。 本发明还包括寡糖的乙酰衍生物，其中不包括与末端糖部分中的烷基 - 醚连接位置相邻的2-位羟基的羟基被乙酰化，以及它们的混合物。 此外，使用杂多酸作为反应剂，使乙酰化寡糖与醇反应。

    Vibration transducer and its manufacturing method
    5.
    发明授权
    Vibration transducer and its manufacturing method 有权
    振动传感器及其制造方法

    公开(公告)号：US09063023B2

    公开(公告)日：2015-06-23

    申请号：US13228855

    申请日：2011-09-09

    申请人： Takashi Yoshida

    发明人： Takashi Yoshida

    IPC分类号： G01L9/08 ,  G01H13/00 ,  G01L9/00 ,  G01L1/10 ,  B81B3/00

    CPC分类号： G01L9/0019 ,  B81B3/001 ,  B81B2201/025 ,  B81B2201/0264 ,  B81B2201/0285 ,  B81B2203/0118 ,  G01L1/106 ,  G01L9/0013 ,  H03H9/2457 ,  H03H2009/02496

    摘要： A vibration transducer includes a silicon single crystal vibration beam provided over a silicon single crystal substrate, the vibration beam having a sectional shape that is longer in a direction perpendicular to a surface of the silicon single crystal substrate than in a direction parallel with it, a shell made of silicon, surrounding the vibration beam with a gap, and forming a vacuum room together with the silicon single crystal substrate, a plate-like first electrode plate disposed parallel with the surface of the silicon single crystal substrate, the first electrode plate having one end connected to the vibration beam, plate-like second and third electrode plates disposed parallel with the surface of the silicon single crystal substrate so as to be opposed to each other with the vibration beam interposed in between, and asperities formed on confronting side surfaces of the vibration beam and the second and third electrode plates.

    摘要翻译： 振动传感器包括设置在硅单晶衬底上的硅单晶振动束，所述振动束具有在垂直于所述硅单晶衬底的表面的方向上比在与其平行的方向上更长的截面形状， 由硅制成的壳体，围绕振动梁间隙，并与硅单晶基板一起形成真空室，与硅单晶基板的表面平行布置的板状第一电极板，第一电极板具有 一端与振动束相连接，板状的第二和第三电极板与硅单晶衬底的表面平行设置，以便彼此相对地插入振动束，并且形成在相对侧面上的凹凸 的振动束和第二和第三电极板。

    Gas fuel injection valve
    6.
    发明授权
    Gas fuel injection valve 有权
    燃气喷射阀

    公开(公告)号：US08899500B2

    公开(公告)日：2014-12-02

    申请号：US13259097

    申请日：2010-03-17

    申请人： Toshinori Kuzuma ,  Takashi Yoshida ,  Wataru Sato ,  Yoji Nakajima

    发明人： Toshinori Kuzuma ,  Takashi Yoshida ,  Wataru Sato ,  Yoji Nakajima

    IPC分类号： F02M61/00 ,  F02M51/00 ,  B05B1/26 ,  F02M61/18 ,  F02M21/02 ,  F02M51/06

    CPC分类号： F02M21/0281 ,  F02M21/0254 ,  F02M21/0266 ,  F02M51/0682 ,  F02M61/1833 ,  F02M61/1846 ,  F02M2200/04 ,  Y02T10/32

    摘要： A gas fuel injection valve is provided in which a single nozzle member (11) is fixedly provided in a front end part of a valve housing (2), and this nozzle member (11) has formed therein a valve seat (13), a valve hole (45) extending through a central part of the valve seat (13), a throttle hole (46) having a smaller diameter than that of the valve hole (45) and communicating with an outlet of the valve hole (45), and a nozzle hole (48) having a larger diameter than that of the throttle hole (46) and communicating with an outlet of the throttle hole (46), wherein when an internal diameter of the throttle hole (46) is D1, a length of the hole (46) is L1, an internal diameter of the nozzle hole (48) is D2, and a length of the nozzle hole (48) is L2, L1/D1>1  (1) 1

    摘要翻译： 提供一种气体燃料喷射阀，其中单个喷嘴构件（11）固定地设置在阀壳体（2）的前端部分中，并且该喷嘴构件（11）中形成有阀座（13）， 延伸穿过阀座（13）的中心部分的阀孔（45），具有小于阀孔（45）的直径的节流孔（46），并与阀孔（45）的出口连通， 以及具有比节流孔（46）的直径大的直径的喷嘴孔（48），并与节流孔（46）的出口连通，其中，当节流孔（46）的内径为D1时， （46）的长度为L1，喷嘴孔（48）的内径为D2，喷嘴孔（48）的长度为L2，L1 / D1> 1（1）1

    Disc changer with detachable optical disc storage magazine for storing multiple optical discs
    7.
    发明授权
    Disc changer with detachable optical disc storage magazine for storing multiple optical discs 有权
    带有可拆卸光盘存储盒的光盘更换器，用于存储多个光盘

    公开(公告)号：US08695024B2

    公开(公告)日：2014-04-08

    申请号：US13034494

    申请日：2011-02-24

    申请人： Takashi Yoshida ,  Osamu Kawamae ,  Yuji Ishikawa

    发明人： Takashi Yoshida ,  Osamu Kawamae ,  Yuji Ishikawa

    IPC分类号： G11B17/22

    CPC分类号： G11B17/30 ,  G11B17/28

    摘要： A magazine detachably installed in a main body of a disc changer is divided into sections by partitions for storing a large number of optical discs. The magazine is provided with a belt set around rollers, which carries the optical disc in contact with the belt. In the disc changer, the belt is rotated by a gear of the roller, which is engaged with an external drive gear for taking the optical disc through rotating movement. Among the optical discs which have been taken, a target optical disc opposite the slit of the disc control plate passes through the slit, and the other optical discs stop while abutting against the disc control plate. The optical disc which has passed through the slit is inserted into disc carriage rollers, and further carried to the drive for recording/reproducing.

    摘要翻译： 可拆卸地安装在盘片更换器的主体中的盒子通过用于存储大量光盘的分区被划分成多个部分。 该盒具有围绕辊子的带组，其带有光盘与带接触。 在换盘器中，皮带通过滚子的齿轮旋转，该齿轮与外部驱动齿轮接合，用于通过旋转运动来取得光盘。 在已经拍摄的光盘中，与盘片控制板的狭缝相对的目标光盘通过狭缝，另一个光盘在与盘控制板抵接的同时停止。 已经通过狭缝的光盘被插入到盘托架辊中，并进一步传送到驱动器进行记录/再现。

    Control device
    8.
    发明授权
    Control device 有权
    控制装置

    公开(公告)号：US08663062B2

    公开(公告)日：2014-03-04

    申请号：US13565296

    申请日：2012-08-02

    申请人： Hideya Kawai ,  Takashi Yoshida

    发明人： Hideya Kawai ,  Takashi Yoshida

    IPC分类号： B60W10/08

    CPC分类号： B60K6/48 ,  B60K6/547 ,  B60K2006/4825 ,  B60L11/005 ,  B60L11/14 ,  B60L15/20 ,  B60L2210/40 ,  B60L2240/421 ,  B60L2240/423 ,  B60L2240/441 ,  B60L2240/443 ,  B60L2240/507 ,  B60W10/02 ,  B60W10/06 ,  B60W10/08 ,  B60W20/40 ,  B60W2510/0241 ,  B60W2710/027 ,  B60Y2300/429 ,  Y02T10/6221 ,  Y02T10/6252 ,  Y02T10/6286 ,  Y02T10/645 ,  Y02T10/70 ,  Y02T10/7022 ,  Y02T10/7077 ,  Y02T10/7241 ,  Y02T10/7275 ,  Y10T477/26

    摘要： A control device for controlling a vehicle drive device includes a rotary electric machine in a transmission path connecting a combustion engine with wheels; a first friction engagement device between the combustion engine and the rotary machine; and a second friction engagement device between the rotary machine and wheels. The control device shifts the first and second engagement devices from a state in which the first engagement device is disengaged and the second engagement device is in direct engagement so that force is transmitted between the rotary machine and wheels, to a state in which force is transmitted at least between the combustion engine and wheels, by shifting the second engagement device from direct engagement to a slip state and thereafter shifting the first engagement device from disengaged to engaged. After the state is changed, the control device shifts the second engagement device from slip engagement to direct engagement.

    摘要翻译： 用于控制车辆驱动装置的控制装置包括：连接内燃机与车轮的传动路径中的旋转电机; 在内燃机和旋转机器之间的第一摩擦接合装置; 以及旋转机器和轮子之间的第二摩擦接合装置。 控制装置从第一接合装置分离的状态和第二接合装置直接接合的状态移动第一接合装置和第二接合装置，使得力在旋转机械和轮之间传递到传递力的状态 至少在内燃机和车轮之间，通过将第二接合装置从直接接合移动到滑动状态，然后将第一接合装置从脱离转换到接合。 在状态改变之后，控制装置将第二接合装置从滑动接合转移到直接接合。