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公开(公告)号：US06297028B1
公开(公告)日：2001-10-02
申请号：US08860656
申请日：1998-01-15
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： The present invention relates to a polypeptide, p43, which is associated with the interleukin-2 receptor (IL-2R). It binds specifically to the &bgr; and &ggr; subunits of IL-2R and is further capable of binding NAD+. The invention is further related to nucleic acid molecules coding for p43 and to antibodies specifically binding to p43.
摘要翻译： 本发明涉及与白细胞介素-2受体（IL-2R）相关的多肽p43。 它特异性结合IL-2R的β和γ亚基，并且还能够结合NAD +。 本发明还涉及编码p43的核酸分子和与p43特异性结合的抗体。
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公开(公告)号：US20080317766A1
公开(公告)日：2008-12-25
申请号：US12128658
申请日：2008-05-29
IPC分类号： A61K39/395 , C07K14/435 , A61K39/00 , C07K16/00
CPC分类号： C07K14/4703 , C07K16/18
摘要： The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.
摘要翻译： 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外，本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。
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3.发明授权D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture 有权D-吡喃糖基取代的苯基衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US07419959B2
公开(公告)日：2008-09-02
申请号：US11239917
申请日：2005-09-30
IPC分类号： A61K31/70 , A61K31/351 , C07H7/06 , C07D309/10
CPC分类号： C07H7/04
摘要： D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
摘要翻译： D-吡喃糖基取代的通式I的苯基，其中基团R 1至R 5，X，Z和R 7a，R SUP 如权利要求1所定义，R 7，R 7c对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用。 本发明还涉及用于治疗代谢紊乱的药物组合物。
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4.发明授权Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof 有权吡喃葡糖基氧基 - 吡唑，含有这些化合物的药物组合物，其用途及其制备方法公开(公告)号：US07375090B2
公开(公告)日：2008-05-20
申请号：US10925656
申请日：2004-08-24
CPC分类号： C07H17/02
摘要： The present invention relates to glucopyranosyloxy-pyrazoles of general formula wherein R1 to R6 and R7a, R7b, R7c are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids, which have valuable pharmacological properties, particularly an inhibitory effect on sodium-dependent glucose cotransporter SGLT, the use thereof for the treatment of diseases, particularly metabolic disorders such as diabetes, and the preparation thereof.
摘要翻译： 本发明涉及以下通式的吡喃葡萄糖基氧基 - 吡唑：其中R 1至R 6，R 7a，R 7b， > R 7，如权利要求1中所定义，互变异构体，立体异构体，其混合物及其盐，特别是其与无机或有机酸的生理上可接受的盐，其具有有价值的药理学性质， 特别是对钠依赖性葡萄糖协同转运体SGLT的抑制作用，其用于治疗疾病，特别是糖尿病等代谢性疾病的用途及其制备。
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5.发明授权D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture 有权D-吡喃木糖基 - 苯基取代的周期，含有这些化合物的药物，它们的用途和制造方法公开(公告)号：US07417032B2
公开(公告)日：2008-08-26
申请号：US11190315
申请日：2005-07-27
CPC分类号： C07H7/04 , C07D309/10 , C07D309/12 , C07D309/22 , C07D405/10 , C07D405/12 , C07D407/10 , C07D407/12
摘要： D-Glucopyranosyl-phenyl-substituted cycles of general formula I wherein the groups R1 to R6, Z, Cy and R7a, R7b, R7c, R7d are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
摘要翻译： 通式I的D-吡喃葡糖基 - 苯基取代的环，其中基团R 1至R 6，Z，Cy和R 7a，R R 7，R 7，R 7，R 7，如权利要求1中所定义，对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用。 本发明还涉及用于治疗代谢紊乱的药物组合物。
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6.发明授权Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡萄糖基取代的苯衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US07687469B2
公开(公告)日：2010-03-30
申请号：US11304284
申请日：2005-12-15
IPC分类号： A61K31/7004 , C07H7/04
CPC分类号： C07H7/04
摘要： Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 根据权利要求1所述的吡喃葡萄糖基取代的苯衍生物，包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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7.发明授权D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture 有权D-吡喃木糖基取代的苯基衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US07393836B2
公开(公告)日：2008-07-01
申请号：US11168905
申请日：2005-06-28
摘要： A D-Xylopyranosyl-substituted phenyl compound of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
摘要翻译： 通式I的D-吡喃葡萄糖基取代的苯基化合物，其中基团R 1至R 5，X，Z和R 7a，R 如权利要求1中所定义，R 7，R 7c对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用。 本发明还涉及用于治疗代谢紊乱的药物组合物。
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8.发明授权Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的（（杂）芳基乙炔基 - 苄基） - 苯衍生物，含有这些化合物的药物，它们的用途和制造方法公开(公告)号：US07772378B2
公开(公告)日：2010-08-10
申请号：US11359846
申请日：2006-02-22
IPC分类号： A61K31/351 , A61K31/7004 , C07H7/04 , C07D367/20
CPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R 1至R 6以及R 7a，R 7b，R 7c根据权利要求1定义的通式I的吡喃葡糖基取代的（杂）芳基乙炔基 - 苯衍生物，包括互变异构体，其立体异构体，其混合物和盐 其中。 根据本发明的化合物适用于治疗代谢性疾病。
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9.发明授权Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的苯基衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US07579449B2
公开(公告)日：2009-08-25
申请号：US11080150
申请日：2005-03-15
IPC分类号： A61K31/70 , A61K31/7004 , A61K31/351 , C07H7/04 , C07H309/10
CPC分类号： C07H23/00 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10 , C07H15/04 , C07H15/20 , C07H15/26
摘要： Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R 1至R 6以及R 7a，R 7b，R 7c在本文中定义的通式I的吡喃葡糖基取代的苯衍生物以及互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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10.发明申请GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 审中-公开含有这些化合物的葡萄糖苷取代的苯甲酸衍生物，其使用方法及其制造方法公开(公告)号：US20090023913A1
公开(公告)日：2009-01-22
申请号：US12207722
申请日：2008-09-10
IPC分类号： C07H15/04
CPC分类号： C07H23/00 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10 , C07H15/04 , C07H15/20 , C07H15/26
摘要： Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R 1至R 6以及R 7a，R 7b，R 7c在本文中定义的通式I的吡喃葡糖基取代的苯衍生物以及互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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