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    Cell aggregation and encapsulation device and method
    2.
    发明授权
    Cell aggregation and encapsulation device and method 有权
    细胞聚集和封装装置及方法

    公开(公告)号：US08361781B2

    公开(公告)日：2013-01-29

    申请号：US12087937

    申请日：2007-01-24

    申请人： Jeffrey Morgan ,  Anthony Napolitano

    发明人： Jeffrey Morgan ,  Anthony Napolitano

    IPC分类号： C40B50/06 ,  C40B60/00 ,  C12M1/00 ,  C12N5/00 ,  B29C33/40

    CPC分类号： C12M25/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M23/12 ,  C12M25/14 ,  C12N5/0012 ,  C12N5/0062 ,  C12N2533/40 ,  C12N2533/74

    摘要： The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.

    摘要翻译： 本发明是一种细胞聚集装置，其包括具有至少一个，优选多个凹陷到最上表面的细胞排斥隔室的水凝胶基底。 每个隔室由具有开口最上部分和底部的上部细胞悬浮播种室组成，以及通过端口连接到上部细胞悬浮播种室的底部的一个或多于一个下部细胞聚集凹部。 端口的直径可以与腔室的壁和凹部的壁完全邻接，或者端口的直径可以比室的壁更窄，但是与凹部的壁完全邻接或更窄 房间的墙壁和凹槽的墙壁。 形成并定位上细胞悬浮播种室，以通过重力将细胞漏入下细胞聚集凹槽。 形成和定位聚集凹槽以通过将细胞聚结成最小引力能的有限区域，增加细胞间接触并最小化或防止细胞粘附于基底来促进细胞聚集。 提供了用于封装活细胞聚集体的装置。 所述装置包括（i）生物相容的生物可持续的底物，其具有由一个或多个生物相容性，生物可持续的间隔开的细胞包封的隔室组成的细胞封装面，所述细胞封装的区域从其延伸，和（ii）由 生物相容的，生物可持续的聚合物，其完全包围底物和细胞封装隔室。 还提供了制造该装置的方法。

    Personal care compositions that deposit sunless tanning benefit agents
    3.
    发明申请
    Personal care compositions that deposit sunless tanning benefit agents 审中-公开
    个人护理组合物，可以保存阳光晒黑效果剂

    公开(公告)号：US20050238595A1

    公开(公告)日：2005-10-27

    申请号：US11103253

    申请日：2005-04-11

    申请人： Qing Stella ,  Jeffrey Morgan ,  Steven Page ,  Mark Kacher ,  Karl Wei ,  Magda El-Nokaly

    发明人： Qing Stella ,  Jeffrey Morgan ,  Steven Page ,  Mark Kacher ,  Karl Wei ,  Magda El-Nokaly

    IPC分类号： A61K8/35 ,  A61K8/73 ,  A61Q19/00 ,  A61Q19/04 ,  A61K7/42

    CPC分类号： A61Q19/04 ,  A61K8/35 ,  A61K8/737 ,  A61K2800/5426

    摘要： A personal care composition that comprises a sunless tanning active, a surface active, a lipid, and an aqueous phase; wherein the lipid, the sunless tanning active, and the surface active form a lipid phase; wherein the sunless tanning active and the surface active are on the surface of the lipid, within the domain of the lipid, or both on the surface and within the domain of the lipid in the lipid phase. These compositions deposit sunless tanning actives on keratinous surfaces as well as provide improved skin moisturization, appearance, aesthetics and skin feel during and/or after application. The present invention is further directed to a method of using the personal care composition.

    摘要翻译： 一种个人护理组合物，其包含无阳光鞣制活性物质，表面活性剂，脂质和水相; 其中所述脂质，所述无阳光鞣制活性物质和所述表面活性物形成脂质相; 其中无阳光鞣制活性物质和表面活性物质位于脂质表面，脂质结构域内，或脂质相中表面上和脂质结构域内。 这些组合物将晒黑鞣制活性物质沉积在角质表面上，并且在施用期间和/或施用后提供改善的皮肤保湿，外观，美观和皮肤感觉。 本发明还涉及一种使用个人护理组合物的方法。

    Hydroxyapatite backed glenoid prosthesis
    4.
    发明申请
    Hydroxyapatite backed glenoid prosthesis 审中-公开
    羟基磷灰石支持关节盂假体

    公开(公告)号：US20060122705A1

    公开(公告)日：2006-06-08

    申请号：US11294799

    申请日：2005-12-05

    申请人： Jeffrey Morgan

    发明人： Jeffrey Morgan

    IPC分类号： A61F2/40

    CPC分类号： A61F2/4081 ,  A61F2002/30878 ,  A61F2002/30879 ,  A61F2002/30892 ,  A61F2310/00293 ,  A61F2310/00796

    摘要： A glenoid prosthesis for use in total shoulder arthroplasty. The glenoid prosthesis has a concave articulating plate that can interact with the humeral component of an artificial shoulder joint, and a backing for connecting and bonding the prosthesis to the human scapula. The backing of the glenoid prosthesis can be made using hydroxyapatite, which forms a bond with human bone. The backing can further include means for connecting, such as pegs or a keel, to facilitate the connection of the glenoid prosthesis with the scapula.

    摘要翻译： 用于全肩关节置换术的关节盂假体。 关节盂假体具有能够与人造肩关节的肱骨部件相互作用的凹形关节板，以及用于将假体连接并连接到人体肩胛骨的背衬。 关节盂假体的背衬可以使用与人骨形成结合的羟基磷灰石制成。 背衬还可以包括用于连接的装置，例如钉或龙骨，以便于关节盂假体与肩胛骨的连接。

    Spontaneous sharing of media asset references
    5.
    发明申请
    Spontaneous sharing of media asset references 有权

    公开(公告)号：US20060095337A1

    公开(公告)日：2006-05-04

    申请号：US10979014

    申请日：2004-10-31

    申请人： Jeffrey Morgan

    发明人： Jeffrey Morgan

    IPC分类号： G06Q30/00

    CPC分类号： G06Q30/06 ,  G06Q30/02 ,  G06Q30/0601

    摘要： A solution for spontaneous sharing between a sharer and a recipient device of a media asset reference for a media asset purchased through a media service by a user of the sharer device using a short-range wireless protocol is described. The reference includes a network resolvable identifier of a media service from which the media asset was purchased and an identifier of the media asset. The reference can also include the identity of the user who purchased and is sharing the reference thus allowing the media service to track distribution of its asset and provide an incentive based on sharing if desired when the recipient user sends a request for the media asset via the Internet to the media service including the media asset reference.

    Cell Aggregation and Encapsulation Device and Method
    7.
    发明申请
    Cell Aggregation and Encapsulation Device and Method 有权
    细胞聚集和包封装置及方法

    公开(公告)号：US20090018033A1

    公开(公告)日：2009-01-15

    申请号：US12087937

    申请日：2007-01-24

    申请人： Jeffrey Morgan ,  Peter Chai ,  Anthony Napolitano ,  Edith Mathiowitz ,  Dylan Dean

    发明人： Jeffrey Morgan ,  Peter Chai ,  Anthony Napolitano ,  Edith Mathiowitz ,  Dylan Dean

    IPC分类号： C40B50/06 ,  C12M1/00 ,  C12N5/00 ,  B29C33/40 ,  C40B60/00

    CPC分类号： C12M25/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M23/12 ,  C12M25/14 ,  C12N5/0012 ,  C12N5/0062 ,  C12N2533/40 ,  C12N2533/74

    摘要： The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber having an open uppermost portion and a bottom portion, and one, or more than one, lower cell aggregation recess connected to the bottom portion of the upper cell suspension seeding chamber by a port. The diameter of the port may be fully contiguous with the walls of the chambers and walls of the recesses, or the diameter of the port may be more narrow than the walls of the chamber but fully contiguous with the walls of the recesses or more narrow than both the walls of the chamber and the walls of the recesses. The upper cell suspension seeding chambers are formed and positioned to funnel the cells into the lower cell aggregation recesses through gravitational force. The aggregation recesses are formed and positioned to promote cellular aggregation by coalescing cells into a finite region of minimum gravitational energy, increasing intercellular contact and minimizing or preventing cell adherence to the substrate. A device for encapsulating aggregates of live cells is provided. The device comprises (i) a biocompatible, bio-sustainable substrate having a cell-encapsulating face composed of one or more biocompatible, bio-sustainable, spaced-apart, cell-encapsulating compartments extending therefrom and (ii) a coating layer composed of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and the cell-encapsulating compartments. A method for making the device is also provided.

    摘要翻译： 本发明是一种细胞聚集装置，其包括具有至少一个，优选多个凹陷到最上表面的细胞排斥隔室的水凝胶基底。 每个隔室由具有开口最上部分和底部的上部细胞悬浮播种室组成，以及通过端口连接到上部细胞悬浮播种室的底部的一个或多于一个下部细胞聚集凹部。 端口的直径可以与腔室的壁和凹部的壁完全邻接，或者端口的直径可以比室的壁更窄，但是与凹部的壁完全邻接或更窄 房间的墙壁和凹槽的墙壁。 形成并定位上细胞悬浮播种室，以通过重力将细胞漏入下细胞聚集凹槽。 形成和定位聚集凹槽以通过将细胞聚结成最小引力能的有限区域，增加细胞间接触并最小化或防止细胞粘附于基底来促进细胞聚集。 提供了用于封装活细胞聚集体的装置。 所述装置包括（i）生物相容的生物可持续的底物，其具有由一个或多个生物相容性，生物可持续的间隔开的细胞包封的隔室组成的细胞封装面，所述细胞封装的区域从其延伸，和（ii）由 生物相容的，生物可持续的聚合物，其完全包围底物和细胞封装隔室。 还提供了制造该装置的方法。

    Throttle control method and apparatus
    8.
    发明申请
    Throttle control method and apparatus 有权
    节气门控制方法和装置

    公开(公告)号：US20060201483A1

    公开(公告)日：2006-09-14

    申请号：US11373045

    申请日：2006-03-09

    申请人： John Herrick ,  Fred Yates ,  Jeffrey Morgan ,  Edward Ramsden

    发明人： John Herrick ,  Fred Yates ,  Jeffrey Morgan ,  Edward Ramsden

    IPC分类号： F02D11/10

    CPC分类号： F02D11/02 ,  B60K26/02 ,  F02D11/106 ,  F02D2200/602 ,  F02D2400/08

    摘要： A throttle control device for transmitting signals to an electronic fuel control system for a vehicle engine is provided that includes an electromagnetic field generator and first and second electromagnetic field sensors positioned proximal to electromagnetic field. The electromagnetic field and the first and second sensors being manipulatable relative to each other, and the sensors being responsive to the relative manipulation. The sensors configured to independently transmit signals representative of said relative manipulation.

    摘要翻译： 提供一种用于将信号发送到用于车辆发动机的电子燃料控制系统的节气门控制装置，其包括电磁场发生器和位于电磁场附近的第一和第二电磁场传感器。 电磁场和第一和第二传感器可相对于彼此操纵，并且传感器响应于相对操纵。 所述传感器被配置为独立地发送代表所述相对操纵的信号。

    Methods for removal, purification, and concentration of viruses and methods of therapy based thereupon
    10.
    发明申请
    Methods for removal, purification, and concentration of viruses and methods of therapy based thereupon 有权
    病毒的去除，纯化和浓缩方法及其治疗方法

    公开(公告)号：US20050247630A1

    公开(公告)日：2005-11-10

    申请号：US11018939

    申请日：2004-12-21

    申请人： William Lee ,  Jeffrey Morgan ,  Martin Yarmush

    发明人： William Lee ,  Jeffrey Morgan ,  Martin Yarmush

    IPC分类号： A61L2/00 ,  C12N7/02 ,  C12Q1/68 ,  B01D61/00 ,  C02F1/44

    CPC分类号： C12N7/00 ,  A61L2/0017 ,  A61L2/0082 ,  C12N2740/10051

    摘要： The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.

    摘要翻译： 本发明基于以下发现：包括侧链的某些膜或具有例如叔氨基官能团的分子“刷”可用作高效过滤器，以从液体中捕获病毒/病毒颗粒而不除去蛋白质。 基于该发现的新方法包括从诸如血液或血浆的液体中除去病毒，从药物中除去病毒，浓缩和/或纯化病毒，例如用于基因治疗，以及在新的生物反应器中产生重组病毒。 本发明还包括用于病毒感染的新的治疗方法或辅助治疗方法，其中通过膜过滤患者的血液或血浆以除去病毒以减少病毒载量。 本发明还包括含有膜的新的生物反应器和病毒过滤器。