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    2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors
    1.
    发明授权
    2,7-substituted thieno[3,2-d] pyrimidine compounds as protein kinase inhibitors 失效
    2,7-取代的噻吩并[3,2-d]嘧啶化合物作为蛋白激酶抑制剂

    公开(公告)号：US08586580B2

    公开(公告)日：2013-11-19

    申请号：US13503125

    申请日：2010-10-15

    申请人： Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Young Jin Ham ,  Eun Jin Jun ,  Jung Hun Lee ,  Hwan Kim

    发明人： Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Young Jin Ham ,  Eun Jin Jun ,  Jung Hun Lee ,  Hwan Kim

    IPC分类号： C07D495/04 ,  C07D495/02 ,  A61K31/505 ,  A61P35/00

    CPC分类号： C07D495/04 ,  C07D519/00

    摘要： Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

    摘要翻译： 公开了具有蛋白激酶抑制活性的2,7-取代的噻吩并[3,2-d]嘧啶化合物，药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其包含作为 有效成分。 由于新的2,7-取代的噻吩并[3,2-d]嘧啶化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗异常细胞生长引起的疾病的药剂。

    2,7-SUBSTITUTED THIENO[3,2-D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
    2.
    发明申请
    2,7-SUBSTITUTED THIENO[3,2-D] PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 失效
    2,7-取代的噻吩并[3,2-D]吡啶化合物作为蛋白激酶抑制剂

    公开(公告)号：US20120277424A1

    公开(公告)日：2012-11-01

    申请号：US13503125

    申请日：2010-10-15

    申请人： Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Young Jin Ham ,  Eun Jin Jun ,  Jung Hun Lee ,  Hwan Kim

    发明人： Tae Bo Sim ,  Hwan Geun Choi ,  Jung Mi Hah ,  Young Jin Ham ,  Eun Jin Jun ,  Jung Hun Lee ,  Hwan Kim

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04 ,  C07D519/00

    摘要： Disclosed are a 2,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel 2,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

    摘要翻译： 公开了具有蛋白激酶抑制活性的2,7-取代的噻吩并[3,2-d]嘧啶化合物，药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其包含作为 有效成分。 由于新的2,7-取代的噻吩并[3,2-d]嘧啶化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗异常细胞生长引起的疾病的药剂。

    2,4,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS
    6.
    发明申请
    2,4,7-SUBSTITUTED THIENO[3,2-D]PYRIMIDINE COMPOUNDS AS PROTEIN KINASE INHIBITORS 有权
    作为蛋白激酶抑制剂的2,4,7-取代的三[3,2-D]吡啶化合物

    公开(公告)号：US20130012703A1

    公开(公告)日：2013-01-10

    申请号：US13510743

    申请日：2010-10-22

    申请人： Tae Bo Sim ,  Jung Mi Hah ,  Hwan Geun Choi ,  Young Jin Ham ,  Jung Hun Lee ,  Dong Sik Park ,  Hwan Kim

    发明人： Tae Bo Sim ,  Jung Mi Hah ,  Hwan Geun Choi ,  Young Jin Ham ,  Jung Hun Lee ,  Dong Sik Park ,  Hwan Kim

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： Disclosed are a 2,4,7-substituted thieno[3,2-d]pyrimidine compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of diseases caused by abnormal cell growth comprising the compound as an effective ingredient.Since the novel 2,4,7-substituted thieno[3,2-d]pyrimidine compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating diseases caused by abnormal cell growth.

    摘要翻译： 公开了具有蛋白激酶抑制活性的2,4,7-取代噻吩并[3,2-d]嘧啶化合物，药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其包含化合物 作为有效成分。 由于新的2,4,7-取代噻吩并[3,2-d]嘧啶化合物对参与生长因子信号转导的各种蛋白激酶具有优异的抑制活性，因此可用作预防或治疗由异常细胞引起的疾病 成长。