公开(公告)号：US20050239120A1

公开(公告)日：2005-10-27

申请号：US11114070

申请日：2005-04-26

申请人： Tae-sik Park ,  Jung-ho Kang ,  Jong-hwa Won ,  Young-il Kim ,  Moon-chul Lee

发明人： Tae-sik Park ,  Jung-ho Kang ,  Jong-hwa Won ,  Young-il Kim ,  Moon-chul Lee

IPC分类号： G01N22/00 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/02 ,  G01N27/22 ,  G01N27/327 ,  G01N33/543 ,  G01R33/00

CPC分类号： G01N27/3275 ,  G01N33/48792

摘要： An apparatus and method of detecting bio molecular by measuring a variation of an electrical characteristic of a circuit having an inductance device and a capacitance device. The bio molecular detection method comprises providing a signal converting unit having at least one inductance device and at least one capacitance device connected with each other, disposing a biochip, which has capturing probe biomolecules attached to a substrate, at a location in the signal converting unit, and measuring an electrical characteristic of the signal converting unit, performing a coupling reaction of the biochip and a sample to be analyzed; and measuring an electrical characteristic of the signal converting unit after the coupling reaction.

摘要翻译： 通过测量具有电感器件和电容器件的电路的电特性的变化来检测生物分子的装置和方法。 所述生物分子检测方法包括提供信号转换单元，所述信号转换单元具有至少一个电感器件和至少一个电容器件，所述至少一个电容器件彼此连接，在所述信号转换单元中的位置处设置生物芯片，所述生物芯片具有连接到衬底的捕获探针生物分子 测量信号转换单元的电特性，进行生物芯片与待分析样品的偶联反应; 并测量耦合反应后的信号转换单元的电特性。

公开(公告)号：US20110020140A1

公开(公告)日：2011-01-27

申请号：US11266903

申请日：2005-11-04

申请人： Tae-sik Park ,  Young-il Kim ,  Jung-ho Kang ,  Moon-chul Lee

发明人： Tae-sik Park ,  Young-il Kim ,  Jung-ho Kang ,  Moon-chul Lee

IPC分类号： F04B37/02

CPC分类号： F04B19/006 ,  F04B43/043

摘要： Provided is a micro pump having a simple structure. The micro pump includes a pump chamber including inflow and outflow passages through which a drive fluid flows, a first valve configured to open or close the inflow passage, a second valve configured to open or close the outflow passage, and a pump chamber heating and cooling unit configured to heat or cool the pump chamber.

摘要翻译： 提供一种结构简单的微型泵。 微型泵包括泵室，其包括驱动流体流过的流入和流出通道，构造成打开或关闭流入通道的第一阀，构造成打开或关闭流出通道的第二阀，以及泵室加热和冷却 单元被配置为加热或冷却泵室。

公开(公告)号：US20060018801A1

公开(公告)日：2006-01-26

申请号：US11188000

申请日：2005-07-25

申请人： Tae-sik Park ,  Sung-hee Lee ,  Jung-ho Kang ,  Young-il Kim ,  Moon-chul Lee

发明人： Tae-sik Park ,  Sung-hee Lee ,  Jung-ho Kang ,  Young-il Kim ,  Moon-chul Lee

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/049 ,  B01L2400/049 ,  B01L2400/06

摘要： A bio sample processing apparatus and method using vacuum chambers in which a bio sample is injected into a first vacuum chamber connected with one end of a bio processor and, after processing, is ejected into a second vacuum chamber connected with the other end of the bio processor. The vacuum chambers and bio processor are connected with each other to form an environment with a pressure lower than atmospheric pressure, and the bio sample moves toward the second vacuum chamber due to the pressure difference created by the injection of the bio sample into the first vacuum chamber.

摘要翻译： 一种使用真空室的生物样品处理装置和方法，其中将生物样品注入与生物处理器的一端连接的第一真空室中，并且在处理之后被喷射到与生物的另一端连接的第二真空室中 处理器。 真空室和生物处理器彼此连接以形成压力低于大气压的环境，并且生物样品由于将生物样品注入第一真空产生的压差而向第二真空室移动 房间。

公开(公告)号：US20060073502A1

公开(公告)日：2006-04-06

申请号：US11225507

申请日：2005-09-13

申请人： Sung-hee Lee ,  Jung-ho Kang ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

发明人： Sung-hee Lee ,  Jung-ho Kang ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： G01N33/5438 ,  G01N33/553

摘要： An apparatus and method for detecting a bio-bonding includes monitoring of a change of an electrical property before and after bio-bonding. The apparatus includes a signal transducer section having a substrate, a metallic thin film stepped on a surface of a certain region of the substrate, probe biomolecules formed on the metallic thin film, an input port connected with one side of the signal transducer section and into which a signal for monitoring an electrical property of the signal transducer section is input and a detector section for characteristic quantity connected with the other side of the signal transducer section so as to monitor an electrical property of the signal transducer section. The probe biomolecules are immobilized on the metallic thin film. The bio-bonding is detected through monitoring the electrical property of the signal transducer section before and after the bio-bonding.

摘要翻译： 用于检测生物粘合的装置和方法包括监测生物粘合之前和之后的电特性的变化。 该装置包括：信号传感器部，具有基板，在基板的特定区域的台阶上阶梯状的金属薄膜，形成在金属薄膜上的探针生物分子，与信号换能器部的一侧连接的输入口， 输入用于监视信号换能器部分的电气性能的信号，以及用于与信号换能器部分的另一侧连接的特征量的检测器部分，以监测信号换能器部分的电气特性。 探针生物分子固定在金属薄膜上。 通过在生物粘合之前和之后监测信号传感器部分的电性能来检测生物粘合。

公开(公告)号：US07896621B2

公开(公告)日：2011-03-01

申请号：US11266903

申请日：2005-11-04

申请人： Tae-sik Park ,  Young-il Kim ,  Jung-ho Kang ,  Moon-chul Lee

发明人： Tae-sik Park ,  Young-il Kim ,  Jung-ho Kang ,  Moon-chul Lee

IPC分类号： F04B19/24

CPC分类号： F04B19/006 ,  F04B43/043

摘要： Provided is a micro pump having a simple structure. The micro pump includes a pump chamber including inflow and outflow passages through which a drive fluid flows, a first valve configured to open or close the inflow passage, a second valve configured to open or close the outflow passage, and a pump chamber heating and cooling unit configured to heat or cool the pump chamber.

摘要翻译： 提供一种结构简单的微型泵。 微型泵包括泵室，其包括驱动流体流过的流入和流出通道，构造成打开或关闭流入通道的第一阀，构造成打开或关闭流出通道的第二阀，以及泵室加热和冷却 单元被配置为加热或冷却泵室。

公开(公告)号：US07785864B2

公开(公告)日：2010-08-31

申请号：US11184894

申请日：2005-07-20

申请人： Jung-ho Kang ,  Sung-hee Lee ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

发明人： Jung-ho Kang ,  Sung-hee Lee ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

IPC分类号： C12M1/34 ,  C12M3/00 ,  C12M1/00

CPC分类号： G01N27/3276 ,  G01N29/036

摘要： Provided are a bio-molecules detecting apparatus using electromagnetic induction and a detecting method using the same. An exemplary apparatus includes: a cantilever of which one end is fixed and the other end is set up to be movable; a first metal formed on a plane of the cantilever and receiving a signal; a bio chip formed in the first metal and having probe biomolecules for searching particular information on a sample to be analyzed; an electromagnetic inductor configured to form a magnetic field; a signal source for applying the signal to the first metal; and a detector for measuring signal values of the first metal before and after the biomolecule is coupled with the sample. The apparatus detects the bio-couple by converting a change in mechanical properties before and after the bio-coupling based on electromagnetic induction to detect a bio-couple.

摘要翻译： 提供了使用电磁感应的生物分子检测装置和使用其的检测方法。 一种示例性装置包括：其一端被固定并且另一端被设置为可移动的悬臂; 形成在悬臂的平面上并接收信号的第一金属; 在第一金属中形成的生物芯片，并具有用于搜索待分析样品的特定信息的探针生物分子; 构造成形成磁场的电磁感应器; 用于将信号施加到第一金属的信号源; 以及用于测量生物分子之前和之后第一金属的信号值与检测器结合的检测器。 该装置通过基于电磁感应转换生物耦合之前和之后的机械特性的变化来检测生物耦合，以检测生物耦合。

公开(公告)号：US07764070B2

公开(公告)日：2010-07-27

申请号：US11114070

申请日：2005-04-26

申请人： Tae-sik Park ,  Jung-ho Kang ,  Jong-hwa Won ,  Young-il Kim ,  Moon-chul Lee

发明人： Tae-sik Park ,  Jung-ho Kang ,  Jong-hwa Won ,  Young-il Kim ,  Moon-chul Lee

IPC分类号： G01R27/26 ,  C12Q1/68 ,  C12M1/34 ,  G01N27/26 ,  G01N27/00 ,  C02F1/40

CPC分类号： G01N27/3275 ,  G01N33/48792

摘要： An apparatus and method of detecting bio molecular by measuring a variation of an electrical characteristic of a circuit having an inductance device and a capacitance device. The bio molecular detection method comprises providing a signal converting unit having at least one inductance device and at least one capacitance device connected with each other, disposing a biochip, which has capturing probe biomolecules attached to a substrate, at a location in the signal converting unit, and measuring an electrical characteristic of the signal converting unit, performing a coupling reaction of the biochip and a sample to be analyzed; and measuring an electrical characteristic of the signal converting unit after the coupling reaction.

摘要翻译： 通过测量具有电感器件和电容器件的电路的电特性的变化来检测生物分子的装置和方法。 所述生物分子检测方法包括提供信号转换单元，所述信号转换单元具有至少一个电感器件和至少一个电容器件，所述至少一个电容器件彼此连接，在所述信号转换单元中的位置处设置生物芯片，所述生物芯片具有连接到衬底的捕获探针生物分子 测量信号转换单元的电特性，进行生物芯片与待分析样品的偶联反应; 并测量耦合反应后的信号转换单元的电特性。

公开(公告)号：US07741105B2

公开(公告)日：2010-06-22

申请号：US11329240

申请日：2006-01-10

申请人： Young-il Kim ,  Moon-chul Lee ,  Jung-ho Kang ,  Tae-sik Park

发明人： Young-il Kim ,  Moon-chul Lee ,  Jung-ho Kang ,  Tae-sik Park

IPC分类号： B81B7/04

CPC分类号： G01N33/544

摘要： Disclosed is a biomolecule chip and a fabrication method thereof. The biomolecule chip of the invention includes: a substrate; an insulating layer formed on the substrate; an adhesive layer formed on the insulating layer; a seed layer formed on the adhesive layer; an opening patterned at a predetermined location within the adhesive layer, the seed layer and the electroplating layer; and a biomolecule immobilized layer formed on the electroplating layer, the electroplating layer comprising a plasma-treated electroplating layer prior to the formation of the biomolecule immobilized layer. Accordingly, the immobilization of biomolecules onto the surface can be done more effectively by modifying the surface of the substrate in favor of biomolecules.

摘要翻译： 公开了一种生物分子芯片及其制造方法。 本发明的生物分子芯片包括：基材; 形成在所述基板上的绝缘层; 形成在所述绝缘层上的粘合剂层; 形成在粘合剂层上的种子层; 在粘合剂层内的预定位置图案化的开口，种子层和电镀层; 以及形成在所述电镀层上的生物分子固定层，所述电镀层在形成所述生物分子固定化层之前包含等离子体处理的电镀层。 因此，通过改变基质表面有利于生物分子，可以更有效地进行生物分子固定在表面上。

公开(公告)号：US20060154242A1

公开(公告)日：2006-07-13

申请号：US11329240

申请日：2006-01-10

申请人： Young-il Kim ,  Moon-chul Lee ,  Jung-ho Kang ,  Tae-sik Park

发明人： Young-il Kim ,  Moon-chul Lee ,  Jung-ho Kang ,  Tae-sik Park

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  H01L21/00

CPC分类号： G01N33/544

摘要： Disclosed is a biomolecule chip and a fabrication method thereof The biomolecule chip of the invention includes: a substrate; an insulating layer formed on the substrate; an adhesive layer formed on the insulating layer; a seed layer formed on the adhesive layer; an opening patterned at a predetermined location within the adhesive layer, the seed layer and the electroplating layer; and a biomolecule immobilized layer formed on the electroplating layer, the electroplating layer comprising a plasma-treated electroplating layer prior to the formation of the biomolecule immobilized layer. Accordingly, the immobilization of biomolecules onto the surface can be done more effectively by modifying the surface of the substrate in favor of biomolecules.

摘要翻译： 公开了一种生物分子芯片及其制造方法。本发明的生物分子芯片包括：基板; 形成在所述基板上的绝缘层; 形成在所述绝缘层上的粘合剂层; 形成在粘合剂层上的种子层; 在粘合剂层内的预定位置图案化的开口，种子层和电镀层; 以及形成在所述电镀层上的生物分子固定层，所述电镀层在形成所述生物分子固定化层之前包含等离子体处理的电镀层。 因此，通过改变基质表面有利于生物分子，可以更有效地进行生物分子固定在表面上。

公开(公告)号：US20060019299A1

公开(公告)日：2006-01-26

申请号：US11184894

申请日：2005-07-20

申请人： Jung-ho Kang ,  Sung-hee Lee ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

发明人： Jung-ho Kang ,  Sung-hee Lee ,  Young-il Kim ,  Moon-chul Lee ,  Tae-sik Park

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： G01N27/3276 ,  G01N29/036

摘要： Provided are a bio-molecules detecting apparatus using electromagnetic induction and a detecting method using the same. An exemplary apparatus includes: a cantilever of which one end is fixed and the other end is set up to be movable; a first metal formed on a plane of the cantilever and receiving a signal; a bio chip formed in the first metal and having probe biomolecules for searching particular information on a sample to be analyzed; an electromagnetic inductor configured to form a magnetic field; a signal source for applying the signal to the first metal; and a detector for measuring signal values of the first metal before and after the biomolecule is coupled with the sample. The apparatus detects the bio-couple by converting a change in mechanical properties before and after the bio-coupling based on electromagnetic induction to detect a bio-couple.

摘要翻译： 提供了使用电磁感应的生物分子检测装置和使用其的检测方法。 一种示例性装置包括：其一端被固定并且另一端被设置为可移动的悬臂; 形成在悬臂的平面上并接收信号的第一金属; 在第一金属中形成的生物芯片，并具有用于搜索待分析样品的特定信息的探针生物分子; 构造成形成磁场的电磁感应器; 用于将信号施加到第一金属的信号源; 以及用于测量生物分子之前和之后第一金属的信号值与检测器结合的检测器。 该装置通过基于电磁感应转换生物耦合之前和之后的机械特性的变化来检测生物耦合，以检测生物耦合。